Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0313 | 0.195 | 0.195 |
Mycobacterium ulcerans | ATPase | 0.0793 | 0.5767 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1325 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1257 | 0.9457 | 0.9457 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0313 | 0.195 | 0.195 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0793 | 0.5767 | 0.5767 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1257 | 0.9457 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0793 | 0.5767 | 0.5767 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Giardia lamblia | AAA family ATPase | 0.0793 | 0.5767 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0548 | 0.3817 | 0.6768 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0249 | 0.0249 |
Brugia malayi | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1325 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0548 | 0.3817 | 0.3817 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0548 | 0.3817 | 0.6768 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 0.564 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1257 | 0.9457 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1325 | 1 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0793 | 0.5767 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Trypanosoma brucei | Valosin-containing protein | 0.1257 | 0.9457 | 1 |
Schistosoma mansoni | ATP-citrate synthase | 0.0394 | 0.2592 | 0.2592 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1257 | 0.9457 | 1 |
Loa Loa (eye worm) | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1325 | 1 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Toxoplasma gondii | ATP-citrate lyase, putative | 0.0439 | 0.2949 | 0.2949 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1325 | 1 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1257 | 0.9457 | 1 |
Brugia malayi | valosin containing protein | 0.0777 | 0.564 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.059 | 0.059 |
Brugia malayi | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0548 | 0.3817 | 0.3817 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 102 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (functional) | = 102 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (binding) | = 335 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
IC50 (binding) | = 335 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
Ki (binding) | = 9.55 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Ki (binding) | = 9.55 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.