TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.798 | Formula: C17H21ClO6
H donors: 1 H acceptors: 3 LogP: 1.63 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cl[C@@H]1C[C@@]23C4(C1)[C@H](OC3=O)C[C@@](O2)([C@]14COC(=O)[C@@H]1O)C(C)(C)C
InChi: 1S/C17H21ClO6/c1-13(2,3)17-6-9-14(15(17)7-22-11(20)10(15)19)4-8(18)5-16(14,24-17)12(21)23-9/h8-10,19H,4-7H2,1-3H3/t8-,9+,10+,14?,15?,16+,17+/m0/s1
InChiKey: QKCLGIRKLWFDBF-DIHBFSTASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0137	0.0633	0.1302
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0635	0.4863	1
Onchocerca volvulus	Cathepsin F homolog	0.0635	0.4863	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0931	0.7382	1
Echinococcus multilocularis	cathepsin L	0.0137	0.0633	0.0847
Echinococcus multilocularis	cysteine protease	0.0635	0.4863	0.6583
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0087	0.0206	0.0267
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0633	0.0847
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0137	0.0633	0.0625
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.1182	0.136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0635	0.4863	0.6583
Trypanosoma cruzi	cruzipain precursor, putative	0.0827	0.6498	0.8767
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Brugia malayi	cathepsin F-like cysteine proteinase	0.0202	0.1182	0.1591
Trypanosoma cruzi	cysteine peptidase, putative	0.0827	0.6498	0.8767
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0137	0.0633	0.0847
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0383	0.2721	0.3997
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0137	0.0633	0.0847
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0635	0.4863	0.6583
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0137	0.0633	0.1302
Echinococcus granulosus	calpain 7 C02 family	0.0204	0.1201	0.1618
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1387
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Echinococcus multilocularis	cathepsin b	0.0931	0.7382	1
Echinococcus multilocularis	cathepsin b	0.0931	0.7382	1
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1583
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0772	0.6026	0.816
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Plasmodium vivax	serine-repeat antigen (SERA)	0.0137	0.0633	0.1302
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0633	0.0625
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0087	0.0206	0.0197
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0633	0.1302
Brugia malayi	fibroinase precursor	0.0137	0.0633	0.0847
Toxoplasma gondii	cathepsin CPC1	0.0137	0.0633	0.1302
Schistosoma mansoni	cathepsin F (C01 family)	0.0635	0.4863	0.4858
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0137	0.0633	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Echinococcus granulosus	cathepsin b	0.0931	0.7382	1
Echinococcus granulosus	cathepsin l1	0.0635	0.4863	0.6583
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Brugia malayi	Cathepsin L-like precursor	0.0202	0.1182	0.1591
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Plasmodium vivax	vivapain-2	0.0635	0.4863	1
Plasmodium falciparum	serine repeat antigen 4	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Echinococcus granulosus	cathepsin L	0.0137	0.0633	0.0847
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0137	0.0633	0.1302
Brugia malayi	calpain family protein 1	0.0541	0.4065	0.55
Echinococcus granulosus	cathepsin b	0.0931	0.7382	1
Echinococcus granulosus	calpain A	0.0204	0.1201	0.1618
Onchocerca volvulus		0.0635	0.4863	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0137	0.0633	0.0625
Schistosoma mansoni	cathepsin C	0.0137	0.0633	0.0625
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0137	0.0633	0.1302
Plasmodium vivax	unspecified product	0.0202	0.1182	0.2431
Plasmodium vivax	vivapain-3	0.0339	0.2348	0.4828
Leishmania major	cysteine peptidase A (CPA)	0.0635	0.4863	0.7402
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0339	0.2348	0.2985
Schistosoma mansoni	calpain (C02 family)	0.0204	0.1201	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Mycobacterium leprae	conserved hypothetical protein	0.0063	0	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0633	0.0847
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1387
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0206	0.0267
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0137	0.0633	0.1302
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0433	0.3148	0.4258
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.2348	0.2341
Echinococcus multilocularis	calpain	0.0204	0.1201	0.1618
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Schistosoma mansoni	calpain-7 (C02 family)	0.0204	0.1201	0.1194
Echinococcus granulosus	calpain 5	0.0204	0.1201	0.1618
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1583
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0633	0.0625
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0772	0.6026	0.816
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0143	0.068	0.0111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0383	0.2721	0.3504
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0383	0.2721	0.2714
Brugia malayi	Papain family cysteine protease containing protein	0.0339	0.2348	0.3172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0137	0.0633	0.1302
Plasmodium falciparum	serine repeat antigen 3	0.0137	0.0633	0.1302
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0541	0.4065	0.55
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0635	0.4863	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1583
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0137	0.0633	0.0625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2348	0.3405
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0137	0.0633	0.1302
Onchocerca volvulus		0.0337	0.233	0.4783
Schistosoma mansoni	cathepsin D (A01 family)	0.0146	0.0709	0.0701
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Echinococcus multilocularis	calpain family protein 1, d	0.0398	0.2852	0.3856
Plasmodium falciparum	serine repeat antigen 9	0.0137	0.0633	0.1302
Onchocerca volvulus	Cathepsin L homolog	0.0635	0.4863	1
Entamoeba histolytica	cysteine proteinase 2	0.0339	0.2348	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0433	0.3148	0.4258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0582	0.4415	0.5975
Trypanosoma brucei	calpain-like protein, putative	0.0204	0.1201	0.1583
Echinococcus multilocularis	cathepsin L	0.0339	0.2348	0.3172
Echinococcus multilocularis	calpain A	0.0583	0.4425	0.5989
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.2348	0.2985
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0383	0.2721	0.5594
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.0633	0.0847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Mycobacterium ulcerans	putative regulatory protein	0.0063	0	0.5
Loa Loa (eye worm)	calpain family protein 1	0.0541	0.4065	0.55
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0137	0.0633	0.1302
Loa Loa (eye worm)	calpain	0.0204	0.1201	0.1618
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.0633	0.1286
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1387
Brugia malayi	Papain family cysteine protease containing protein	0.0635	0.4863	0.6583
Loa Loa (eye worm)	hypothetical protein	0.0479	0.3543	0.4793
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1387
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Mycobacterium ulcerans	putative regulatory protein	0.0063	0	0.5
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0063	0	0.5
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0137	0.0633	0.1302
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0931	0.7382	0.738
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2348	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0339	0.2348	0.2985
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0635	0.4863	1
Leishmania major	kinesin, putative	0.0143	0.068	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0635	0.4863	0.6583
Entamoeba histolytica	protein kinase, putative	0.0143	0.068	0.0111
Giardia lamblia	Cathepsin B precursor	0.0383	0.2721	1
Onchocerca volvulus		0.0635	0.4863	1
Loa Loa (eye worm)	hypothetical protein	0.0747	0.582	0.7881
Brugia malayi	calpain family protein 1	0.0541	0.4065	0.55
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1387
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0633	0.1302
Brugia malayi	calpain 5	0.0143	0.068	0.0911
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0137	0.0633	0.1302
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Onchocerca volvulus		0.0635	0.4863	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0827	0.6498	0.8767
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2348	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Entamoeba histolytica	cysteine protease, putative	0.0635	0.4863	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0339	0.2348	0.4828
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1387
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2348	0.4054
Toxoplasma gondii	cathepsin CPL	0.0635	0.4863	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0633	0.0625
Brugia malayi	calpain 7	0.0204	0.1201	0.1618
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0383	0.2721	0.3997
Giardia lamblia	Cathepsin B precursor	0.0383	0.2721	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0931	0.7382	0.738
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trypanosoma brucei	calpain-like protein, putative	0.0204	0.1201	0.1583
Schistosoma mansoni	calpain C (C02 family)	0.0204	0.1201	0.1194
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0633	0.1302
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0931	0.7382	0.738
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0204	0.1201	0.1194
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.0633	0.0847
Onchocerca volvulus		0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Brugia malayi	cathepsin L-like precursor	0.0433	0.3148	0.4258
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0635	0.4863	0.6583
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1182	0.1591
Echinococcus granulosus	cathepsin l1	0.0433	0.3148	0.4258
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0635	0.4863	0.6583
Plasmodium falciparum	serine repeat antigen 1	0.0137	0.0633	0.1302
Echinococcus granulosus	cathepsin L	0.0339	0.2348	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0685	0.5287	0.7159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0339	0.2348	0.3172
Toxoplasma gondii	cathepsin B	0.0383	0.2721	0.5594
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Brugia malayi	Papain family cysteine protease containing protein	0.0339	0.2348	0.3172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Plasmodium vivax	unspecified product	0.0339	0.2348	0.4828
Echinococcus multilocularis	cathepsin L cysteine protease	0.0635	0.4863	0.6583
Giardia lamblia	Cathepsin B precursor	0.0383	0.2721	1
Onchocerca volvulus		0.0137	0.0633	0.1286
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0635	0.4863	0.6583
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0206	0.0423
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0206	0.0267
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0206	0.0423
Leishmania major	cathepsin L-like protease	0.0635	0.4863	0.7402
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1387
Leishmania major	cathepsin L-like protease	0.0827	0.6498	1
Echinococcus multilocularis	calpain 5	0.0204	0.1201	0.1618
Leishmania major	cathepsin L-like protease	0.0827	0.6498	1
Brugia malayi	cathepsin L precursor	0.0137	0.0633	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0398	0.2852	0.3856
Trypanosoma cruzi	cysteine proteinase, putative	0.0339	0.2348	0.2985
Schistosoma mansoni	cathepsin S (C01 family)	0.0137	0.0633	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0137	0.0633	0.0847
Trypanosoma cruzi	cysteine peptidase, putative	0.0635	0.4863	0.6489
Toxoplasma gondii	cathepsin CPC2	0.0137	0.0633	0.1302
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0137	0.0633	0.1302
Plasmodium falciparum	serine repeat antigen 2	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0633	0.1302
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0137	0.0633	0.1302
Entamoeba histolytica	cysteine proteinase, putative	0.0433	0.3148	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3148	0.4258
Plasmodium vivax	vivapain-2	0.0635	0.4863	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2348	0.3405
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0137	0.0633	0.0625
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1387
Leishmania major	cathepsin L-like protease	0.0635	0.4863	0.7402
Onchocerca volvulus		0.0433	0.3148	0.6467
Trypanosoma brucei	calpain-like protein, putative	0.0204	0.1201	0.1583
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Trypanosoma cruzi	major cysteine proteinase, putative	0.0329	0.2268	0.2874
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Loa Loa (eye worm)	calpain 5	0.0143	0.068	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0931	0.7382	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0206	0.0423
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0137	0.0633	0.1302
Entamoeba histolytica	cysteine proteinase 1, putative	0.0339	0.2348	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0137	0.0633	0.1302
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0582	0.4415	0.5975
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Echinococcus multilocularis	cysteine protease	0.0635	0.4863	0.6583
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0772	0.6026	0.816
Leishmania major	cathepsin L-like protease	0.0635	0.4863	0.7402
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0633	0.1302
Schistosoma mansoni	cathepsin F (C01 family)	0.0635	0.4863	0.4858
Echinococcus multilocularis	hypothetical protein	0.0204	0.1201	0.1618
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3148	0.6474
Trypanosoma cruzi	cysteine protease, putative	0.0339	0.2348	0.2985
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0633	0.1302
Echinococcus multilocularis	calpain 7 (C02 family)	0.0204	0.1201	0.1618
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0204	0.1201	0.1583
Schistosoma mansoni	calpain-7 (C02 family)	0.0204	0.1201	0.1194
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0063	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.3148	0.4258
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1583
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.2348	0.2341
Onchocerca volvulus		0.0635	0.4863	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2348	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0635	0.4863	1
Leishmania major	cathepsin L-like protease	0.0827	0.6498	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0433	0.3148	0.3142
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0633	0.1302
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0204	0.1201	0.1387
Echinococcus granulosus	calpain	0.0204	0.1201	0.1618
Leishmania major	cathepsin L-like protease	0.0635	0.4863	0.7402
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Entamoeba histolytica	cysteine proteinase, putative	0.0635	0.4863	1
Echinococcus granulosus	cysteine protease	0.0339	0.2348	0.3172
Onchocerca volvulus	Cathepsin L homolog	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0633	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1182	0.1591
Plasmodium falciparum	serine repeat antigen 8	0.0137	0.0633	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0433	0.3148	0.4258
Loa Loa (eye worm)	fibroinase	0.0635	0.4863	0.6583
Trypanosoma cruzi	cysteine peptidase, putative	0.0827	0.6498	0.8767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Echinococcus granulosus	calpain A	0.0583	0.4425	0.5989
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0225	0.1382	0.1375
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trypanosoma brucei	antigen, putative	0.0204	0.1201	0.1583
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Loa Loa (eye worm)	calpain family protein 1	0.0398	0.2852	0.3856
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0541	0.4065	0.4059
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.2348	0.2341
Onchocerca volvulus		0.0635	0.4863	1
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Plasmodium vivax	serine-repeat antigen (SERA)	0.0137	0.0633	0.1302
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Schistosoma mansoni	cathepsin D (A01 family)	0.0146	0.0709	0.0701
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0635	0.4863	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0582	0.4415	0.441
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0137	0.0633	0.1302
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Plasmodium falciparum	serine repeat antigen 5	0.0137	0.0633	0.1302
Loa Loa (eye worm)	cysteine protease	0.0635	0.4863	0.6583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Loa Loa (eye worm)	ctsf protein	0.0635	0.4863	0.6583
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0137	0.0633	0.0847
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0582	0.4415	0.441
Loa Loa (eye worm)	cathepsin B	0.0383	0.2721	0.3678
Trypanosoma cruzi	kinesin, putative	0.0143	0.068	0.0661
Brugia malayi	Cathepsin L-like precursor	0.0635	0.4863	0.6583
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0633	0.0625
Entamoeba histolytica	cysteine proteinase, putative	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Plasmodium vivax	vivapain-1	0.0339	0.2348	0.4828
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0625	0.4783	0.6378
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Trypanosoma cruzi	major cysteine proteinase, putative	0.0137	0.0633	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Plasmodium falciparum	serine repeat antigen 6	0.0137	0.0633	0.1302
Trypanosoma brucei	kinesin, putative	0.0143	0.068	0.0754
Onchocerca volvulus		0.0635	0.4863	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1182	0.1591
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0137	0.0633	0.0847
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0633	0.0847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0087	0.0206	0.0197
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0202	0.1182	0.136
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0931	0.7382	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2348	0.4828
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Schistosoma mansoni	cathepsin s	0.0202	0.1182	0.1174
Trypanosoma cruzi	kinesin, putative	0.0143	0.068	0.0661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0633	0.1302
Plasmodium falciparum	serine repeat antigen 7	0.0137	0.0633	0.1302
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3148	0.4258
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0202	0.1182	0.1591
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0137	0.0633	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0206	0.0267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0635	0.4863	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3148	0.6474
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0087	0.0206	0.0423
Trypanosoma brucei	calpain-like protein, putative	0.0204	0.1201	0.1583
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0063	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0202	0.1182	0.1591
Plasmodium vivax	calpain, putative	0.0204	0.1201	0.2471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0635	0.4863	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0931	0.7382	0.738
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0633	0.0847
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0137	0.0633	0.1302
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2348	0.4054
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0204	0.1201	0.1387
Echinococcus multilocularis	cathepsin L cysteine protease	0.0635	0.4863	0.6583
Plasmodium vivax	unspecified product	0.0137	0.0633	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0337	0.233	0.3149
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0633	0.0625
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0206	0.0423
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0635	0.4863	0.6583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Leishmania major	cathepsin L-like protease	0.0635	0.4863	0.7402
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0827	0.6498	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2348	0.4828

Activities

Activity type	Activity value	Assay description	Source	Reference
Binding affinity (binding)	= 1.1 uM	Binding affinity against platelet activating factor	ChEMBL.	9871752
Binding affinity (binding)	= 5.96 uM	Compound was evaluated for anti-platelet activating factor potency	ChEMBL.	9871752

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 131928

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 31178