Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.002 | 0.0917 | 0.0917 |
Schistosoma mansoni | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0025 | 0.186 | 0.1038 |
Echinococcus multilocularis | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0023 | 0.1307 | 0.043 |
Trichomonas vaginalis | deoxyhypusine synthase, putative | 0.0068 | 1 | 1 |
Giardia lamblia | Deoxyhypusine synthase, putative | 0.0068 | 1 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.002 | 0.0917 | 0.0917 |
Schistosoma mansoni | amine oxidase | 0.002 | 0.0917 | 0.0917 |
Trypanosoma cruzi | deoxyhypusine synthase, putative | 0.0026 | 0.1911 | 0.1095 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0025 | 0.186 | 0.186 |
Leishmania major | p450 reductase, putative | 0.0025 | 0.186 | 0.1038 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.002 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.002 | 0.0917 | 0.0917 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.002 | 0.0917 | 0.0917 |
Leishmania major | deoxyhypusine synthase, putative | 0.0068 | 1 | 1 |
Trypanosoma cruzi | deoxyhypusine synthase, putative | 0.0026 | 0.1911 | 0.1095 |
Leishmania major | deoxyhypusine synthase;with=GeneDB:Linj34_V3.0350 | 0.0026 | 0.1911 | 0.1095 |
Trypanosoma brucei | deoxyhypusine synthase | 0.0026 | 0.1911 | 0.0063 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0025 | 0.186 | 0.186 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.002 | 0.0917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Schistosoma mansoni | amine oxidase | 0.002 | 0.0917 | 0.0917 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0025 | 0.186 | 0.186 |
Trypanosoma cruzi | p450 reductase, putative | 0.0025 | 0.186 | 0.1038 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0025 | 0.186 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.002 | 0.0917 | 0.0917 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0025 | 0.186 | 0.1038 |
Brugia malayi | flavodoxin family protein | 0.0025 | 0.186 | 0.186 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0917 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.186 | 0.186 |
Onchocerca volvulus | 0.002 | 0.0917 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0025 | 0.186 | 0.1038 |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0023 | 0.1307 | 0.043 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.002 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Toxoplasma gondii | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0025 | 0.186 | 0.1038 |
Plasmodium vivax | deoxyhypusine synthase, putative | 0.0068 | 1 | 1 |
Echinococcus multilocularis | 0.002 | 0.0917 | 0.0917 | |
Plasmodium falciparum | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0025 | 0.186 | 0.1038 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.002 | 0.0917 | 0.5 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0025 | 0.186 | 0.186 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.002 | 0.0917 | 0.0917 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0025 | 0.186 | 0.1038 |
Trypanosoma brucei | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0025 | 0.186 | 0.0636 |
Brugia malayi | FAD binding domain containing protein | 0.0025 | 0.186 | 0.186 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0025 | 0.186 | 0.186 |
Echinococcus granulosus | deoxyhypusine synthase | 0.0068 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0917 | 0.0917 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.002 | 0.0917 | 0.5 |
Trypanosoma cruzi | deoxyhypusine synthase, putative | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0025 | 0.186 | 0.186 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.002 mg kg-1 | Ability to block the effect of exogenously administered PAF upon intravenous administration in PAF-induced rat skin permeability assay | ChEMBL. | 9438024 |
ED50 (functional) | = 0.002 mg kg-1 | Ability to block the effect of exogenously administered PAF upon intravenous administration in PAF-induced rat skin permeability assay | ChEMBL. | 9438024 |
ED50 (functional) | = 0.64 mg kg-1 | Tested in vivo for to block the effect of exogenously administered PAF upon oral administration in PAF-induced rat skin permeability assay | ChEMBL. | 9438024 |
ED50 (functional) | = 0.64 mg kg-1 | Tested in vivo for to block the effect of exogenously administered PAF upon oral administration in PAF-induced rat skin permeability assay | ChEMBL. | 9438024 |
Ki (binding) | = 0.15 nM | Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes | ChEMBL. | 9438024 |
Ki (binding) | = 0.15 nM | Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes | ChEMBL. | 9438024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.