Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0317 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0317 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0317 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0317 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.869 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0317 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.869 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0317 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0317 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.869 | 1 | 1 |
Brugia malayi | aryl-acylamidase | 0.0317 | 0 | 0.5 |
Onchocerca volvulus | 0.0317 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0317 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0317 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0317 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.869 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 1.869 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0317 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0317 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0317 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0317 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0317 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0317 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0317 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0317 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0317 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0317 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.048 | Compound was evaluated for the frequency of the binding site that is the number of molecules bound to every nucleotide (1/n) | ChEMBL. | 6540313 |
Activity (binding) | = 20.83 | Compound was evaluated for the binding parameter by determining the number of nucleotides occluded by a bound angelicin (n) | ChEMBL. | 6540313 |
ID50 (functional) | = 2.63e-17 quanta | Compound was evaluated for 50% inhibition of DNA synthesis in Ehrlisch ascites tumor cells by irradiation (365 nM) at 1.9 x 10e -5M incubated with [3H]-thymidine at 37 degree C (p 0.05) | ChEMBL. | 6540313 |
ID50 (functional) | = 2.63e-17 quanta | Compound was evaluated for 50% inhibition of DNA synthesis in Ehrlisch ascites tumor cells by irradiation (365 nM) at 1.9 x 10e -5M incubated with [3H]-thymidine at 37 degree C (p 0.05) | ChEMBL. | 6540313 |
K (binding) | = 925 | Compound was evaluated for the association constant to an isolated site of DNA | ChEMBL. | 6540313 |
Rate constant (binding) | = 0.036 min-1 | Compound was evaluated for the binding parameter by determining rate constant | ChEMBL. | 6540313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.