Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0254 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.4997 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0254 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0254 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.4997 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0254 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Brugia malayi | aryl-acylamidase | 0.0254 | 0 | 0.5 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0254 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 31 % | Antisecretory activity was evaluated in adult mongrel dog after iv administration at 5 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 54 % | Antisecretory activity was evaluated in pylorus ligated rat after iv administration at 40 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.