Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0792 | 0.5421 | 1 |
Brugia malayi | haloacid dehalogenase-like hydrolase family protein | 0.0446 | 0.1929 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.0792 | 0.5421 | 0.5421 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0793 | 0.5434 | 1 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.1245 | 1 | 1 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0661 | 0.4099 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.1245 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.1245 | 1 | 1 |
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0383 | 0.1289 | 0.1752 |
Loa Loa (eye worm) | sodium potassium adenosine triphosphatase | 0.0347 | 0.0931 | 0.0931 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0816 | 0.567 | 1 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0503 | 0.2501 | 0.2501 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0793 | 0.5434 | 0.2559 |
Trypanosoma brucei | P-type H+-ATPase, putative | 0.0503 | 0.2501 | 0.2934 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0561 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0931 | 0.0931 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0792 | 0.5421 | 0.2538 |
Echinococcus granulosus | nervana 2 | 0.1245 | 1 | 1 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0815 | 0.5656 | 1 |
Loa Loa (eye worm) | calcium ATPase | 0.0446 | 0.1929 | 0.1929 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0792 | 0.5421 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0638 | 0.3864 | 0.4645 |
Onchocerca volvulus | 0.1245 | 1 | 1 | |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1245 | 1 | 1 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0638 | 0.3864 | 0.6232 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0793 | 0.5434 | 0.921 |
Entamoeba histolytica | plasma membrane calcium-transporting ATPase 1, putative | 0.0445 | 0.1915 | 0.2163 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.1289 | 0.1289 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.997 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.997 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0793 | 0.5434 | 1 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0638 | 0.3864 | 0.6232 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1245 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1245 | 1 | 1 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0793 | 0.5434 | 1 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0792 | 0.5421 | 0.9954 |
Schistosoma mansoni | ATPase | 0.0792 | 0.5421 | 0.2538 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1245 | 1 | 1 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0503 | 0.2501 | 0.4248 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0347 | 0.0931 | 0.1155 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0638 | 0.3864 | 0.66 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0638 | 0.3864 | 0.66 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0792 | 0.5421 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1245 | 1 | 1 |
Brugia malayi | E1-E2 ATPase family protein | 0.0504 | 0.2515 | 0.406 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.1245 | 1 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0638 | 0.3864 | 0.6932 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.1245 | 1 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0661 | 0.4099 | 0.0383 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0347 | 0.0931 | 0.1155 |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0537 | 0.2846 | 0.5 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Leishmania major | calcium-translocating P-type ATPase | 0.0792 | 0.5421 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0792 | 0.5421 | 1 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0816 | 0.567 | 0.2943 |
Schistosoma mansoni | transmemberane protein | 0.1245 | 1 | 1 |
Trypanosoma cruzi | plasma-membrane proton-efflux P-type ATPase, putative | 0.0347 | 0.0931 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.058 | 0.058 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0561 | 0.3094 | 0.5152 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0503 | 0.2501 | 0.4248 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0792 | 0.5421 | 0.997 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0792 | 0.5421 | 0.2538 |
Leishmania major | calcium-transporting ATPase, putative | 0.0638 | 0.3864 | 0.4666 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0638 | 0.3864 | 0.4666 |
Echinococcus granulosus | nervana 2 | 0.1245 | 1 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0793 | 0.5434 | 1 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0638 | 0.3864 | 0.6932 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0661 | 0.4099 | 0.1583 |
Schistosoma mansoni | ATPase | 0.0792 | 0.5421 | 0.2538 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1245 | 1 | 1 |
Toxoplasma gondii | P-type ATPase PMA1 | 0.0503 | 0.2501 | 0.3487 |
Loa Loa (eye worm) | calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0383 | 0.1289 | 0.1289 |
Echinococcus multilocularis | nervana 2 | 0.1245 | 1 | 1 |
Leishmania major | P-type ATPase, putative | 0.0638 | 0.3864 | 0.4666 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0816 | 0.567 | 0.567 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0792 | 0.5421 | 1 |
Onchocerca volvulus | 0.1245 | 1 | 1 | |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Echinococcus multilocularis | nervana 2 | 0.1245 | 1 | 1 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0638 | 0.3864 | 0.6513 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.056 | 0.3081 | 0.5 |
Trypanosoma brucei | P-type H+-ATPase, putative | 0.0503 | 0.2501 | 0.2934 |
Echinococcus multilocularis | nervana 2 | 0.1245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 0.567 | 0.567 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0793 | 0.5434 | 0.2559 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0792 | 0.5421 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.1245 | 1 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.997 |
Trypanosoma cruzi | calcium-transporting ATPase, putative | 0.0383 | 0.1289 | 0.186 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0792 | 0.5421 | 0.9954 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0792 | 0.5421 | 1 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.1245 | 1 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.1245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.0161 | 0.0161 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha-3 chain, putative | 0.0347 | 0.0931 | 0.1078 |
Echinococcus granulosus | nervana 2 | 0.1245 | 1 | 1 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0793 | 0.5434 | 0.2559 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0661 | 0.4099 | 0.0383 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0792 | 0.5421 | 1 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0446 | 0.1929 | 0.2192 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0792 | 0.5421 | 1 |
Plasmodium vivax | P-type ATPase4, putative | 0.0793 | 0.5434 | 0.5 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0793 | 0.5434 | 0.2559 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0793 | 0.5434 | 1 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0793 | 0.5434 | 0.5 |
Brugia malayi | calcium ATPase | 0.0347 | 0.0931 | 0.1078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 40 % | Inhibition of tumour growth in 6C3HED lymphosarcoma inoculated mice following 150 mg/kg p.o. o.d. | ChEMBL. | No reference |
Ratio (ADMET) | = | Compound was evaluated for toxicity expressed as the ratio of number of deaths to the number of animals; 0/8 | ChEMBL. | No reference |
Ratio (ADMET) | = 0 | Compound was evaluated for toxicity expressed as the ratio of number of deaths to the number of animals; 0/8 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.