Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.0086 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0077 | 0.0086 | 1 |
Brugia malayi | TAZ zinc finger family protein | 0.0109 | 0.0155 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4566 | 1 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0075 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Esterase, putative | 0.0077 | 0.0086 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4566 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0077 | 0.0086 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.0459 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0077 | 0.0086 | 0.1862 |
Mycobacterium ulcerans | lipase LipU | 0.0077 | 0.0086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0061 | 0.0061 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0077 | 0.0086 | 0.1862 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0077 | 0.0086 | 1 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0077 | 0.0086 | 0.1862 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | CBP-B | 0.0075 | 0.0081 | 0.0081 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0077 | 0.0086 | 0.1862 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0061 | 0.0061 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0077 | 0.0086 | 0.0086 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0077 | 0.0086 | 0.1862 |
Mycobacterium ulcerans | esterase LipW | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0077 | 0.0086 | 1 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0077 | 0.0086 | 0.1862 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0086 | 1 |
Loa Loa (eye worm) | ammd protein | 0.0077 | 0.0086 | 0.0086 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0077 | 0.0086 | 1 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0077 | 0.0086 | 0.1862 |
Brugia malayi | aryl-acylamidase | 0.0077 | 0.0086 | 0.5527 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0061 | 0.3915 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | esterase/lipase | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0077 | 0.0086 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.4566 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.0061 | 0.0061 |
Onchocerca volvulus | 0.0077 | 0.0086 | 1 | |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0077 | 0.0086 | 0.1862 |
Loa Loa (eye worm) | hypothetical protein | 0.4566 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0077 | 0.0086 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.0061 | 0.0061 |
Echinococcus granulosus | CREB binding protein | 0.0067 | 0.0063 | 0.0063 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0077 | 0.0086 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0077 | 0.0086 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0061 | 0.0061 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0109 | 0.0155 | 0.0155 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0077 | 0.0086 | 0.1862 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0077 | 0.0086 | 0.1862 |
Mycobacterium ulcerans | lipase LipH | 0.0077 | 0.0086 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | esterase LipC | 0.0077 | 0.0086 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0077 | 0.0086 | 0.0086 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.0061 | 0.0061 |
Trichomonas vaginalis | Esterase, putative | 0.0077 | 0.0086 | 1 |
Mycobacterium ulcerans | esterase LipO | 0.0077 | 0.0086 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0061 | 0.3915 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0061 | 0.0061 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0077 | 0.0086 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0077 | 0.0086 | 0.1862 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0027 | 0.0027 |
Mycobacterium leprae | Possible lipase LipU | 0.0077 | 0.0086 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0077 | 0.0086 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0109 | 0.0155 | 0.0155 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0109 | 0.0155 | 0.0155 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0077 | 0.0086 | 0.1862 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0077 | 0.0086 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 1400 uM | Concentration of compound required to reduce by 50% the number of herpes simplex virus (HSV-1) plaques in vero cells | ChEMBL. | 1548681 |
ED50 (functional) | > 1400 uM | Concentration of compound required to reduce by 50% the number of african swine fever virus (ASFV) plaques in vero cells | ChEMBL. | 1548681 |
ED50 (functional) | > 1400 uM | Concentration of compound required to reduce by 50% the number of polio virus plaques in vero cells | ChEMBL. | 1548681 |
ED50 (functional) | > 1400 uM | Concentration of compound required to reduce by 50% the number of coxsackie virus plaques in vero cells | ChEMBL. | 1548681 |
ED50 (functional) | > 1400 uM | Concentration of compound required to reduce by 50% the number of vesicular stomatitis virus (VSV) plaques in vero cells | ChEMBL. | 1548681 |
ED90 (functional) | > 200 uM | Effective dose of the compound which reduces the HIV-1 yield in C8166 cells by 90% | ChEMBL. | 1548681 |
ID50 (functional) | = 280 uM | Compound concentration required to reduce by 50% the number of T-C8166 lymphoblastoid cells after three cell cycles | ChEMBL. | 1548681 |
ID50 (functional) | = 540 uM | Compound concentration required to reduce by 50% the number of T-MT4 lymphoblastoid cells after three cell cycles | ChEMBL. | 1548681 |
ID50 (functional) | = 710 uM | Compound concentration required to reduce by 50% the number of T-H9 lymphoblastoid cells after three cell cycles | ChEMBL. | 1548681 |
ID50 (functional) | > 1400 uM | Compound concentration required to reduce by 50% the number of fibroblast-like cells (Vero) after three cell cycles | ChEMBL. | 1548681 |
ID50 (functional) | > 1400 uM | Compound concentration required to reduce by 50% the number of murine lymphocytic leukemia (L1210) cells after three cell cycles | ChEMBL. | 1548681 |
ID50 (functional) | = 1400 uM | Compound concentration required to reduce by 50% the number of human B (Raji)cells after three cell cycles | ChEMBL. | 1548681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.