Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin I converting enzyme | References | |
Homo sapiens | angiotensin I converting enzyme 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5413 | 1 | 0.5 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0945 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.5413 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.5413 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5413 | 1 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5413 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AI recovery time (functional) | = 5 min | Time required after administration of 30 mg/kg of compound po, for the AI response to return to 70% of the pretreatment control response | ChEMBL. | 6173481 |
AI recovery time (functional) | = 24 min | Time required after administration of 3 mg/kg of compound iv, for the AI response to return to 70% of the pretreatment control response | ChEMBL. | 6173481 |
Change (functional) | = -5 mmHg | Change in mean aortic blood pressure in the conscious renal hypertensive rat after oral administration of 30 mg/kg | ChEMBL. | 6173481 |
IC50 (binding) | = 0.0000000014 M | Concentration of the compound required to inhibit the activity of Angiotensin I converting enzyme by 50% | ChEMBL. | 6173481 |
IC50 (binding) | = 0.0000000014 M | Concentration of the compound required to inhibit the activity of Angiotensin I converting enzyme by 50% | ChEMBL. | 6173481 |
Max effect (functional) | = 174 mmHg | Maximum effect of 30 mg/kg administered orally on mean aortic blood pressure in the conscious renal hypertensive rat | ChEMBL. | 6173481 |
Max inhibition (functional) | = 33 % | Maxmimum inhibition of the angiotensin I challenge at 30mg/kg, po in conscious, normotensive rats | ChEMBL. | 6173481 |
Max inhibition (functional) | = 74 % | Maxmimum inhibition of the angiotensin I challenge at 3mg/kg, iv, in conscious, normotensive rats | ChEMBL. | 6173481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.