Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0254 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0254 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.4997 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0254 | 0 | 0.5 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Brugia malayi | aryl-acylamidase | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.4997 | 1 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0254 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 74 % | Compound was measured for percentage inhibition of aspirin-induced ulcers at 30 mg/kg after po administration | ChEMBL. | 7328596 |
Reduction (functional) | < 30 % | Antisecretory activity was evaluated in adult mongrel dog after po administration of the compound at 8 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 35 % | Antisecretory activity was evaluated in adult mongrel dog after iv administration at 5 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 95 % | Antisecretory activity was evaluated in pylorus ligated rat after iv administration at 40 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.