Detailed information for compound 311096

Basic information

Technical information
  • TDR Targets ID: 311096
  • Name: (Z)-1-(4,5-diphenyl-1,3-oxazol-2-yl)octadec-9 -en-1-one
  • MW: 485.7 | Formula: C33H43NO2
  • H donors: 0 H acceptors: 2 LogP: 11.16 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)c1nc(c(o1)c1ccccc1)c1ccccc1
  • InChi: 1S/C33H43NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-22-27-30(35)33-34-31(28-23-18-16-19-24-28)32(36-33)29-25-20-17-21-26-29/h9-10,16-21,23-26H,2-8,11-15,22,27H2,1H3/b10-9-
  • InChiKey: FHWUGULPJAFRLM-KTKRTIGZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-1-(4,5-diphenyloxazol-2-yl)octadec-9-en-1-one
  • (Z)-1-(4,5-diphenyl-2-oxazolyl)-9-octadecen-1-one
  • (Z)-1-[4,5-di(phenyl)-1,3-oxazol-2-yl]octadec-9-en-1-one
  • (Z)-1-[4,5-di(phenyl)oxazol-2-yl]octadec-9-en-1-one
  • (Z)-1-[4,5-di(phenyl)-2-oxazolyl]octadec-9-en-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0049 0.295 0.295
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0049 0.295 0.295
Plasmodium falciparum protein disulfide isomerase 0.0023 0 0.5
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0048 0.281 0.281
Echinococcus granulosus fch and double sh3 domains protein 2 0.0048 0.281 0.281
Onchocerca volvulus 0.0063 0.4526 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0049 0.295 0.295
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0097 0.8424 0.8424
Echinococcus granulosus c src tyrosine kinase 0.0111 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.281 0.281
Entamoeba histolytica protein kinase, putative 0.0048 0.281 0.621
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0048 0.281 0.281
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0048 0.281 0.281
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0049 0.295 0.295
Entamoeba histolytica protein kinase, putative 0.0049 0.295 0.6517
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.295 0.295
Echinococcus granulosus growth factor receptor bound protein 2 0.0097 0.8424 0.8424
Loa Loa (eye worm) STAT protein 0.0049 0.295 0.295
Schistosoma mansoni tensin 0.0049 0.295 0.295
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0111 1 1
Brugia malayi Variant SH3 domain containing protein 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Leishmania major hypothetical protein, conserved 0.0048 0.281 1
Schistosoma mansoni dreadlocks/dock 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Brugia malayi hypothetical protein 0.0049 0.295 0.295
Schistosoma mansoni Dab2-interacting protein-like 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase shark 0.0063 0.4526 0.4526
Loa Loa (eye worm) thyroid receptor interactor 0.0048 0.281 0.281
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.281 1
Loa Loa (eye worm) guanylate kinase 0.0048 0.281 0.281
Brugia malayi RhoGAP domain containing protein 0.0049 0.295 0.295
Brugia malayi hypothetical protein 0.0063 0.4526 0.4526
Toxoplasma gondii protein disulfide isomerase-related protein (provisional), putative 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 1 1
Echinococcus multilocularis endophilin A3 0.0048 0.281 0.281
Brugia malayi SH2 domain containing protein 0.0063 0.4526 0.4526
Schistosoma mansoni nck2/grb4 0.0097 0.8424 0.8424
Entamoeba histolytica SH2 domain containing protein 0.0049 0.295 0.6517
Schistosoma mansoni sorting nexin 0.0048 0.281 0.281
Schistosoma mansoni vav2 0.0049 0.295 0.295
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0111 1 1
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.295 0.295
Schistosoma mansoni tyrosine kinase 0.0111 1 1
Onchocerca volvulus 0.0063 0.4526 1
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.8424 0.8424
Schistosoma mansoni dynamin-associated protein 0.0048 0.281 0.281
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Onchocerca volvulus 0.0049 0.295 0.0812
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.295 0.295
Brugia malayi Protein kinase domain containing protein 0.0063 0.4526 0.4526
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Schistosoma mansoni C-fyn 0.0048 0.281 0.281
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0049 0.295 0.0812
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Schistosoma mansoni SH2A 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 1 1
Echinococcus multilocularis SH2 motif 0.0049 0.295 0.295
Brugia malayi Variant SH3 domain containing protein 0.0049 0.295 0.295
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0111 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0063 0.4526 0.4526
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Echinococcus multilocularis 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus multilocularis tyrosine protein kinase Srms 0.0063 0.4526 0.4526
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.4386 0.4386
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.295 0.295
Schistosoma mansoni shc transforming protein 0.0049 0.295 0.295
Schistosoma mansoni tensin-related 0.0049 0.295 0.295
Onchocerca volvulus 0.0049 0.295 0.0812
Echinococcus multilocularis tyrosine protein kinase Abl 0.0111 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0063 0.4526 1
Schistosoma mansoni cell polarity protein 0.0048 0.281 0.281
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0111 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.4526 0.4526
Echinococcus multilocularis signal transduction protein lnk realted 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase Blk 0.0063 0.4526 0.4526
Echinococcus multilocularis SH2 domain containing protein 7 0.0049 0.295 0.295
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus multilocularis expressed protein 0.0048 0.281 0.281
Echinococcus multilocularis SH2 motif 0.0049 0.295 0.295
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0049 0.295 0.0812
Brugia malayi Protein kinase domain containing protein 0.0063 0.4526 0.4526
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.281 0.281
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0111 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0049 0.295 0.295
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.281 0.621
Echinococcus granulosus nostrin 0.0048 0.281 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0048 0.281 0.281
Schistosoma mansoni tensin 0.0049 0.295 0.295
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase Lyn 0.0111 1 1
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0048 0.281 0.281
Echinococcus granulosus tyrosine protein kinase Src64B 0.0111 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Brugia malayi Protein kinase domain containing protein 0.0063 0.4526 0.4526
Echinococcus granulosus tyrosine kinase 0.0063 0.4526 0.4526
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.281 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Schistosoma mansoni tyrosine kinase 0.0111 1 1
Trichomonas vaginalis p67phox protein, putative 0.0048 0.281 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0111 1 1
Onchocerca volvulus 0.0063 0.4526 1
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0048 0.281 0.281
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.295 0.6517
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Brugia malayi SH3 domain containing protein 0.0048 0.281 0.281
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0048 0.281 0.281
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.295 0.295
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.295 0.295
Brugia malayi cytokine inducible SH2-containing protein 5 0.0049 0.295 0.295
Echinococcus multilocularis growth factor receptor bound protein 2 0.0097 0.8424 0.8424
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Brugia malayi SRC-1 0.0111 1 1
Schistosoma mansoni hypothetical protein 0.0049 0.295 0.295
Brugia malayi STAT protein, DNA binding domain containing protein 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0097 0.8424 0.8424
Echinococcus granulosus SH2 motif 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase ABL1 0.0063 0.4526 0.4526
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus granulosus expressed conserved protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 1 1
Schistosoma mansoni tensin-related 0.0049 0.295 0.295
Loa Loa (eye worm) SRC-1 0.0111 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.295 0.295
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0097 0.8424 0.8424
Schistosoma mansoni sorbin 0.0048 0.281 0.281
Echinococcus granulosus src region 0.0048 0.281 0.281
Brugia malayi tRNA modification GTPase TrmE family protein 0.0049 0.295 0.295
Onchocerca volvulus 0.0063 0.4526 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Onchocerca volvulus 0.0063 0.4526 1
Loa Loa (eye worm) TK protein kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0063 0.4526 0.4526
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.295 0.295
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0111 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 1 1
Schistosoma mansoni apoptosis stimulating of P53 0.0048 0.281 0.281
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0111 1 1
Brugia malayi protein-tyrosine kinase 0.0048 0.281 0.281
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.295 0.295
Brugia malayi Sex muscle abnormal protein 5 0.0097 0.8424 0.8424
Loa Loa (eye worm) p53BP2 0.0048 0.281 0.281
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0048 0.281 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Schistosoma mansoni tyrosine kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis tyrosine protein kinase shark 0.0063 0.4526 0.4526
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.295 0.295
Echinococcus granulosus epidermal growth factor receptor kinase 0.0048 0.281 0.281
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.295 0.295
Echinococcus granulosus intersectin 2 0.0048 0.281 0.281
Onchocerca volvulus 0.0049 0.295 0.0812
Echinococcus granulosus suppressor of cytokine signaling 7 0.0049 0.295 0.295
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0049 0.295 0.295
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0063 0.4526 0.4526
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0049 0.295 0.295
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.295 0.295
Echinococcus multilocularis SH2 motif 0.0049 0.295 0.295
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0048 0.281 0.281
Echinococcus granulosus signal transduction protein lnk realted 0.0049 0.295 0.295
Schistosoma mansoni adapter molecule crk 0.0097 0.8424 0.8424
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0049 0.295 0.295
Brugia malayi Protein kinase domain containing protein 0.0063 0.4526 0.4526
Echinococcus multilocularis Spectrin alpha actinin 0.0048 0.281 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Brugia malayi Fes/CIP4 homology domain containing protein 0.0048 0.281 0.281
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.295 0.295
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0111 1 1
Echinococcus granulosus Spectrin alpha actinin 0.0048 0.281 0.281
Schistosoma mansoni hypothetical protein 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Echinococcus granulosus SH2 motif 0.0049 0.295 0.295
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0048 0.281 1
Echinococcus granulosus tensin 0.0049 0.295 0.295
Loa Loa (eye worm) TK/ABL protein kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis NCK adaptor protein 0.0097 0.8424 0.8424
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Echinococcus granulosus tyrosine protein kinase Src42A 0.0111 1 1
Echinococcus multilocularis tyrosine kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0111 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.295 0.295
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0063 0.4526 0.4526
Loa Loa (eye worm) protein-tyrosine kinase 0.0048 0.281 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.281 1
Brugia malayi Peripheral plasma membrane protein CASK 0.0048 0.281 0.281
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Brugia malayi SH2 domain containing protein 0.0063 0.4526 0.4526
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Brugia malayi Tensin 0.0049 0.295 0.295
Echinococcus granulosus expressed protein 0.0048 0.281 0.281
Brugia malayi Variant SH3 domain containing protein 0.0097 0.8424 0.8424
Schistosoma mansoni run and tbc1 domain containing 0.0048 0.281 0.281
Echinococcus multilocularis intersectin 2 0.0048 0.281 0.281
Onchocerca volvulus 0.0049 0.295 0.0812
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0111 1 1
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Trypanosoma brucei conserved protein 0.0048 0.281 1
Schistosoma mansoni GTPase activating protein 0.0049 0.295 0.295
Schistosoma mansoni tensin 0.0049 0.295 0.295
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0048 0.281 0.281
Brugia malayi Variant SH3 domain containing protein 0.0097 0.8424 0.8424
Echinococcus granulosus SH2 domain containing protein 7 0.0049 0.295 0.295
Schistosoma mansoni eps8-related protein 0.0048 0.281 0.281
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.281 0.281
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Schistosoma mansoni signal transduction protein lnk-related 0.0049 0.295 0.295
Brugia malayi Guanylate kinase family protein 0.0048 0.281 0.281
Onchocerca volvulus 0.0049 0.295 0.0812
Onchocerca volvulus 0.0063 0.4526 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0049 0.295 0.295
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0048 0.281 1
Echinococcus multilocularis transfer RNA-Ala 0.0048 0.281 0.281
Schistosoma mansoni tyrosine kinase 0.0111 1 1
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.295 0.295
Entamoeba histolytica hypothetical protein 0.0048 0.281 0.621
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.295 0.295
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0049 0.295 0.295
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0049 0.295 0.295
Echinococcus granulosus SHC transforming protein 3 0.0049 0.295 0.295
Brugia malayi Myosin tail family protein 0.0048 0.281 0.281
Echinococcus multilocularis tensin 0.0049 0.295 0.295
Schistosoma mansoni formin binding protein and related proteins 0.0048 0.281 0.281
Echinococcus granulosus endophilin A3 0.0048 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0063 0.4526 0.4526
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.295 0.295
Plasmodium vivax protein disulfide isomerase, putative 0.0023 0 0.5
Schistosoma mansoni tyrosine kinase 0.0063 0.4526 0.4526
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.281 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 1 1
Onchocerca volvulus 0.0049 0.295 0.0812
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0097 0.8424 0.8424
Brugia malayi Variant SH3 domain containing protein 0.0048 0.281 0.281
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0048 0.281 0.281
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0049 0.295 0.295
Loa Loa (eye worm) hypothetical protein 0.0048 0.281 0.281
Echinococcus multilocularis c src tyrosine kinase 0.0111 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Schistosoma mansoni tyrosine kinase 0.0111 1 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0049 0.295 0.295
Brugia malayi Protein kinase domain containing protein 0.0063 0.4526 0.4526
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.8424 0.8424
Echinococcus granulosus N chimaerin 0.0049 0.295 0.295
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.281 0.621
Brugia malayi protein-tyrosine kinase 0.0063 0.4526 0.4526
Echinococcus multilocularis nostrin 0.0048 0.281 0.281
Brugia malayi Src substrate cortactin 0.0048 0.281 0.281
Brugia malayi SH2 domain containing protein 0.0049 0.295 0.295
Entamoeba histolytica unconventional myosin IB 0.0048 0.281 0.621
Echinococcus granulosus NCK adaptor protein 0.0097 0.8424 0.8424
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0063 0.4526 0.4526
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.281 0.281
Schistosoma mansoni hypothetical protein 0.0048 0.281 0.281
Echinococcus granulosus hypothetical protein 0.0049 0.295 0.295
Echinococcus granulosus tyrosine protein kinase Srms 0.0063 0.4526 0.4526
Brugia malayi Spectrin alpha chain 0.0048 0.281 0.281
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0049 0.295 0.295
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.4526 0.4526
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.281 0.621
Echinococcus multilocularis tensin 0.0049 0.295 0.295
Echinococcus multilocularis N chimaerin 0.0049 0.295 0.295
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.281 0.621

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 100 uM Inhibitory constant determined against recombinant Fatty-acid amide hydrolase from rat expressed in Escherichia coli ChEMBL. 15771430
Ki (binding) > 100 uM Inhibitory constant determined against recombinant Fatty-acid amide hydrolase from rat expressed in Escherichia coli ChEMBL. 15771430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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