Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Malate synthase G GlcB | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | Curated by TDR Targets | References |
Mycobacterium leprae | PROBABLE MALATE SYNTHASE G GLCB | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Isocitrate lyase | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 367 aa | 295 aa | 87.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0096 | 0 | 0.5 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2754 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.0033 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0096 | 0 | 0.5 |
Mycobacterium ulcerans | malate synthase G | 0.2754 | 1 | 1 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.1882 | 0.6721 | 0.5344 |
Brugia malayi | Matrixin family protein | 0.0105 | 0.0033 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0158 | 0.0232 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0158 | 0.0232 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 1.8 mM | Inhibitory activity of the compound against dihydrodipicolinic acid synthase was determined | ChEMBL. | 7241506 |
Ki (functional) | = 1.8 mM | Inhibitory activity of the compound against dihydrodipicolinic acid synthase was determined | ChEMBL. | 7241506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.