Detailed information for compound 310633

Basic information

Technical information
  • TDR Targets ID: 310633
  • Name: methyl 3-tert-butyl-6,7-dichloro-4-oxido-1-ox oquinoxalin-1-ium-2-carboxylate
  • MW: 345.178 | Formula: C14H14Cl2N2O4
  • H donors: 0 H acceptors: 3 LogP: 2.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1[n+]([O-])c2cc(Cl)c(cc2[n+](c1C(C)(C)C)[O-])Cl
  • InChi: 1S/C14H14Cl2N2O4/c1-14(2,3)12-11(13(19)22-4)17(20)9-5-7(15)8(16)6-10(9)18(12)21/h5-6H,1-4H3
  • InChiKey: FZEQIOHXXIWEJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 3-tert-butyl-6,7-dichloro-4-oxido-1-oxo-quinoxalin-1-ium-2-carboxylate
  • 3-tert-butyl-6,7-dichloro-4-oxido-1-oxo-2-quinoxalin-1-iumcarboxylic acid methyl ester
  • methyl 3-tert-butyl-6,7-dichloro-4-oxidanidyl-1-oxo-quinoxalin-1-ium-2-carboxylate
  • 3-tert-butyl-6,7-dichloro-1-keto-4-oxido-quinoxalin-1-ium-2-carboxylic acid methyl ester
  • 2-Quinoxalinecarboxylic acid, 6,7-dichloro-3-(1,1-dimethylethyl)-, methyl ester, 1,4-dioxide
  • AIDS-220641
  • AIDS220641

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SH2 domain containing protein 0.0051 0.4451 0.4451
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0026 0.0823 0.1848
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0031 0.1576 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.009 1 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0046 0.3659 1
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0046 0.3659 1
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Echinococcus granulosus nervana 2 0.0069 0.6938 0.5991
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Onchocerca volvulus 0.004 0.2854 0.0334
Entamoeba histolytica SH2 domain containing protein 0.004 0.2854 0.6411
Loa Loa (eye worm) TK protein kinase 0.0051 0.4451 0.4451
Loa Loa (eye worm) hypothetical protein 0.0022 0.0279 0.0279
Echinococcus granulosus tyrosine protein kinase Btk29A 0.009 1 1
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0069 0.6938 0.5991
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0051 0.4451 0.2736
Loa Loa (eye worm) E1-E2 ATPase 0.0029 0.1297 0.1297
Echinococcus granulosus tensin C1 domain containing phosphatase 0.004 0.2854 0.0644
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0026 0.0823 0.0823
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.2854 0.0644
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0039 0.2713 0.6094
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.009 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0051 0.4451 0.2736
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Brugia malayi Protein kinase domain containing protein 0.0051 0.4451 0.4451
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.2854 0.2854
Schistosoma mansoni suppressor of cytokine signaling 0.004 0.2854 0.0644
Echinococcus granulosus nervana 2 0.0069 0.6938 0.5991
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0039 0.2713 0.0459
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0051 0.4451 0.2736
Trichomonas vaginalis cation-transporting ATPase, putative 0.0046 0.3659 1
Echinococcus granulosus expressed protein 0.0039 0.2713 0.0459
Schistosoma mansoni sorbin 0.0039 0.2713 0.0459
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.004 0.2854 0.0334
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 1 1
Echinococcus multilocularis nervana 2 0.0069 0.6938 0.5991
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.3659 0.3659
Echinococcus granulosus hypothetical protein 0.004 0.2854 0.0644
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.0046 0.3659 0.3659
Echinococcus multilocularis tyrosine protein kinase Src42A 0.009 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.004 0.2854 0.0644
Brugia malayi SH2 domain containing protein 0.0051 0.4451 0.4451
Echinococcus multilocularis tyrosine kinase 0.0051 0.4451 0.2736
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0039 0.2713 0.0459
Brugia malayi E1-E2 ATPase family protein 0.0029 0.1297 0.1297
Brugia malayi Variant SH3 domain containing protein 0.004 0.2854 0.2854
Entamoeba histolytica protein kinase, putative 0.004 0.2854 0.6411
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0022 0.0279 0.0762
Schistosoma mansoni tensin-related 0.004 0.2854 0.0644
Echinococcus multilocularis SHC transforming protein 3 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0051 0.4451 0.2736
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Onchocerca volvulus 0.0069 0.6938 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0046 0.3659 0.1698
Echinococcus granulosus c src tyrosine kinase 0.009 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.009 1 1
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0039 0.2713 0.0459
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.4451 0.4451
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0039 0.2713 0.0459
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0039 0.2713 0.0459
Leishmania major P-type ATPase, putative 0.0037 0.2362 0.4509
Brugia malayi protein-tyrosine kinase 0.0051 0.4451 0.4451
Onchocerca volvulus 0.004 0.2854 0.0334
Schistosoma mansoni tyrosine kinase 0.009 1 1
Brugia malayi hypothetical protein 0.0051 0.4451 0.4451
Echinococcus multilocularis suppressor of cytokine signaling 7 0.004 0.2854 0.0644
Entamoeba histolytica unconventional myosin IB 0.0039 0.2713 0.6094
Echinococcus granulosus SH2 motif 0.004 0.2854 0.0644
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0039 0.2713 0.0459
Trypanosoma brucei P-type H+-ATPase, putative 0.0029 0.1297 0.3012
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0037 0.2362 0.6455
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0037 0.2362 0.4509
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0046 0.3659 0.1698
Schistosoma mansoni GTPase activating protein 0.004 0.2854 0.0644
Echinococcus granulosus Spectrin alpha actinin 0.0039 0.2713 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0046 0.3659 0.8219
Echinococcus multilocularis tyrosine protein kinase shark 0.0051 0.4451 0.2736
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Echinococcus granulosus SH2 motif 0.004 0.2854 0.0644
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0046 0.3659 0.1698
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.2713 0.7415
Echinococcus multilocularis tyrosine protein kinase Srms 0.0051 0.4451 0.2736
Echinococcus granulosus epidermal growth factor receptor kinase 0.0039 0.2713 0.0459
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0079 0.8403 0.7909
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 1 1
Brugia malayi Src substrate cortactin 0.0039 0.2713 0.2713
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0031 0.1576 0.1576
Brugia malayi Protein kinase domain containing protein 0.0051 0.4451 0.4451
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Schistosoma mansoni dreadlocks/dock 0.0039 0.2713 0.0459
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.004 0.2854 0.0334
Schistosoma mansoni formin binding protein and related proteins 0.0039 0.2713 0.0459
Echinococcus granulosus SHC transforming protein 3 0.004 0.2854 0.0644
Brugia malayi Variant SH3 domain containing protein 0.0079 0.8403 0.8403
Trichomonas vaginalis cation-transporting ATPase, putative 0.0046 0.3659 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0046 0.3659 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.2854 0.0644
Brugia malayi SRC-1 0.009 1 1
Schistosoma mansoni apoptosis stimulating of P53 0.0039 0.2713 0.0459
Brugia malayi protein-tyrosine kinase 0.0039 0.2713 0.2713
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Echinococcus multilocularis suppressor of cytokine signaling 6 0.004 0.2854 0.0644
Echinococcus multilocularis intersectin 2 0.0039 0.2713 0.0459
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0046 0.3659 1
Echinococcus multilocularis nostrin 0.0039 0.2713 0.0459
Echinococcus multilocularis SH2 motif 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0046 0.3659 0.3659
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0022 0.0279 0.0279
Brugia malayi Peripheral plasma membrane protein CASK 0.0039 0.2713 0.2713
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0039 0.2713 0.0459
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.2713 0.7415
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Loa Loa (eye worm) STAT protein 0.004 0.2854 0.2854
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Echinococcus multilocularis Spectrin alpha actinin 0.0039 0.2713 0.0459
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0051 0.4451 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.2854 0.0644
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0079 0.8403 0.8403
Brugia malayi SH3 domain containing protein 0.0039 0.2713 0.2713
Schistosoma mansoni tyrosine kinase 0.009 1 1
Echinococcus granulosus fch and double sh3 domains protein 2 0.0039 0.2713 0.0459
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0037 0.2362 0.2362
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.009 1 1
Schistosoma mansoni tensin 0.004 0.2854 0.0644
Brugia malayi Protein kinase domain containing protein 0.0051 0.4451 0.4451
Brugia malayi Spectrin alpha chain 0.0039 0.2713 0.2713
Loa Loa (eye worm) p53BP2 0.0039 0.2713 0.2713
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0046 0.3659 0.1698
Brugia malayi hypothetical protein 0.004 0.2854 0.2854
Entamoeba histolytica protein kinase, putative 0.0039 0.2713 0.6094
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Schistosoma mansoni hypothetical protein 0.0039 0.2713 0.0459
Entamoeba histolytica hypothetical protein, conserved 0.0039 0.2713 0.6094
Schistosoma mansoni sorting nexin 0.0039 0.2713 0.0459
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 1 1
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0069 0.6938 0.5991
Onchocerca volvulus 0.0051 0.4451 0.4115
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 1
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Echinococcus granulosus tyrosine protein kinase Blk 0.0051 0.4451 0.2736
Loa Loa (eye worm) hypothetical protein 0.0079 0.8403 0.8403
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Entamoeba histolytica hypothetical protein, conserved 0.0039 0.2713 0.6094
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0069 0.6938 0.5991
Trypanosoma brucei conserved protein 0.0039 0.2713 0.7201
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0039 0.2713 0.0459
Loa Loa (eye worm) variant SH3 domain-containing protein 0.004 0.2854 0.2854
Echinococcus multilocularis N chimaerin 0.004 0.2854 0.0644
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0079 0.8403 0.8403
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.004 0.2854 0.2854
Loa Loa (eye worm) SRC-1 0.009 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Entamoeba histolytica BAR/SH3 domain containing protein 0.0039 0.2713 0.6094
Echinococcus granulosus tensin 0.004 0.2854 0.0644
Onchocerca volvulus 0.0051 0.4451 0.4115
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.009 1 1
Schistosoma mansoni tensin 0.004 0.2854 0.0644
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0037 0.2362 0.6163
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Brugia malayi STAT protein, DNA binding domain containing protein 0.004 0.2854 0.2854
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Echinococcus multilocularis SH2 domain containing adapter protein F 0.004 0.2854 0.0644
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0046 0.3659 1
Loa Loa (eye worm) guanylate kinase 0.0039 0.2713 0.2713
Echinococcus multilocularis growth factor receptor bound protein 2 0.0079 0.8403 0.7909
Echinococcus multilocularis signal transduction protein lnk realted 0.004 0.2854 0.0644
Echinococcus granulosus SH2 domain containing adapter protein F 0.004 0.2854 0.0644
Trypanosoma brucei P-type H+-ATPase, putative 0.0029 0.1297 0.3012
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0039 0.2713 0.0459
Echinococcus multilocularis SH2 domain containing protein 7 0.004 0.2854 0.0644
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0046 0.3659 0.1698
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.004 0.2854 0.0644
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0031 0.1576 0.5
Brugia malayi Protein kinase domain containing protein 0.0051 0.4451 0.4451
Loa Loa (eye worm) TK/ABL protein kinase 0.0051 0.4451 0.4451
Echinococcus granulosus nostrin 0.0039 0.2713 0.0459
Brugia malayi Na,K-ATPase alpha subunit 0.0046 0.3659 0.3659
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0039 0.2713 0.5995
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0046 0.3659 0.1698
Brugia malayi Fes/CIP4 homology domain containing protein 0.0039 0.2713 0.2713
Echinococcus multilocularis endophilin A3 0.0039 0.2713 0.0459
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0046 0.3659 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.2854 0.0644
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Onchocerca volvulus 0.004 0.2854 0.0334
Brugia malayi Myosin tail family protein 0.0039 0.2713 0.2713
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Loa Loa (eye worm) SH2 domain-containing protein 0.004 0.2854 0.2854
Echinococcus granulosus tyrosine protein kinase Fyn 0.009 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.431 0.2551
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0039 0.2713 0.0459
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0046 0.3659 0.1698
Schistosoma mansoni ATPase 0.0046 0.3659 0.1698
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 1
Echinococcus granulosus SH2 domain containing protein 7 0.004 0.2854 0.0644
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0069 0.6938 0.5991
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0046 0.3659 1
Echinococcus granulosus signal transduction protein lnk realted 0.004 0.2854 0.0644
Echinococcus granulosus endophilin A3 0.0039 0.2713 0.0459
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0046 0.3659 1
Echinococcus multilocularis transfer RNA-Ala 0.0039 0.2713 0.0459
Echinococcus multilocularis nervana 2 0.0069 0.6938 0.5991
Brugia malayi cytokine inducible SH2-containing protein 5 0.004 0.2854 0.2854
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 1 1
Onchocerca volvulus 0.0051 0.4451 0.4115
Schistosoma mansoni adapter molecule crk 0.0079 0.8403 0.7909
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0039 0.2713 0.0459
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0037 0.2362 0.6455
Leishmania major hypothetical protein, conserved 0.0039 0.2713 0.5995
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 0.8219
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0069 0.6938 0.5991
Schistosoma mansoni tyrosine kinase 0.009 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 1 1
Leishmania major calcium-translocating P-type ATPase 0.0046 0.3659 1
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Onchocerca volvulus 0.004 0.2854 0.0334
Loa Loa (eye worm) thyroid receptor interactor 0.0039 0.2713 0.2713
Echinococcus multilocularis tensin 0.004 0.2854 0.0644
Schistosoma mansoni hypothetical protein 0.0039 0.2713 0.0459
Schistosoma mansoni tyrosine kinase 0.0051 0.4451 0.2736
Schistosoma mansoni vav2 0.004 0.2854 0.0644
Brugia malayi Protein kinase domain containing protein 0.0051 0.4451 0.4451
Brugia malayi Variant SH3 domain containing protein 0.0079 0.8403 0.8403
Schistosoma mansoni C-fyn 0.0039 0.2713 0.0459
Schistosoma mansoni dynamin-associated protein 0.0039 0.2713 0.0459
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Echinococcus granulosus NCK adaptor protein 0.0079 0.8403 0.7909
Echinococcus multilocularis suppressor of cytokine signaling 7 0.004 0.2854 0.0644
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0039 0.2713 0.0459
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.004 0.2854 0.0644
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0026 0.0823 0.1848
Onchocerca volvulus 0.0069 0.6938 1
Echinococcus multilocularis SH2 motif 0.004 0.2854 0.0644
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0046 0.3659 1
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0046 0.3659 1
Echinococcus multilocularis tensin 0.004 0.2854 0.0644
Loa Loa (eye worm) SH2 domain-containing protein 0.004 0.2854 0.2854
Schistosoma mansoni cell polarity protein 0.0039 0.2713 0.0459
Loa Loa (eye worm) hypothetical protein 0.0069 0.6938 0.6938
Onchocerca volvulus 0.004 0.2854 0.0334
Echinococcus granulosus growth factor receptor bound protein 2 0.0079 0.8403 0.7909
Entamoeba histolytica SH2-protein kinase domain containing protein 0.004 0.2854 0.6411
Trypanosoma cruzi P-type H+-ATPase, putative 0.0029 0.1297 0.3545
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0039 0.2713 0.2713
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0046 0.3659 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Schistosoma mansoni signal transduction protein lnk-related 0.004 0.2854 0.0644
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.2713 0.7415
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0039 0.2713 0.0459
Brugia malayi Membrane calcium atpase protein 3 0.0037 0.2362 0.2362
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 0.8219
Trypanosoma brucei calcium-translocating P-type ATPase 0.0037 0.2362 0.6163
Schistosoma mansoni nck2/grb4 0.0079 0.8403 0.7909
Schistosoma mansoni SH2A 0.004 0.2854 0.0644
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.009 1 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0046 0.3659 1
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0039 0.2713 0.0459
Echinococcus granulosus suppressor of cytokine signaling 6 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.0069 0.6938 0.6938
Echinococcus granulosus expressed conserved protein 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Onchocerca volvulus 0.0051 0.4451 0.4115
Echinococcus granulosus tyrosine protein kinase Src42A 0.009 1 1
Schistosoma mansoni ATPase 0.0046 0.3659 0.1698
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Echinococcus multilocularis c src tyrosine kinase 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Plasmodium vivax P-type ATPase4, putative 0.0046 0.3659 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0079 0.8403 0.7909
Echinococcus multilocularis SH2 motif 0.004 0.2854 0.0644
Leishmania major calcium-transporting ATPase, putative 0.0037 0.2362 0.4509
Echinococcus granulosus suppressor of cytokine signaling 7 0.004 0.2854 0.0644
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0051 0.4451 0.2736
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Onchocerca volvulus 0.0051 0.4451 0.4115
Echinococcus multilocularis nervana 2 0.0069 0.6938 0.5991
Schistosoma mansoni Dab2-interacting protein-like 0.0039 0.2713 0.0459
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.009 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.009 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.004 0.2854 0.2854
Plasmodium vivax calcium-transporting ATPase, putative 0.0046 0.3659 0.5
Onchocerca volvulus 0.0046 0.3659 0.2239
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0037 0.2362 0.6455
Brugia malayi tRNA modification GTPase TrmE family protein 0.004 0.2854 0.2854
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2713 0.5995
Trypanosoma cruzi P-type H+-ATPase, putative 0.0029 0.1297 0.3545
Echinococcus granulosus tyrosine protein kinase Lyn 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Echinococcus multilocularis NCK adaptor protein 0.0079 0.8403 0.7909
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0046 0.3659 1
Echinococcus multilocularis expressed protein 0.0039 0.2713 0.0459
Onchocerca volvulus 0.004 0.2854 0.0334
Schistosoma mansoni tensin-related 0.004 0.2854 0.0644
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0069 0.6938 0.5991
Schistosoma mansoni hypothetical protein 0.004 0.2854 0.0644
Loa Loa (eye worm) protein-tyrosine kinase 0.0039 0.2713 0.2713
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.2713 0.2713
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.004 0.2854 0.0644
Brugia malayi RhoGAP domain containing protein 0.004 0.2854 0.2854
Toxoplasma gondii P-type ATPase4, putative 0.0046 0.3659 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0051 0.4451 0.2736
Echinococcus multilocularis 0.004 0.2854 0.0644
Echinococcus granulosus tyrosine protein kinase shark 0.0051 0.4451 0.2736
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.004 0.2854 0.0644
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0046 0.3659 1
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Schistosoma mansoni tyrosine-protein kinase zap-70 0.004 0.2854 0.0644
Leishmania major calcium motive p-type ATPase, putative 0.0037 0.2362 0.4509
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.004 0.2854 0.0644
Echinococcus granulosus nervana 2 0.0069 0.6938 0.5991
Brugia malayi Sex muscle abnormal protein 5 0.0079 0.8403 0.8403
Schistosoma mansoni suppressor of cytokine signaling 0.004 0.2854 0.0644
Echinococcus granulosus tyrosine protein kinase ABL1 0.0051 0.4451 0.2736
Schistosoma mansoni run and tbc1 domain containing 0.0039 0.2713 0.0459
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.4451 0.4451
Echinococcus granulosus src region 0.0039 0.2713 0.0459
Brugia malayi Tensin 0.004 0.2854 0.2854
Echinococcus granulosus intersectin 2 0.0039 0.2713 0.0459
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0039 0.2713 0.7415
Brugia malayi Variant SH3 domain containing protein 0.0039 0.2713 0.2713
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0046 0.3659 0.8219
Echinococcus multilocularis nervana 2 0.0069 0.6938 0.5991
Schistosoma mansoni eps8-related protein 0.0039 0.2713 0.0459
Echinococcus multilocularis tyrosine protein kinase Fgr 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0069 0.6938 0.5991
Brugia malayi Variant SH3 domain containing protein 0.004 0.2854 0.2854
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0031 0.1576 0.1576
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.2854 0.0644
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0046 0.3659 1
Brugia malayi SH2 domain containing protein 0.004 0.2854 0.2854
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.2854 0.2854
Schistosoma mansoni transmemberane protein 0.0069 0.6938 0.5991
Loa Loa (eye worm) calcium ATPase 0.0026 0.0823 0.0823
Brugia malayi Guanylate kinase family protein 0.0039 0.2713 0.2713
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.2854 0.0644
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0046 0.3659 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0039 0.2713 0.0459
Entamoeba histolytica hypothetical protein 0.0039 0.2713 0.6094
Schistosoma mansoni hypothetical protein 0.004 0.2854 0.0644
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0051 0.4451 0.2736
Schistosoma mansoni tensin 0.004 0.2854 0.0644
Schistosoma mansoni tyrosine kinase 0.0051 0.4451 0.2736
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.009 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0079 0.8403 0.7909
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0022 0.0279 0.0279
Echinococcus granulosus nervana 2 0.0069 0.6938 0.5991
Echinococcus granulosus tyrosine kinase 0.0051 0.4451 0.2736
Loa Loa (eye worm) RhoGAP domain-containing protein 0.004 0.2854 0.2854
Toxoplasma gondii P-type ATPase PMA1 0.0029 0.1297 0.3545
Schistosoma mansoni tyrosine kinase 0.009 1 1
Trichomonas vaginalis p67phox protein, putative 0.0039 0.2713 0.5995
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0039 0.2713 0.0459
Echinococcus granulosus N chimaerin 0.004 0.2854 0.0644
Onchocerca volvulus 0.0051 0.4451 0.4115
Echinococcus granulosus tyrosine kinase 0.0051 0.4451 0.2736
Loa Loa (eye worm) hypothetical protein 0.0039 0.2713 0.2713
Loa Loa (eye worm) hypothetical protein 0.004 0.2854 0.2854
Schistosoma mansoni shc transforming protein 0.004 0.2854 0.0644

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) ND 0 ug ml-1 Compound was tested for cytotoxicity in Vero cells; ND denotes ''Not determined'' ChEMBL. 15771444
MIC (functional) > 6.25 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444
MIC (functional) > 6.25 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444
SI (ADMET) ND 0 ug ml-1 Selectivity index (ratio of IC50 and MIC) value of the compound was determined; ND denotes ''Not determined'' ChEMBL. 15771444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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