Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0633 | 0.2895 | 0.2895 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.2895 | 0.2905 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.064 | 0.2931 | 0.4113 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0633 | 0.2895 | 0.2858 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.064 | 0.2931 | 0.4113 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0633 | 0.2895 | 0.2867 |
Schistosoma mansoni | vam6/vps39 related | 0.0633 | 0.2895 | 0.2867 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0066 | 0.0067 |
Onchocerca volvulus | 0.0633 | 0.2895 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.064 | 0.2931 | 0.4113 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.064 | 0.2931 | 0.2895 |
Schistosoma mansoni | protein kinase | 0.064 | 0.2931 | 0.2903 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.2895 | 0.2905 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.064 | 0.2931 | 0.2895 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.2139 | 0.9964 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.064 | 0.2931 | 0.2931 |
Schistosoma mansoni | protein kinase | 0.1514 | 0.7032 | 0.702 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0633 | 0.2895 | 0.5 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0633 | 0.2895 | 0.5 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0633 | 0.2895 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0633 | 0.2895 | 0.2867 |
Echinococcus granulosus | protein kinase | 0.1514 | 0.7032 | 0.7038 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.0865 | 0.0829 |
Schistosoma mansoni | protein kinase | 0.2147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2139 | 0.9964 | 1 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.1514 | 0.7032 | 0.7057 |
Brugia malayi | hypothetical protein | 0.0633 | 0.2895 | 0.2895 |
Echinococcus multilocularis | 0.1514 | 0.7032 | 1 | |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0633 | 0.2895 | 0.2867 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0633 | 0.2895 | 0.2867 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0633 | 0.2895 | 0.4061 |
Schistosoma mansoni | serine/threonine protein kinase | 0.064 | 0.2931 | 0.2903 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.064 | 0.2931 | 0.2895 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.2895 | 0.2905 |
Schistosoma mansoni | serine/threonine protein kinase | 0.064 | 0.2931 | 0.2903 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0633 | 0.2895 | 0.2858 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.064 | 0.2931 | 0.2942 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 uM | Inhibitory concentration against human calcium receptor expressed in HEK 293 cells | ChEMBL. | 15745796 |
IC50 (binding) | = 14 uM | Inhibitory concentration against human calcium receptor expressed in HEK 293 cells | ChEMBL. | 15745796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.