Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel | Starlite/ChEMBL | References |
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1D subunit | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -5.36 | Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | ChEMBL. | 9016337 |
IC50 (binding) | = 4350 nM | Inhibition of [3H]-nitrendipine binding at L-type [Ca2+] channel in rat cortex homogenate by 50%. | ChEMBL. | 7473567 |
IC50 (binding) | = 4350 nM | Inhibition of [3H]-nitrendipine binding at L-type [Ca2+] channel in rat cortex homogenate by 50%. | ChEMBL. | 7473567 |
Ki (functional) | = 1630 nM | Calcium antagonistic activity by measuring [3H]-nitrendipine displacement at L-type [Ca2+] channel in rat cortex homogenate | ChEMBL. | 7473567 |
Ki (functional) | = 1630 nM | Calcium antagonistic activity by measuring [3H]-nitrendipine displacement at L-type [Ca2+] channel in rat cortex homogenate | ChEMBL. | 7473567 |
Log IC50 (binding) | = 5.36 | Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | ChEMBL. | 9016337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.