Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ammd protein | 0.0288 | 0.0133 | 0.0133 |
Mycobacterium ulcerans | esterase/lipase | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0288 | 0.0133 | 0.5 |
Onchocerca volvulus | 0.0288 | 0.0133 | 0.5 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0077 | 0.0009 | 0.0009 |
Leishmania major | ecotin, putative | 0.0288 | 0.0133 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0288 | 0.0133 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0288 | 0.0133 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0288 | 0.0133 | 0.0133 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 1.6994 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0093 | 0.0019 | 0.1392 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.0009 | 0.068 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0288 | 0.0133 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0093 | 0.0019 | 0.0019 |
Echinococcus granulosus | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Echinococcus granulosus | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | esterase LipO | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0288 | 0.0133 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0288 | 0.0133 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0077 | 0.0009 | 0.0009 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0093 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0288 | 0.0133 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0093 | 0.0019 | 0.1392 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | esterase LipC | 0.0288 | 0.0133 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0093 | 0.0019 | 0.0019 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0288 | 0.0133 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0093 | 0.0019 | 0.1392 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.0009 | 0.068 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.6994 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | lipase LipH | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0077 | 0.0009 | 0.0009 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0288 | 0.0133 | 0.0125 |
Mycobacterium ulcerans | lipase LipU | 0.0288 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0288 | 0.0133 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.6994 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0288 | 0.0133 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0288 | 0.0133 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0288 | 0.0133 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0288 | 0.0133 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0093 | 0.0019 | 0.1392 |
Echinococcus multilocularis | acetylcholinesterase | 0.0077 | 0.0009 | 0.0009 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0093 | 0.0019 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0093 | 0.0019 | 0.001 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0093 | 0.0019 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | hypothetical protein | 0.0288 | 0.0133 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0077 | 0.0009 | 0.0009 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0288 | 0.0133 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0288 | 0.0133 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0288 | 0.0133 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0288 | 0.0133 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 23 % | Tested for the inhibition of umor necrosis factor alpha production after intravenous administration of the compound at the dosage of 30 mg/kg to rat | ChEMBL. | 11958991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.