Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Possible lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0288 | 0.0133 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.6994 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0093 | 0.0019 | 0.1392 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.0009 | 0.068 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0288 | 0.0133 | 0.0133 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0288 | 0.0133 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0093 | 0.0019 | 0.0019 |
Echinococcus granulosus | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Echinococcus granulosus | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Onchocerca volvulus | 0.0288 | 0.0133 | 0.5 | |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Mycobacterium ulcerans | esterase/lipase | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0288 | 0.0133 | 0.0133 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0288 | 0.0133 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0288 | 0.0133 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0077 | 0.0009 | 0.0009 |
Leishmania major | ecotin, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0288 | 0.0133 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0288 | 0.0133 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0288 | 0.0133 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0077 | 0.0009 | 0.0009 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0288 | 0.0133 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0288 | 0.0133 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0093 | 0.0019 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | hypothetical protein | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Echinococcus multilocularis | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0093 | 0.0019 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0093 | 0.0019 | 0.001 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0288 | 0.0133 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0093 | 0.0019 | 0.1392 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0093 | 0.0019 | 0.0019 |
Echinococcus granulosus | carboxylesterase 5A | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.6994 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | lipase LipH | 0.0288 | 0.0133 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0288 | 0.0133 | 0.0125 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.0009 | 0.068 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0093 | 0.0019 | 0.0019 |
Mycobacterium ulcerans | esterase LipC | 0.0288 | 0.0133 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0093 | 0.0019 | 0.1392 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | Tested for the inhibition of umor necrosis factor alpha production after intravenous administration of the compound at the dosage of 30 mg/kg to rat | ChEMBL. | 11958991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.