Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 alpha | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0654 | 1 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0116 | 0 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0654 | 1 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0116 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0437 | 0.5964 | 0.4101 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0645 | 0.9834 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0116 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Brugia malayi | intracellular kinase | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0645 | 0.9834 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0116 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0645 | 0.9834 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.0116 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 5 uM | Inhibition of rabbit GSK3 | ChEMBL. | 16279768 |
IC50 (binding) | = 5 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 5 uM | Inhibition of rabbit GSK3 | ChEMBL. | 16279768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.