Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ribonuclease H1, putative | 0.0275 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0307 | 0.028 | 0.028 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0307 | 0.028 | 0.028 |
Brugia malayi | RNase H family protein | 0.0275 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0432 | 0.1355 | 0.1355 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0307 | 0.028 | 0.028 |
Brugia malayi | RNase H family protein | 0.0275 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1101 | 0.7096 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0275 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1101 | 0.7096 | 0.7096 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0275 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0307 | 0.028 | 0.028 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0275 | 0 | 0.5 |
Toxoplasma gondii | ribonuclease HI protein | 0.0275 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0275 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1101 | 0.7096 | 0.7096 |
Trypanosoma brucei | RNA helicase, putative | 0.1439 | 1 | 1 |
Echinococcus granulosus | hormone sensitive lipase | 0.1101 | 0.7096 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0275 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0275 | 0 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0275 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1101 | 0.7096 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1101 | 0.7096 | 0.7096 |
Brugia malayi | RNase H family protein | 0.0275 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0307 | 0.028 | 0.028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 429 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR alpha receptor | ChEMBL. | 12617924 |
EC50 (functional) | = 429 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR alpha receptor | ChEMBL. | 12617924 |
EC50 (functional) | = 485 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR gamma receptor | ChEMBL. | 12617924 |
EC50 (functional) | = 485 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR gamma receptor | ChEMBL. | 12617924 |
Inhibition (functional) | = 74 % | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR delta at 3 microM; Max % | ChEMBL. | 12617924 |
Inhibition (functional) | = 74 % | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR delta at 3 microM; Max % | ChEMBL. | 12617924 |
Ki (binding) | = 7.6 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) | ChEMBL. | 12617924 |
Ki (binding) | = 7.6 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) | ChEMBL. | 12617924 |
Ki (binding) | = 8.9 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) | ChEMBL. | 12617924 |
Ki (binding) | = 8.9 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) | ChEMBL. | 12617924 |
Ki (binding) | = 37.5 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) | ChEMBL. | 12617924 |
Ki (binding) | = 37.5 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) | ChEMBL. | 12617924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.