Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipase LipU | 0.0204 | 0.0066 | 0.5 |
Onchocerca volvulus | 0.0204 | 0.0066 | 0.5 | |
Mycobacterium leprae | Possible lipase LipU | 0.0204 | 0.0066 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.2041 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0204 | 0.0066 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0204 | 0.0066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.2041 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0204 | 0.0066 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.2041 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0204 | 0.0066 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0204 | 0.0066 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0204 | 0.0066 | 0.5 |
Leishmania major | ecotin, putative | 0.0204 | 0.0066 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0204 | 0.0066 | 1 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0204 | 0.0066 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.0066 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0204 | 0.0066 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0204 | 0.0066 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0204 | 0.0066 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0204 | 0.0066 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.2041 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0204 | 0.0066 | 0.0066 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0204 | 0.0066 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.2041 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0204 | 0.0066 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0204 | 0.0066 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0204 | 0.0066 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0204 | 0.0066 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0204 | 0.0066 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.7 uM | Inhibitory concentration against HIV-1 integrase by strand transfer method | ChEMBL. | 9083480 |
IC50 (binding) | = 2.7 uM | Inhibitory concentration against HIV-1 integrase by strand transfer method | ChEMBL. | 9083480 |
IC50 (binding) | = 3.4 uM | Inhibitory concentration to inhibit HIV-1 integrase by 3' -processing method | ChEMBL. | 9083480 |
IC50 (binding) | = 3.4 uM | Inhibitory concentration to inhibit HIV-1 integrase by 3' -processing method | ChEMBL. | 9083480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.