TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 286.364 | Formula: C15H26O5
H donors: 1 H acceptors: 1 LogP: 2.14 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCC[C@@H]1CCC[C@H]2C31OO[C@](O[C@@H]3OC)(C(C2)C)C
InChi: 1S/C15H26O5/c1-10-9-12-6-4-5-11(7-8-16)15(12)13(17-3)18-14(10,2)19-20-15/h10-13,16H,4-9H2,1-3H3/t10?,11-,12+,13-,14-,15?/m0/s1
InChiKey: BZBGKPOOTLXLKR-VAPJPJOESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0323186	0.0305705	0.0305705
Schistosoma mansoni	alpha-glucosidase	0.567722	0.900257	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0152452	0.00283712	0.00283712
Brugia malayi	hypothetical protein	0.0152452	0.00283712	0.00283712
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0964952	0.134816	0.13454
Echinococcus multilocularis	ceramide glucosyltransferase	0.23883	0.366019	0.365816
Schistosoma mansoni	bile acid beta-glucosidase-related	0.14914	0.22033	0.244741
Loa Loa (eye worm)	hypothetical protein	0.0254168	0.0193595	0.0193595
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0152452	0.00283712	0.00251833
Schistosoma mansoni	alpha-l-fucosidase	0.0998308	0.140234	0.155771
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0323186	0.0305705	0.0339575
Brugia malayi	nuclear receptor NHR-88	0.0152452	0.00283712	0.00283712
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0152452	0.00283712	0.00251833
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0323186	0.0305705	0.0302605
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.15133	0.223887	0.537069
Brugia malayi	tailless protein	0.0152452	0.00283712	0.00283712
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0323186	0.0305705	0.0339575
Trichomonas vaginalis	alpha-glucosidase, putative	0.15133	0.223887	0.537069
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0152452	0.00283712	0.00283712
Brugia malayi	nuclear receptor RXR	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	hypothetical protein	0.100575	0.141444	0.141444
Trichomonas vaginalis	beta-galactosidase, putative	0.0556428	0.0684573	0.164218
Trichomonas vaginalis	alpha-glucosidase, putative	0.0664275	0.0859754	0.206241
Trichomonas vaginalis	alpha-glucosidase, putative	0.15133	0.223887	0.537069
Schistosoma mansoni	RAR-like nuclear receptor	0.0323186	0.0305705	0.0339575
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.208509	0.316767	0.316549
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.127832	0.185718	0.804914
Brugia malayi	ecdysone receptor	0.0152452	0.00283712	0.00283712
Echinococcus multilocularis	nuclear receptor nhr 48	0.0152452	0.00283712	0.00251833
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.274155	0.423399	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0664275	0.0859754	0.265074
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0152452	0.00283712	0.00251833
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0323186	0.0305705	0.0477612
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0136953	0.000319596	0.000355006
Echinococcus multilocularis	adam 17 protease	0.0313592	0.029012	0.0287015
Loa Loa (eye worm)	beta-glucuronidase	0.0221626	0.0140735	0.0140735
Brugia malayi	Matrixin family protein	0.0208685	0.0119715	0.0119715
Schistosoma mansoni	nuclear receptor nhr-48	0.0152452	0.00283712	0.00315146
Loa Loa (eye worm)	ceramide glucosyltransferase	0.23883	0.366019	0.366019
Echinococcus granulosus	ceramide glucosyltransferase	0.23883	0.366019	0.365816
Brugia malayi	Alpha-L-fucosidase family protein	0.0998308	0.140234	0.140234
Leishmania major	polypeptide deformylase-like protein, putative	0.104612	0.148	0.595603
Loa Loa (eye worm)	hypothetical protein	0.0208685	0.0119715	0.0119715
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0323186	0.0305705	0.0339575
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Entamoeba histolytica	beta-galactosidase, putative	0.0334802	0.0324573	0.021578
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0964952	0.134816	0.525345
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0323186	0.0305705	0.0305705
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0323186	0.0305705	0.0302605
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0323186	0.0305705	0.0339575
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0401168	0.0432376	0.10372
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0152452	0.00283712	0.00251833
Echinococcus granulosus	glycogen debranching enzyme	0.0308811	0.0282355	0.0279248
Brugia malayi	Nuclear hormone receptor E75	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	conserved hypothetical protein	0.0158143	0.00376149	0.00902323
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0664275	0.0859754	0.206241
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0323186	0.0305705	0.0302605
Trichomonas vaginalis	glucosylceramidase, putative	0.196973	0.298028	0.714921
Brugia malayi	Nuclear hormone receptor-like 1	0.0323186	0.0305705	0.0305705
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.075875	0.101322	0.101034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0323186	0.0305705	0.0305705
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0323186	0.0305705	0.0302605
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0152452	0.00283712	0.00315146
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0323186	0.0305705	0.0305705
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0170734	0.00580684	0.005489
Brugia malayi	hypothetical protein	0.0170734	0.00580684	0.00580684
Loa Loa (eye worm)	hypothetical protein	0.0170734	0.00580684	0.00580684
Schistosoma mansoni	alpha-glucosidase	0.567722	0.900257	1
Loa Loa (eye worm)	hypothetical protein	0.0664275	0.0859754	0.0859754
Brugia malayi	nuclear hormone receptor	0.0152452	0.00283712	0.00283712
Trypanosoma cruzi	Peptide deformylase 2, putative	0.104612	0.148	0.595603
Schistosoma mansoni	pyruvate dehydrogenase	0.0913046	0.126385	0.140387
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0664275	0.0859754	0.206241
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0254168	0.0193595	0.0193595
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0462853	0.0532574	0.0868317
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0214758	0.0129579	0.0126423
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0664275	0.0859754	0.295116
Trypanosoma brucei	glucosidase, putative	0.15133	0.223887	1
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Schistosoma mansoni	hypothetical protein	0.0295897	0.0261378	0.0290336
Onchocerca volvulus	Bile acid receptor homolog	0.0466167	0.0537957	0.0877587
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Brugia malayi	Matrixin family protein	0.0208685	0.0119715	0.0119715
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Brugia malayi	manba-prov protein	0.0221626	0.0140735	0.0140735
Loa Loa (eye worm)	hypothetical protein	0.0964952	0.134816	0.134816
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0152452	0.00283712	0.00251833
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.104612	0.148	0.595603
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.017263	0.0061147	0.00679217
Plasmodium vivax	peptide deformylase, putative	0.274155	0.423399	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0323186	0.0305705	0.0305705
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0323186	0.0305705	0.0339575
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.138966	0.203803	0.203803
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.075875	0.101322	0.101034
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.270134	0.416868	0.416868
Brugia malayi	Ceramide glucosyltransferase	0.23883	0.366019	0.366019
Schistosoma mansoni	nuclear receptor	0.0152452	0.00283712	0.00315146
Echinococcus granulosus	neutral alpha glucosidase AB	0.15133	0.223887	0.223639
Trichomonas vaginalis	maltase-glucoamylase, putative	0.15133	0.223887	0.537069
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0664275	0.0859754	0.206241
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.274155	0.423399	1
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Trichomonas vaginalis	alpha-glucosidase, putative	0.0664275	0.0859754	0.206241
Onchocerca volvulus		0.37272	0.583504	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0323186	0.0305705	0.0302605
Loa Loa (eye worm)	matrix metalloproteinase	0.0208685	0.0119715	0.0119715
Trichomonas vaginalis	alpha-glucosidase, putative	0.15133	0.223887	0.537069
Schistosoma mansoni	hypothetical protein	0.07424	0.0986657	0.109597
Loa Loa (eye worm)	nuclear hormone receptor	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	conserved hypothetical protein	0.0556428	0.0684573	0.164218
Echinococcus multilocularis	bile acid beta glucosidase	0.14914	0.22033	0.22008
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0280931	0.0237068	0.0233947
Brugia malayi	conserved hypotetical protein	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0170734	0.00580684	0.00580684
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0152452	0.00283712	0.00251833
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Plasmodium falciparum	peptide deformylase	0.274155	0.423399	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	matrixin family protein	0.0504582	0.0600357	0.0600357
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0323186	0.0305705	0.0339575
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0323186	0.0305705	0.0305705
Trichomonas vaginalis	alpha-glucosidase, putative	0.0664275	0.0859754	0.206241
Loa Loa (eye worm)	alpha-L-fucosidase	0.0998308	0.140234	0.140234
Schistosoma mansoni	bile acid beta-glucosidase-related	0.14914	0.22033	0.244741
Schistosoma mansoni	pyruvate dehydrogenase	0.0913046	0.126385	0.140387
Schistosoma mansoni	hypothetical protein	0.0402301	0.0434215	0.0482324
Loa Loa (eye worm)	hypothetical protein	0.0208685	0.0119715	0.0119715
Loa Loa (eye worm)	steroid hormone receptor	0.22713	0.347014	0.347014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0323186	0.0305705	0.0305705
Onchocerca volvulus		0.0323186	0.0305705	0.0477612
Trichomonas vaginalis	alpha-glucosidase, putative	0.15133	0.223887	0.537069
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0280931	0.0237068	0.0233947
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0664275	0.0859754	0.265074
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0409954	0.0446647	0.052435
Brugia malayi	metalloprotease disintegrin 16 with thrombospondin type I motif	0.0136953	0.000319596	0.000319596
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Onchocerca volvulus		0.147193	0.217167	0.36911
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0664275	0.0859754	0.0859754
Trichomonas vaginalis	beta-mannosidase, putative	0.0158205	0.00377164	0.00904756
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0323186	0.0305705	0.0305705
Brugia malayi	kinase, mitochondrial precursor	0.0964952	0.134816	0.134816
Brugia malayi	nuclear receptor NHR-88	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	hypothetical protein	0.0170734	0.00580684	0.00580684
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0323186	0.0305705	0.0305705
Trichomonas vaginalis	sucrase-isomaltase, putative	0.127832	0.185718	0.445508
Echinococcus granulosus	bile acid beta glucosidase	0.14914	0.22033	0.22008
Brugia malayi	Matrixin family protein	0.0208685	0.0119715	0.0119715
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0176597	0.00675913	0.00675913
Schistosoma mansoni	hypothetical protein	0.0223061	0.0143066	0.0158917
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	hypothetical protein	0.0466167	0.0537957	0.0537957
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0323186	0.0305705	0.0302605
Toxoplasma gondii	hypothetical protein	0.274155	0.423399	1
Echinococcus multilocularis	glycogen debranching enzyme	0.0308811	0.0282355	0.0279248
Brugia malayi	Pre-SET motif family protein	0.138966	0.203803	0.203803
Schistosoma mansoni	thyroid hormone receptor	0.0323186	0.0305705	0.0339575
Trypanosoma cruzi	hypothetical protein, conserved	0.15133	0.223887	1
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0176597	0.00675913	0.00675913
Loa Loa (eye worm)	hypothetical protein	0.0308811	0.0282355	0.0282355
Brugia malayi	orphan nuclear receptor NR2E1	0.0152452	0.00283712	0.00283712
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.14914	0.22033	0.22008
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0964952	0.134816	0.525345
Onchocerca volvulus		0.0208685	0.0119715	0.0157307
Mycobacterium ulcerans	peptide deformylase	0.274155	0.423399	1
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.23883	0.366019	0.625456
Trichomonas vaginalis	set domain proteins, putative	0.147193	0.217167	0.520949
Brugia malayi	Nuclear hormone receptor-like 1	0.0170734	0.00580684	0.00580684
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0964952	0.134816	0.525345
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0170734	0.00580684	0.0064502
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Echinococcus granulosus	thyroid hormone receptor alpha	0.210056	0.31928	0.319063
Onchocerca volvulus	Glucosylceramidase homolog	0.156217	0.231826	0.394354
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0323186	0.0305705	0.0302605
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0323186	0.0305705	0.0302605
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0323186	0.0305705	0.0302605
Echinococcus granulosus	nuclear receptor nhr 48	0.0152452	0.00283712	0.00251833
Brugia malayi	Glycosyl hydrolases family 31 protein	0.629127	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.15133	0.223887	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0323186	0.0305705	0.0305705
Schistosoma mansoni	zinc finger protein	0.0152452	0.00283712	0.00315146
Brugia malayi	nuclear hormone receptor family member odr-7	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0308811	0.0282355	0.0677325
Loa Loa (eye worm)	DR-78	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	hypothetical protein	0.0170734	0.00580684	0.00580684
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0308811	0.0282355	0.0677325
Echinococcus granulosus	non lysosomal glucosylceramidase	0.14914	0.22033	0.22008
Mycobacterium ulcerans	alpha-L-fucosidase	0.208509	0.316767	0.736085
Echinococcus multilocularis	ecdysone induced protein 78C	0.0323186	0.0305705	0.0302605
Schistosoma mansoni	nuclear hormone receptor	0.0323186	0.0305705	0.0339575
Echinococcus multilocularis	lysosomal alpha glucosidase	0.629127	1	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0152452	0.00283712	0.00315146
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0280931	0.0237068	0.0263334
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0358048	0.0362332	0.0313402
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0152452	0.00283712	0.00251833
Onchocerca volvulus		0.0295897	0.0261378	0.0401274
Trichomonas vaginalis	glucosylceramidase, putative	0.196973	0.298028	0.714921
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Schistosoma mansoni	ceramide glucosyltransferase	0.23883	0.366019	0.406571
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.270134	0.416868	0.416868
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0323186	0.0305705	0.0305705
Leishmania major	alpha glucosidase II subunit, putative	0.15133	0.223887	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.15133	0.223887	0.223887
Giardia lamblia	Ceramide glucosyltransferase	0.108677	0.154604	1
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.104612	0.148	0.595603
Brugia malayi	ecdysteroid receptor	0.0466167	0.0537957	0.0537957
Trypanosoma cruzi	Peptide deformylase 2, putative	0.104612	0.148	0.595603
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0323186	0.0305705	0.0305705
Brugia malayi	Matrixin family protein	0.0208685	0.0119715	0.0119715
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.0308811	0.0282355	0.0113305
Schistosoma mansoni	ceramide glucosyltransferase	0.23883	0.366019	0.406571
Brugia malayi	photoreceptor-specific nuclear receptor	0.0323186	0.0305705	0.0305705
Schistosoma mansoni	thyroid hormone receptor	0.0323186	0.0305705	0.0339575
Treponema pallidum	polypeptide deformylase (def)	0.274155	0.423399	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0323186	0.0305705	0.0305705
Echinococcus granulosus	lysosomal alpha glucosidase	0.629127	1	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.15133	0.223887	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0150669	0.00254751	0.00254751
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0964952	0.134816	0.13454
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0208685	0.0119715	0.0132978
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0323186	0.0305705	0.0305705
Trypanosoma brucei	Polypeptide deformylase 1	0.104612	0.148	0.595603
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0323186	0.0305705	0.0305705
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.15133	0.223887	0.223887
Echinococcus multilocularis	lysosomal alpha glucosidase	0.629127	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0323186	0.0305705	0.0302605
Schistosoma mansoni	nuclear receptor	0.0152452	0.00283712	0.00315146
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0152452	0.00283712	0.00251833
Brugia malayi	Hemopexin family protein	0.0295897	0.0261378	0.0261378
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.629127	1	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0964952	0.134816	0.149753
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0323186	0.0305705	0.0302605
Schistosoma mansoni	alpha glucosidase	0.15133	0.223887	0.248692
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Brugia malayi	Steroid receptor seven-up type 2	0.0323186	0.0305705	0.0305705
Echinococcus multilocularis	neutral alpha glucosidase AB	0.15133	0.223887	0.223639
Brugia malayi	Nuclear hormone receptor-like 1	0.0170734	0.00580684	0.00580684
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0664275	0.0859754	0.206241
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0280931	0.0237068	0.0263334
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0323186	0.0305705	0.0302605
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	alpha-glucosidase, putative	0.0664275	0.0859754	0.206241
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0401168	0.0432376	0.10372
Loa Loa (eye worm)	hypothetical protein	0.0323186	0.0305705	0.0305705
Echinococcus granulosus	adam 17 protease	0.0351711	0.0352039	0.0348955
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0170734	0.00580684	0.0064502
Loa Loa (eye worm)	matrixin family protein	0.0462853	0.0532574	0.0532574
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0664275	0.0859754	0.143177
Brugia malayi	hypothetical protein	0.0170734	0.00580684	0.00580684
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.15133	0.223887	0.537069
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0664275	0.0859754	0.265074
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0280931	0.0237068	0.0263334
Trichomonas vaginalis	alpha-glucosidase, putative	0.15133	0.223887	0.537069
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0323186	0.0305705	0.0339575
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0308811	0.0282355	0.0282355
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0280931	0.0237068	0.0263334
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.15133	0.223887	0.500836
Schistosoma mansoni	beta-mannosidase	0.0158205	0.00377164	0.00418951
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0323186	0.0305705	0.0302605
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.208509	0.316767	0.316549
Echinococcus multilocularis	FTZ F1 alpha	0.0323186	0.0305705	0.0302605
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0280931	0.0237068	0.0233947
Trichomonas vaginalis	glycoside hydrolase, putative	0.112223	0.160364	0.384687
Loa Loa (eye worm)	hypothetical protein	0.0170734	0.00580684	0.00580684
Brugia malayi	Nuclear hormone receptor E75	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Leishmania major	glycosyl hydrolase-like protein	0.0664275	0.0859754	0.265074
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Trichomonas vaginalis	glucosylceramidase, putative	0.156217	0.231826	0.556113
Schistosoma mansoni	retinoic acid receptor RXR	0.0323186	0.0305705	0.0339575
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0323186	0.0305705	0.0305705
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Schistosoma mansoni	coup transcription factor	0.0323186	0.0305705	0.0339575
Loa Loa (eye worm)	hypothetical protein	0.0169055	0.00553402	0.00553402
Trichomonas vaginalis	glucosylceramidase, putative	0.270134	0.416868	1
Brugia malayi	Beta-glucuronidase precursor	0.0221626	0.0140735	0.0140735
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0964952	0.134816	0.13454
Schistosoma mansoni	ADAM17 peptidase (M12 family)	0.0313592	0.029012	0.0322263
Loa Loa (eye worm)	hypothetical protein	0.0170734	0.00580684	0.00580684
Brugia malayi	steroid hormone receptor	0.22713	0.347014	0.347014
Schistosoma mansoni	nuclear hormone receptor	0.0152452	0.00283712	0.00315146
Echinococcus granulosus	FTZ F1 alpha	0.0323186	0.0305705	0.0302605
Brugia malayi	nuclear receptor NHR-67	0.0152452	0.00283712	0.00283712
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.274155	0.423399	0.5
Onchocerca volvulus	Matrilysin homolog	0.0208685	0.0119715	0.0157307
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0323186	0.0305705	0.0302605
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0323186	0.0305705	0.0305705
Onchocerca volvulus	Protein ultraspiracle homolog	0.0323186	0.0305705	0.0477612
Chlamydia trachomatis	peptide deformylase	0.274155	0.423399	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0152452	0.00283712	0.00283712
Loa Loa (eye worm)	hypothetical protein	0.0208685	0.0119715	0.0119715
Onchocerca volvulus	Matrilysin homolog	0.0462853	0.0532574	0.0868317
Brugia malayi	hypothetical protein	0.0152452	0.00283712	0.00283712
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0152452	0.00283712	0.00251833
Brugia malayi	Matrixin family protein	0.0504582	0.0600357	0.0600357
Brugia malayi	nuclear receptor RXR	0.0170734	0.00580684	0.00580684
Brugia malayi	nuclear hormone receptor	0.0323186	0.0305705	0.0305705
Trypanosoma brucei	Peptide deformylase 2	0.104612	0.148	0.595603
Loa Loa (eye worm)	hypothetical protein	0.090091	0.124413	0.124413
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0214758	0.0129579	0.0126423
Echinococcus granulosus	ecdysone induced protein 78C	0.0323186	0.0305705	0.0302605
Loa Loa (eye worm)	hypothetical protein	0.0152452	0.00283712	0.00283712
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0170734	0.00580684	0.005489
Schistosoma mansoni	nuclear hormone receptor	0.0152452	0.00283712	0.00315146

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 7.7 nM	in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes .	ChEMBL.	9526569
IC50 (functional)	= 7.7 nM	in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes .	ChEMBL.	9526569
IC50 (functional)	= 1300 nM	in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes	ChEMBL.	9526569
IC50 (functional)	= 1300 nM	in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes	ChEMBL.	9526569

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	9526569

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL366403

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 305221