TDR Targets

Basic information

Technical information

TDR Targets ID: 311427
Name: 2-(2,6-dichloroanilino)-6-methyl-6-(2-methylp ropyl)-3H-imidazo[4,5-h]isoquinoline-7,9-dion e
MW: 431.315 | Formula: C21H20Cl2N4O2
H donors: 3 H acceptors: 3 LogP: 5.43 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC1(C)C(=O)NC(=O)c2c1ccc1c2nc([nH]1)Nc1c(Cl)cccc1Cl)C
InChi: 1S/C21H20Cl2N4O2/c1-10(2)9-21(3)11-7-8-14-17(15(11)18(28)27-19(21)29)26-20(24-14)25-16-12(22)5-4-6-13(16)23/h4-8,10H,9H2,1-3H3,(H2,24,25,26)(H,27,28,29)
InChiKey: STSXYWPNJGCBFG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,6-dichloroanilino)-6-isobutyl-6-methyl-3H-imidazo[4,5-h]isoquinoline-7,9-dione
2-[(2,6-dichlorophenyl)amino]-6-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-h]isoquinoline-7,9-dione
2-(2,6-dichloroanilino)-6-isobutyl-6-methyl-3H-imidazo[4,5-h]isoquinoline-7,9-quinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SRC-1	0.001	0.0049	0.0049
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0493	0.0939
Onchocerca volvulus		0.0478	0.5222	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Loa Loa (eye worm)	hypothetical protein	0.0328	0.3565	0.3565
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0108	0.1135	0.1135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Plasmodium falciparum	serine repeat antigen 6	0.0108	0.1135	0.217
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0493	0.0493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.5222	1
Schistosoma mansoni	tyrosine kinase	0.001	0.0049	0.0049
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0157	0.0297
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0356	0.3877	0.7422
Brugia malayi	calpain family protein 1	0.0053	0.0523	0.0523
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0493	0.0493
Echinococcus granulosus	tyrosine protein kinase Src42A	0.001	0.0049	0.0049
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0108	0.1135	0.193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.2792	0.5344
Echinococcus multilocularis	calpain family protein 1, d	0.0039	0.0368	0.0368
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0155
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.5222	0.5222
Echinococcus multilocularis	cathepsin b	0.091	1	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.1135	0.217
Plasmodium vivax	vivapain-2	0.0478	0.5222	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0456	0.0456
Onchocerca volvulus		0.0328	0.3565	0.6827
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Echinococcus granulosus	gamma secretase subunit aph 1	0.0725	0.7958	0.7958
Loa Loa (eye worm)	fibroinase	0.0478	0.5222	0.5222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.2792	0.5344
Trypanosoma cruzi	kinesin, putative	0.0014	0.0091	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.1135	0.217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0523	0.0523
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.5222	0.5221
Trypanosoma brucei	Aph-1 protein, putative	0.0283	0.3061	0.5861
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Schistosoma mansoni	calpain-7 (C02 family)	0.002	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Onchocerca volvulus		0.0478	0.5222	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0108	0.1135	0.1135
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0493	0.0939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Leishmania major	cysteine peptidase A (CPA)	0.0478	0.5222	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.015	0.1593	0.1593
Plasmodium falciparum	serine repeat antigen 9	0.0108	0.1135	0.217
Brugia malayi	Papain family cysteine protease containing protein	0.0258	0.2792	0.2792
Giardia lamblia	Cysteine protease	0.0108	0.1135	0.1898
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0478	0.5222	0.5222
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Echinococcus multilocularis	hypothetical protein	0.002	0.0157	0.0157
Brugia malayi	calpain 7	0.002	0.0157	0.0157
Leishmania major	kinesin, putative	0.0014	0.0091	0.0169
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0049	0.0049
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.5222	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0108	0.1135	0.193
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0258	0.2792	0.2792
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Loa Loa (eye worm)	calpain 5	0.0014	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.2792	0.5344
Brugia malayi	calpain D	0.0006	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0155
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0155
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.2792	0.5346
Plasmodium vivax	vivapain-2	0.0478	0.5222	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0108	0.1135	0.193
Loa Loa (eye worm)	hypothetical protein	0.015	0.1593	0.1593
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0328	0.3565	0.3565
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.1135	0.217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Onchocerca volvulus		0.0478	0.5222	1
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1593	0.1591
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0035	0.0035
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Schistosoma mansoni	tyrosine kinase	0.001	0.0049	0.0049
Trypanosoma cruzi	Aph-1 protein, putative	0.0283	0.3061	0.306
Loa Loa (eye worm)	hypothetical protein	0.0328	0.3565	0.3565
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.2792	0.5346
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0493	0.0939
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0493	0.049
Giardia lamblia	Cathepsin B precursor	0.0108	0.1135	0.1898
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.001	0.0049	0.0049
Brugia malayi	MAP kinase sur-1	0.005	0.0493	0.0493
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0108	0.1135	0.193
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.2792	0.5346
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0478	0.5222	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0108	0.1135	0.1135
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0493	0.0939
Echinococcus multilocularis	cysteine protease	0.0478	0.5222	0.5222
Plasmodium vivax	serine-repeat antigen (SERA)	0.0108	0.1135	0.193
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0493	0.049
Echinococcus multilocularis	calpain 5	0.002	0.0157	0.0157
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.055	0.055
Giardia lamblia	Hypothetical protein	0.0108	0.1135	0.1898
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0328	0.3565	0.3564
Entamoeba histolytica	hypothetical protein	0.0108	0.1135	0.2173
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0297
Schistosoma mansoni	tyrosine kinase	0.001	0.0049	0.0049
Echinococcus granulosus	calpain 5	0.002	0.0157	0.0157
Schistosoma mansoni	cathepsin F (C01 family)	0.0328	0.3565	0.3565
Giardia lamblia	Cathepsin B precursor	0.0108	0.1135	0.1898
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0297
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.5222	1
Schistosoma mansoni	calpain-7 (C02 family)	0.002	0.0157	0.0157
Plasmodium vivax	vivapain-1	0.0258	0.2792	0.5202
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0014	0.0091	0.0173
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.091	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.1135	0.217
Trypanosoma brucei	protein kinase, putative	0.005	0.0493	0.0939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0108	0.1135	0.217
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0035	0.0035
Onchocerca volvulus	Cathepsin F homolog	0.0478	0.5222	1
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Echinococcus multilocularis	calpain	0.002	0.0157	0.0157
Echinococcus multilocularis	calpain 7 (C02 family)	0.002	0.0157	0.0157
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0108	0.1135	0.2173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Toxoplasma gondii	cathepsin CPC2	0.0108	0.1135	0.217
Plasmodium vivax	unspecified product	0.0108	0.1135	0.193
Plasmodium falciparum	serine repeat antigen 2	0.0108	0.1135	0.217
Giardia lamblia	Cysteine protease	0.0108	0.1135	0.1898
Loa Loa (eye worm)	ctsf protein	0.0478	0.5222	0.5222
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.1135	0.1135
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0478	0.5222	0.5222
Schistosoma mansoni	adapter molecule crk	0.0009	0.0035	0.0035
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.015	0.1593	0.1593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Schistosoma mansoni	calpain-2 (C02 family)	0.0006	0.0002	0.0002
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0049	0.0049
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Toxoplasma gondii	cathepsin CPL	0.0478	0.5222	1
Loa Loa (eye worm)	calpain family protein 1	0.0039	0.0368	0.0368
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Giardia lamblia	Cathepsin L-like protease	0.0108	0.1135	0.1898
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0108	0.1135	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1135	0.217
Echinococcus multilocularis	calpain A	0.0055	0.055	0.055
Giardia lamblia	Cathepsin L-like protease	0.0108	0.1135	0.1898
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.015	0.1593	0.1593
Plasmodium falciparum	serine repeat antigen 8	0.0108	0.1135	0.217
Trypanosoma cruzi	major cysteine proteinase, putative	0.0108	0.1135	0.1133
Trypanosoma cruzi	major cysteine proteinase, putative	0.0108	0.1135	0.1133
Echinococcus multilocularis	cathepsin b	0.091	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0035
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.001	0.0049	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Giardia lamblia	Cathepsin B precursor	0.0108	0.1135	0.1898
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0108	0.1135	0.217
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0356	0.3877	0.7422
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Brugia malayi	Cathepsin L-like precursor	0.015	0.1593	0.1593
Entamoeba histolytica	cysteine proteinase, putative	0.0328	0.3565	0.6827
Brugia malayi	cathepsin L-like cysteine proteinase	0.0108	0.1135	0.1135
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Giardia lamblia	Cathepsin B precursor	0.0356	0.3877	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.5222	0.5221
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0155
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0258	0.2792	0.2792
Trypanosoma cruzi	kinesin, putative	0.0014	0.0091	0.0088
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.1135	0.1898
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Schistosoma mansoni	nck2/grb4	0.0009	0.0035	0.0035
Echinococcus granulosus	calpain A	0.0055	0.055	0.055
Onchocerca volvulus		0.0478	0.5222	1
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0478	0.5222	0.5222
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0328	0.3565	0.3565
Onchocerca volvulus		0.0478	0.5222	1
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.2792	0.5346
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0157	0.0297
Toxoplasma gondii	cathepsin B	0.0356	0.3877	0.7422
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0108	0.1135	0.193
Echinococcus granulosus	cathepsin L	0.0258	0.2792	0.2792
Loa Loa (eye worm)	cathepsin B	0.0356	0.3877	0.3877
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0108	0.1135	0.217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Echinococcus granulosus	cathepsin l1	0.0478	0.5222	0.5222
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.055	0.055
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.5222	0.5222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0258	0.2792	0.5346
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0049	0.0049
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0478	0.5222	0.5222
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Entamoeba histolytica	protein kinase, putative	0.0014	0.0096	0.0183
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.3877	0.7422
Trypanosoma brucei	antigen, putative	0.002	0.0157	0.0297
Plasmodium vivax	serine-repeat antigen (SERA)	0.0108	0.1135	0.193
Brugia malayi	cathepsin L-like precursor	0.0328	0.3565	0.3565
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.1135	0.1898
Entamoeba histolytica	cysteine proteinase 2	0.0258	0.2792	0.5346
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.001	0.0049	0.0049
Trypanosoma cruzi	cruzipain precursor, putative	0.015	0.1593	0.1591
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1135	0.217
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0002
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0108	0.1135	0.1135
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0108	0.1135	0.193
Schistosoma mansoni	calpain C (C02 family)	0.002	0.0157	0.0157
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0108	0.1135	0.217
Loa Loa (eye worm)	hypothetical protein	0.091	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0328	0.3565	0.6826
Schistosoma mansoni	cathepsin C	0.0108	0.1135	0.1135
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.5222	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0258	0.2792	0.5344
Giardia lamblia	Cysteine protease	0.0108	0.1135	0.1898
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1135	0.1135
Loa Loa (eye worm)	calpain D	0.0006	0.0002	0.0002
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0108	0.1135	0.193
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0155
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0035	0.0035
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.001	0.0049	0.0049
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.055	0.055
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0493	0.0939
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.5222	1
Entamoeba histolytica	cysteine protease, putative	0.0478	0.5222	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0108	0.1135	0.1135
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1135	0.1135
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0493	0.0939
Loa Loa (eye worm)	hypothetical protein	0.015	0.1593	0.1593
Onchocerca volvulus	Cathepsin L homolog	0.0108	0.1135	0.2173
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0725	0.7958	0.7958
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0035	0.0035
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.3877	0.3877
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0155
Schistosoma mansoni	cathepsin B (C01 family)	0.0108	0.1135	0.1135
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0258	0.2792	0.279
Plasmodium vivax	unspecified product	0.0258	0.2792	0.5202
Plasmodium vivax	unspecified product	0.015	0.1593	0.2834
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0493	0.049
Schistosoma mansoni	hypothetical protein	0.0006	0.0002	0.0002
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.1135	0.217
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.1135	0.1898
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.5222	0.5222
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0493	0.0939
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0155
Schistosoma mansoni	Mername-AA248 (C02 family)	0.002	0.0157	0.0157
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0155
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0108	0.1135	0.217
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.5222	0.5221
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.001	0.0049	0.0049
Plasmodium falciparum	serine repeat antigen 1	0.0108	0.1135	0.217
Echinococcus granulosus	calpain	0.002	0.0157	0.0157
Trypanosoma cruzi	cruzipain precursor, putative	0.0478	0.5222	0.5221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0108	0.1135	0.193
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Loa Loa (eye worm)	calpain	0.002	0.0157	0.0157
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.091	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.5222	0.5222
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Brugia malayi	calpain family protein 1	0.0053	0.0523	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Echinococcus granulosus	cathepsin L	0.0108	0.1135	0.1135
Giardia lamblia	Cathepsin B precursor	0.0108	0.1135	0.1898
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0725	0.7958	0.7958
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Onchocerca volvulus		0.0033	0.0301	0.0577
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Plasmodium falciparum	serine repeat antigen 7	0.0108	0.1135	0.217
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0049	0.0049
Brugia malayi	cathepsin L precursor	0.0108	0.1135	0.1135
Plasmodium falciparum	serine repeat antigen 4	0.0108	0.1135	0.217
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Plasmodium falciparum	serine repeat antigen 5	0.0108	0.1135	0.217
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0108	0.1135	0.1135
Echinococcus granulosus	cathepsin b	0.091	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.1135	0.217
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0049	0.0049
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0108	0.1135	0.1135
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0157	0.0297
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1135	0.1135
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0108	0.1135	0.1135
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.5222	0.5221
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0368	0.0368
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0108	0.1135	0.1135
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.091	1	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0297
Echinococcus multilocularis	cathepsin L	0.0108	0.1135	0.1135
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0108	0.1135	0.1898
Echinococcus granulosus	cathepsin b	0.091	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0258	0.2792	0.279
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1135	0.2173
Brugia malayi	gamma-secretase subunit aph-1	0.0725	0.7958	0.7958
Onchocerca volvulus		0.0108	0.1135	0.2173
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.1135	0.217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.5222	0.5222
Trypanosoma cruzi	cysteine proteinase, putative	0.0258	0.2792	0.279
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0108	0.1135	0.1135
Echinococcus granulosus	cysteine protease	0.0258	0.2792	0.2792
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.2792	0.5344
Onchocerca volvulus		0.0478	0.5222	1
Loa Loa (eye worm)	cysteine protease	0.0478	0.5222	0.5222
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Echinococcus granulosus	cathepsin l1	0.0328	0.3565	0.3565
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0493	0.0493
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0108	0.1135	0.217
Echinococcus multilocularis	cysteine protease	0.0478	0.5222	0.5222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Echinococcus multilocularis	cathepsin L	0.0258	0.2792	0.2792
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.002	0.0157	0.0155
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0035	0.0035
Echinococcus granulosus	calpain 7 C02 family	0.002	0.0157	0.0157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0108	0.1135	0.1135
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Plasmodium vivax	vivapain-3	0.0258	0.2792	0.5202
Schistosoma mansoni	tyrosine kinase	0.001	0.0049	0.0049
Giardia lamblia	Hypothetical protein	0.0108	0.1135	0.1898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.5222	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0011	0.0054	0.0054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0108	0.1135	0.193
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Trypanosoma cruzi	Aph-1 protein, putative	0.0283	0.3061	0.306
Brugia malayi	Papain family cysteine protease containing protein	0.0478	0.5222	0.5222
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Brugia malayi	fibroinase precursor	0.0108	0.1135	0.1135
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0725	0.7958	0.7958
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0108	0.1135	0.217
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.1135	0.1135
Brugia malayi	Cathepsin L-like precursor	0.0328	0.3565	0.3565
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1135	0.1135
Entamoeba histolytica	calpain family cysteine protease, putative	0.0006	0.0002	0.0004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.091	1	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0055	0.055	0.055
Onchocerca volvulus		0.0478	0.5222	1
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0035	0.0035
Trypanosoma brucei	kinesin, putative	0.0014	0.0091	0.0169
Brugia malayi	calpain 5	0.0006	0.0002	0.0002
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.5222	0.5222
Brugia malayi	calpain 5	0.0014	0.0091	0.0091
Plasmodium falciparum	serine repeat antigen 3	0.0108	0.1135	0.217
Loa Loa (eye worm)	SRC-1	0.001	0.0049	0.0049
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0356	0.3877	0.3875
Schistosoma mansoni	cathepsin s	0.015	0.1593	0.1593
Giardia lamblia	Cysteine protease	0.0108	0.1135	0.1898
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0258	0.2792	0.2792
Giardia lamblia	Cathepsin B precursor	0.0356	0.3877	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0258	0.2792	0.2792
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0035	0.0035
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.001	0.0049	0.0049
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0035	0.0035
Brugia malayi	Cathepsin L-like precursor	0.0328	0.3565	0.3565
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0493	0.049
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1135	0.1135
Giardia lamblia	Cathepsin B precursor	0.0356	0.3877	1
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.1135	0.1135
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.001	0.0049	0.0049
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0049	0.0049
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0523	0.0523
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0108	0.1135	0.1135
Giardia lamblia	Cathepsin B precursor	0.0108	0.1135	0.1898
Brugia malayi	Papain family cysteine protease containing protein	0.0258	0.2792	0.2792
Leishmania major	cathepsin L-like protease	0.0478	0.5222	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0108	0.1135	0.193
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.5222	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.001	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.015	0.1593	0.1593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.001	0.0049	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.5222	1
Giardia lamblia	Cathepsin L precursor	0.0108	0.1135	0.1898
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0035	0.0035
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0049	0.0049
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0157	0.0297
Trypanosoma cruzi	cysteine proteinase, putative	0.0258	0.2792	0.279
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0049	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.0523	0.0523
Entamoeba histolytica	cysteine protease, putative	0.0258	0.2792	0.5346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0108	0.1135	0.217
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.002	0.0157	0.0297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0328	0.3565	0.6826
Toxoplasma gondii	cathepsin CPC1	0.0108	0.1135	0.217
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.091	1	1
Echinococcus granulosus	calpain A	0.002	0.0157	0.0157
Schistosoma mansoni	calpain (C02 family)	0.002	0.0157	0.0157
Giardia lamblia	Encystation-specific protease	0.0108	0.1135	0.1898
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1135	0.1135
Trypanosoma cruzi	cysteine protease, putative	0.0258	0.2792	0.279
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0035	0.0035
Brugia malayi	Cathepsin L-like precursor	0.0478	0.5222	0.5222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.5222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1135	0.217
Loa Loa (eye worm)	hypothetical protein	0.0478	0.5222	0.5222
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0493	0.0493
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0493	0.0939
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0157	0.0155

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.1 uM	Inhibitory activity against recombinant human p56 Lck tyrosine kinase	ChEMBL.	12139450
IC50 (binding)	= 5.1 uM	Inhibitory activity against recombinant human p56 Lck tyrosine kinase	ChEMBL.	12139450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10982890

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 311427