Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0254 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.4997 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0254 | 0 | 0.5 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Brugia malayi | aryl-acylamidase | 0.0254 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0254 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.4997 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 51 % | Compound was measured for percentage inhibition of aspirin-induced ulcers at 3 mg/kg after po administration | ChEMBL. | 7328596 |
Inhibition (functional) | = 89 % | Compound was measured for percentage inhibition of aspirin-induced ulcers at 10 mg/kg after po administration | ChEMBL. | 7328596 |
Inhibition (functional) | = 100 % | Compound was measured for percentage inhibition of aspirin-induced ulcers at 30 mg/kg after po administration | ChEMBL. | 7328596 |
Reduction (functional) | < 30 % | Antisecretory activity was evaluated in adult mongrel dog after po administration of the compound at 8 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | < 30 % | Compound was measured for percentage reduction in insulin hypoglycemia stimulated canine gastric acid secretion after po administration at 8 mg/kg dosage | ChEMBL. | 7328596 |
Reduction (functional) | < 30 % | Compound was measured for percentage reduction in food stimulated canine gastric acid secretion after po administration at 8 mg/kg dosage | ChEMBL. | 7328596 |
Reduction (functional) | = 58 % | Compound was measured for percentage reduction in dimaprit stimulated canine gastric acid secretion after iv administration at 5 mg/kg dosage | ChEMBL. | 7328596 |
Reduction (functional) | = 69 % | Compound was measured for percentage reduction in food stimulated canine gastric acid secretion after iv administration at 5 mg/kg dosage | ChEMBL. | 7328596 |
Reduction (functional) | = 70 % | Antisecretory activity was evaluated in adult mongrel dog after iv administration at 5 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 79 % | Compound was measured for percentage reduction in insulin hypoglycemia stimulated canine gastric acid secretion after iv administration at 5 mg/kg dosage | ChEMBL. | 7328596 |
Reduction (functional) | = 95 % | Antisecretory activity was evaluated in pylorus ligated rat after iv administration at 40 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.