Detailed information for compound 318880

Basic information

Technical information
  • TDR Targets ID: 318880
  • Name: 4-(6-chlorohexyl)-7-nitro-1,3-dihydroquinoxal in-2-one
  • MW: 311.764 | Formula: C14H18ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 2.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCCCCCN1CC(=O)Nc2c1ccc(c2)[N+](=O)[O-]
  • InChi: 1S/C14H18ClN3O3/c15-7-3-1-2-4-8-17-10-14(19)16-12-9-11(18(20)21)5-6-13(12)17/h5-6,9H,1-4,7-8,10H2,(H,16,19)
  • InChiKey: WHHLNBLJXXDIBH-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.0727 0.2099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0492 0.2885
Schistosoma mansoni peptidase Clp (S14 family) 0.0558 0.2641 0.2641
Echinococcus granulosus Smad4 0.0056 0.0196 0.0196
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Onchocerca volvulus Cathepsin L homolog 0.0727 0.3465 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0025 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0228 0.1032 0.1535
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0147 0.0218
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0225 0.0225
Onchocerca volvulus 0.009 0.0361 0.0925
Echinococcus granulosus mothers against decapentaplegic 5 0.0056 0.0196 0.0196
Loa Loa (eye worm) glutathione reductase 0.0046 0.0147 0.0201
Onchocerca volvulus Cathepsin L homolog 0.0165 0.0727 0.1996
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.2981 0.4424
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0361 0.1041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Onchocerca volvulus 0.0048 0.0157 0.0328
Brugia malayi TAR-binding protein 0.0189 0.0845 0.1257
Brugia malayi MH2 domain containing protein 0.0056 0.0196 0.0291
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0192 0.0859 0.2479
Brugia malayi beta-lactamase 0.0035 0.0094 0.0139
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Giardia lamblia GTOR 0.0047 0.0153 0.0593
Giardia lamblia Cathepsin B precursor 0.0545 0.2581 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0361 0.0361
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Toxoplasma gondii hypothetical protein 0.0192 0.0859 0.2479
Schistosoma mansoni lamin 0.0057 0.0201 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0845 0.0845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Echinococcus multilocularis GPCR, family 2 0.0063 0.0228 0.0228
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.2355 0.6797
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0435 0.1338
Schistosoma mansoni smad 0.0056 0.0196 0.0196
Echinococcus multilocularis mothers against decapentaplegic 6 0.0025 0.0045 0.0045
Giardia lamblia Hypothetical protein 0.0165 0.0727 0.2817
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0147 0.0147
Plasmodium vivax serine-repeat antigen (SERA) 0.0165 0.0727 0.2099
Giardia lamblia Cathepsin L-like protease 0.0165 0.0727 0.2817
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0094 0.0549
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.0727 0.0727
Echinococcus granulosus tar DNA binding protein 0.0189 0.0845 0.0845
Onchocerca volvulus 0.0499 0.2355 0.6755
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0094 0.0122
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0366 0.1705 0.6323
Brugia malayi fibroinase precursor 0.0165 0.0727 0.1082
Giardia lamblia Cathepsin B precursor 0.0165 0.0727 0.2817
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0165 0.0727 0.1082
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0045 0.0049
Entamoeba histolytica hypothetical protein 0.0258 0.1178 0.3375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Echinococcus granulosus cathepsin b 0.1395 0.6723 0.6723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0393 0.1837 0.5302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0182 0.0271
Loa Loa (eye worm) fibroinase 0.0727 0.3465 0.5146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.2355 0.6797
Brugia malayi Cathepsin L-like cysteine proteinase 0.0499 0.2355 0.3503
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0094 0.027
Schistosoma mansoni smad1 5 8 and 0.0056 0.0196 0.0196
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0038
Mycobacterium ulcerans lipase LipD 0.0035 0.0094 0.0355
Echinococcus multilocularis mothers against decapentaplegic 5 0.0056 0.0196 0.0196
Entamoeba histolytica cysteine proteinase 2 0.0393 0.1837 0.5284
Onchocerca volvulus 0.0727 0.3465 1
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Trypanosoma cruzi cysteine peptidase, putative 0.0727 0.3465 0.5154
Plasmodium falciparum glutathione reductase 0.0046 0.0147 0.0424
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0558 0.2641 0.7623
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0165 0.0727 0.2099
Onchocerca volvulus Cathepsin F homolog 0.0727 0.3465 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0182 0.0526
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0106 0.0306
Plasmodium falciparum serine repeat antigen 6 0.0165 0.0727 0.2099
Toxoplasma gondii preprocathepsin c precursor, putative 0.0165 0.0727 0.2099
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0094 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0228 0.0339
Onchocerca volvulus 0.0057 0.0201 0.0456
Brugia malayi cathepsin F-like cysteine proteinase 0.0228 0.1032 0.1535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0153 0.0442
Echinococcus multilocularis zinc finger protein 0.002 0.0022 0.0022
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0165 0.0727 0.2068
Echinococcus multilocularis musashi 0.0057 0.0201 0.0201
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0013 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0013 0.0078
Onchocerca volvulus 0.0035 0.0094 0.0144
Mycobacterium ulcerans beta-lactamase 0.0035 0.0094 0.0355
Plasmodium falciparum serine repeat antigen 8 0.0165 0.0727 0.2099
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0558 0.2641 0.2641
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0153 0.0228
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Mycobacterium ulcerans bacterioferritin BfrA 0.0061 0.0219 0.0828
Schistosoma mansoni microtubule-associated protein tau 0.2067 1 1
Giardia lamblia Cathepsin B precursor 0.0165 0.0727 0.2817
Leishmania major GTP-binding protein, putative 0.0021 0.0025 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0727 0.3465 0.3465
Schistosoma mansoni cathepsin F (C01 family) 0.0499 0.2355 0.2355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Trypanosoma cruzi cruzipain precursor, putative 0.0727 0.3465 0.5154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1018 0.5972
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0106 0.0306
Giardia lamblia Cathepsin B precursor 0.0165 0.0727 0.2817
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0094 0.0094
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.0727 0.2099
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0094 0.0549
Trypanosoma cruzi cysteine peptidase, putative 0.0727 0.3465 0.5154
Onchocerca volvulus 0.0727 0.3465 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0056 0.0196 0.0274
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Plasmodium falciparum serine repeat antigen 5 0.0165 0.0727 0.2099
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1395 0.6723 0.6723
Schistosoma mansoni smad1 5 8 and 0.0056 0.0196 0.0196
Onchocerca volvulus 0.0727 0.3465 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0038
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0182 0.0526
Brugia malayi cathepsin Z-like cysteine proteinase 0.0165 0.0727 0.1082
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0094 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.0727 0.2099
Mycobacterium tuberculosis Conserved protein 0.0035 0.0094 0.0549
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0037 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.0889 0.1307
Plasmodium vivax vivapain-2 0.0727 0.3465 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0035 0.0102
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.0727 0.2817
Brugia malayi PHD-finger family protein 0.0026 0.0049 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.0727 0.2099
Brugia malayi Bromodomain containing protein 0.004 0.0117 0.0174
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Brugia malayi beta-lactamase family protein 0.0035 0.0094 0.0139
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0094 0.0549
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0035 0.0102
Mycobacterium tuberculosis Conserved protein 0.0035 0.0094 0.0549
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0243 0.1108 0.1634
Plasmodium falciparum serine repeat antigen 2 0.0165 0.0727 0.2099
Loa Loa (eye worm) TAR-binding protein 0.0189 0.0845 0.1242
Brugia malayi MH2 domain containing protein 0.0025 0.0045 0.0066
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0063 0.0228 0.0322
Schistosoma mansoni Smad4 0.0025 0.0045 0.0045
Echinococcus granulosus cathepsin L cysteine protease 0.0393 0.1837 0.1837
Echinococcus multilocularis expressed protein 0.0061 0.0219 0.0219
Schistosoma mansoni intermediate filament proteins 0.0057 0.0201 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0153 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0258 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.004 0.0117 0.0157
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0558 0.2641 0.2641
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0165 0.0727 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0393 0.1837 0.5284
Brugia malayi cathepsin Z-like cysteine proteinase 0.0165 0.0727 0.1082
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0094 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0094 0.0139
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0094 0.0139
Toxoplasma gondii cathepsin CPC2 0.0165 0.0727 0.2099
Echinococcus granulosus expressed protein 0.0061 0.0219 0.0219
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0009 0.0009
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0153 0.0442
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0027 0.0022
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Echinococcus granulosus importin subunit beta 1 0.0029 0.0062 0.0062
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1395 0.6723 0.6723
Schistosoma mansoni ferritin light chain 0.0061 0.0219 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0558 0.2641 0.7623
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0165 0.0727 0.2099
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0147 0.0201
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0499 0.2355 0.3492
Giardia lamblia Cysteine protease 0.0165 0.0727 0.2817
Schistosoma mansoni cellular tumor antigen P53 0.0243 0.1108 0.1108
Onchocerca volvulus 0.0243 0.1108 0.311
Brugia malayi MH2 domain containing protein 0.0056 0.0196 0.0291
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0147 0.0424
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0045 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0727 0.3465 0.5146
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0094 0.0122
Trypanosoma cruzi cruzipain precursor, putative 0.0228 0.1032 0.1535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0153 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0013
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0153 0.0405
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0094 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0147 0.0424
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0165 0.0727 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0059 0.017
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0393 0.1837 0.2733
Loa Loa (eye worm) MH2 domain-containing protein 0.0824 0.3941 0.5854
Loa Loa (eye worm) hypothetical protein 0.0228 0.1032 0.152
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0201 0.0298
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0182 0.0254
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Leishmania major cysteine peptidase A (CPA) 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.2355 0.3492
Giardia lamblia Cysteine protease 0.0165 0.0727 0.2817
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0094 0.0139
Schistosoma mansoni cathepsin F (C01 family) 0.0727 0.3465 0.3465
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0201 0.0281
Schistosoma mansoni ferritin 0.0061 0.0219 0.0219
Toxoplasma gondii cathepsin CPL 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0393 0.1837 0.5284
Onchocerca volvulus 0.0035 0.0094 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0108 0.0447 0.0447
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0165 0.0727 0.1066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.0889 0.1322
Giardia lamblia Hypothetical protein 0.0165 0.0727 0.2817
Schistosoma mansoni hypothetical protein 0.0063 0.0228 0.0228
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0106 0.0306
Echinococcus multilocularis cathepsin L cysteine protease 0.0727 0.3465 0.3465
Plasmodium vivax unspecified product 0.0165 0.0727 0.2099
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0192 0.0859 0.2479
Echinococcus granulosus smad 0.0056 0.0196 0.0196
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0165 0.0727 0.0727
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0013 0.005
Onchocerca volvulus 0.0727 0.3465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0153 0.0442
Echinococcus granulosus mothers against decapentaplegic 2 0.0025 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0499 0.2355 0.3503
Toxoplasma gondii cathepsin CPC1 0.0165 0.0727 0.2099
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0165 0.0727 0.2099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0165 0.0727 0.2099
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Brugia malayi Cathepsin L-like precursor 0.0228 0.1032 0.1535
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0071 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Trichomonas vaginalis ferritin, putative 0.0061 0.0219 0.0631
Plasmodium vivax unspecified product 0.0393 0.1837 0.5302
Trypanosoma cruzi cysteine peptidase, putative 0.0727 0.3465 0.5154
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Echinococcus granulosus cathepsin l1 0.0727 0.3465 0.3465
Schistosoma mansoni cathepsin B (C01 family) 0.0165 0.0727 0.0727
Brugia malayi Papain family cysteine protease containing protein 0.0727 0.3465 0.5154
Loa Loa (eye worm) hypothetical protein 0.0228 0.1032 0.152
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Loa Loa (eye worm) hypothetical protein 0.0236 0.1072 0.158
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.0845 0.1242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0228 0.0322
Echinococcus granulosus tumor protein p63 0.1662 0.8025 0.8025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Echinococcus granulosus cysteine protease 0.0393 0.1837 0.1837
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0727 0.2099
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1072 0.1072
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0492 0.2885
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0435 0.2549
Echinococcus granulosus GPCR family 2 0.0063 0.0228 0.0228
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0545 0.2581 0.745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0447 0.0649
Mycobacterium ulcerans bacterioferritin BfrB 0.0061 0.0219 0.0828
Trypanosoma brucei trypanothione reductase 0.0046 0.0147 0.0424
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0077 0.0222
Echinococcus granulosus snurportin 1 0.0306 0.1413 0.1413
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 0.7623
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0057 0.0057
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0106 0.0158
Entamoeba histolytica cysteine proteinase, putative 0.0393 0.1837 0.5284
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0228 0.0228
Echinococcus granulosus TGF beta signal transducer SmadC 0.0056 0.0196 0.0196
Trypanosoma brucei cysteine peptidase C (CPC) 0.0545 0.2581 0.745
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0094 0.0549
Schistosoma mansoni bromodomain containing protein 0.0066 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0558 0.2641 0.3918
Brugia malayi Papain family cysteine protease containing protein 0.0393 0.1837 0.2733
Brugia malayi cathepsin L-like precursor 0.0499 0.2355 0.3503
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0165 0.0727 0.2099
Brugia malayi intermediate filament protein 0.0057 0.0201 0.0298
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0106 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0165 0.0727 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0106 0.0306
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.0727 0.0727
Echinococcus multilocularis lamin 0.0057 0.0201 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0182 0.0526
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0094 0.027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0072
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0228 0.0339
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.0727 0.0727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Brugia malayi Pre-SET motif family protein 0.009 0.0361 0.0537
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0182 0.0271
Schistosoma mansoni Smad4 0.0025 0.0045 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0228 0.1032 0.152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0106 0.0306
Trypanosoma brucei protein kinase, putative 0.0053 0.0182 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0727 0.3465 0.5154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0281 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0165 0.0727 0.2099
Brugia malayi Pre-SET motif family protein 0.0627 0.2981 0.4434
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0165 0.0727 0.2099
Plasmodium falciparum serine repeat antigen 3 0.0165 0.0727 0.2099
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0393 0.1837 0.1837
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.0727 0.1082
Schistosoma mansoni importin beta-1 0.0029 0.0062 0.0062
Plasmodium falciparum serine repeat antigen 4 0.0165 0.0727 0.2099
Plasmodium falciparum importin beta, putative 0.0029 0.0062 0.0178
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1395 0.6723 1
Trypanosoma cruzi cysteine proteinase, putative 0.0393 0.1837 0.2733
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0182 0.0526
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0201 0.0281
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0062 0.0178
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0025 0.0072
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0366 0.1705 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Schistosoma mansoni cathepsin S (C01 family) 0.0165 0.0727 0.0727
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0727 0.3465 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0108 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0306 0.1413 0.1413
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0165 0.0727 0.2817
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0832 0.3981 0.3981
Schistosoma mansoni hypothetical protein 0.0258 0.1178 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0545 0.2581 0.745
Echinococcus multilocularis peptidase Clp (S14 family) 0.0366 0.1705 0.1705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0393 0.1837 0.5302
Schistosoma mansoni survival motor neuron protein 0.0048 0.0157 0.0157
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0031 0.0091
Giardia lamblia Cathepsin L precursor 0.0165 0.0727 0.2817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0492 0.1563
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0727 0.3465 1
Schistosoma mansoni ran 0.0021 0.0025 0.0025
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0061 0.0219 0.1284
Schistosoma mansoni hypothetical protein 0.0063 0.0228 0.0228
Echinococcus granulosus cathepsin L 0.0393 0.1837 0.1837
Giardia lamblia Cathepsin B precursor 0.0545 0.2581 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0056 0.0196 0.0196
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0727 0.3465 0.3465
Echinococcus multilocularis ferritin 0.0061 0.0219 0.0219
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Schistosoma mansoni ran 0.0021 0.0025 0.0025
Onchocerca volvulus 0.0165 0.0727 0.1996
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0435 0.2549
Giardia lamblia Cathepsin B precursor 0.0165 0.0727 0.2817
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0072 0.0208
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0139 0.0189
Onchocerca volvulus 0.0727 0.3465 1
Giardia lamblia Cysteine protease 0.0165 0.0727 0.2817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Schistosoma mansoni hypothetical protein 0.0063 0.0228 0.0228
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0094 0.0549
Loa Loa (eye worm) cysteine protease 0.0727 0.3465 0.5146
Plasmodium vivax serine-repeat antigen (SERA) 0.0165 0.0727 0.2099
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0182 0.0182
Echinococcus multilocularis lamin dm0 0.0057 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0499 0.2355 0.3492
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0182 0.0271
Entamoeba histolytica hypothetical protein 0.0258 0.1178 0.3375
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0153 0.0442
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0558 0.2641 0.7623
Echinococcus multilocularis cathepsin b 0.1395 0.6723 0.6723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.0727 0.1082
Entamoeba histolytica hypothetical protein 0.0258 0.1178 0.3375
Schistosoma mansoni ferritin light chain 0.0061 0.0219 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0182 0.0182
Echinococcus multilocularis smad 0.0056 0.0196 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0727 0.3465 1
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0094 0.0355
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0038
Brugia malayi MH1 domain containing protein 0.0031 0.0074 0.0109
Echinococcus multilocularis cathepsin b 0.1395 0.6723 0.6723
Giardia lamblia Cathepsin B precursor 0.0545 0.2581 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0366 0.1705 1
Plasmodium vivax unspecified product 0.0228 0.1032 0.2979
Echinococcus multilocularis cysteine protease 0.0727 0.3465 0.3465
Giardia lamblia Cysteine protease 0.0165 0.0727 0.2817
Schistosoma mansoni hypothetical protein 0.0048 0.0157 0.0157
Toxoplasma gondii ABC1 family protein 0.0035 0.0094 0.027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0037
Schistosoma mansoni cathepsin s 0.0228 0.1032 0.1032
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0051
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0727 0.3465 0.5146
Echinococcus granulosus cathepsin l1 0.0499 0.2355 0.2355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0225 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0845 0.0845
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0845 0.0845
Brugia malayi MH1 domain containing protein 0.0031 0.0074 0.0109
Plasmodium vivax importin-beta 2, putative 0.0029 0.0062 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0228 0.0228
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Plasmodium vivax vivapain-1 0.0393 0.1837 0.5302
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0094 0.0094
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0013 0.002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0108 0.0447 0.0447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Brugia malayi beta-lactamase family protein 0.0035 0.0094 0.0139
Loa Loa (eye worm) cathepsin B 0.0545 0.2581 0.3829
Onchocerca volvulus Cathepsin L homolog 0.0727 0.3465 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0182 0.0526
Brugia malayi hypothetical protein 0.0258 0.1178 0.1753
Loa Loa (eye worm) hypothetical protein 0.1395 0.6723 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0059 0.017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0049
Schistosoma mansoni smad1 5 8 and 0.0056 0.0196 0.0196
Leishmania major trypanothione reductase 0.0046 0.0147 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0064
Schistosoma mansoni ferritin 0.0061 0.0219 0.0219
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0061 0.0219 0.1284
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0165 0.0727 0.2099
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0182 0.0182
Entamoeba histolytica cysteine proteinase, putative 0.0727 0.3465 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0198 0.0889 0.1307
Echinococcus granulosus intermediate filament protein 0.0057 0.0201 0.0201
Loa Loa (eye worm) ctsf protein 0.0727 0.3465 0.5146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0038
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0165 0.0727 0.2099
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0182 0.0526
Brugia malayi cathepsin B-like cysteine proteinase 0.1395 0.6723 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Brugia malayi Papain family cysteine protease containing protein 0.0165 0.0727 0.1082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0727 0.3465 0.5146
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0105 0.0105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0361 0.0361
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0345 0.0345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0153 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0165 0.0727 0.2099
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1413 0.2088
Echinococcus granulosus cathepsin b 0.1395 0.6723 0.6723
Brugia malayi RNA, U transporter 1 0.0081 0.0319 0.0475
Echinococcus multilocularis Smad4 0.0056 0.0196 0.0196
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0165 0.0727 0.2099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.0727 0.2099
Plasmodium falciparum serine repeat antigen 9 0.0165 0.0727 0.2099
Entamoeba histolytica cysteine protease, putative 0.0727 0.3465 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0182 0.0271
Loa Loa (eye worm) hypothetical protein 0.0165 0.0727 0.1066
Brugia malayi Thioredoxin reductase 0.0046 0.0147 0.0218
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0153 0.0228
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1395 0.6723 0.6723
Trypanosoma cruzi cysteine protease, putative 0.0393 0.1837 0.2733
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0165 0.0727 0.2099
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0228 0.1032 0.1535
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0258 0.1178 0.1178
Loa Loa (eye worm) nuclear factor I 0.0031 0.0074 0.0092
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0165 0.0727 0.2099
Brugia malayi glutathione reductase 0.0046 0.0147 0.0218
Loa Loa (eye worm) hypothetical protein 0.0136 0.0583 0.0851
Entamoeba histolytica hypothetical protein 0.0165 0.0727 0.2068
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0153 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Echinococcus multilocularis microtubule associated protein 2 0.2067 1 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0035 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.0889 0.1322
Treponema pallidum bacterioferrin (TpF1) 0.0061 0.0219 0.0828
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Schistosoma mansoni lamin 0.0057 0.0201 0.0201
Echinococcus granulosus zinc finger protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0074
Schistosoma mansoni smad 0.0025 0.0045 0.0045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0147 0.0861
Brugia malayi Bromodomain containing protein 0.0078 0.0303 0.0451
Entamoeba histolytica Ran family GTPase 0.0021 0.0025 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0165 0.0727 0.1066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.0727 0.0727
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0094 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0106 0.0306
Onchocerca volvulus 0.0727 0.3465 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0393 0.1837 0.5302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0393 0.1837 0.5302
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Entamoeba histolytica hypothetical protein 0.0258 0.1178 0.3375
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0094 0.0549
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0025 0.0072
Giardia lamblia Encystation-specific protease 0.0165 0.0727 0.2817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0545 0.2581 0.2581
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Echinococcus multilocularis snurportin 1 0.0306 0.1413 0.1413
Schistosoma mansoni apoferritin-2 0.0061 0.0219 0.0219
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.0845 0.1257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0071 0.0106
Trypanosoma cruzi major cysteine proteinase, putative 0.0165 0.0727 0.1082
Plasmodium falciparum serine repeat antigen 7 0.0165 0.0727 0.2099
Mycobacterium tuberculosis Conserved protein 0.0035 0.0094 0.0549
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0165 0.0727 0.2099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Brugia malayi cathepsin L precursor 0.0165 0.0727 0.1082
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0192 0.0859 0.3252
Schistosoma mansoni hypothetical protein 0.0021 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0094 0.027
Echinococcus granulosus cathepsin L 0.0165 0.0727 0.0727
Schistosoma mansoni apoferritin-2 0.0061 0.0219 0.0219
Trichomonas vaginalis set domain proteins, putative 0.0714 0.3403 0.9822
Echinococcus multilocularis cysteine protease 0.0727 0.3465 0.3465
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0393 0.1837 0.1837
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0094 0.027
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0545 0.2581 0.384
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0165 0.0727 0.2099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0258 0.1178 0.1178
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0492 0.2885
Echinococcus granulosus ferritin 0.0061 0.0219 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0153 0.0442
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0119 0.0344
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0094 0.0355
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.0727 0.2817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Brugia malayi cathepsin F-like cysteine proteinase 0.0165 0.0727 0.1082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0122
Echinococcus granulosus mothers against decapentaplegic 6 0.0025 0.0045 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0094 0.0094
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0182 0.0182
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0845 0.0845
Onchocerca volvulus 0.0714 0.3403 0.9819
Brugia malayi Cathepsin L-like precursor 0.0727 0.3465 0.5154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Entamoeba histolytica cysteine protease, putative 0.0165 0.0727 0.2068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0002
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0061 0.0219 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Brugia malayi Cathepsin L-like precursor 0.0499 0.2355 0.3503
Mycobacterium tuberculosis Probable reductase 0.0105 0.0435 0.2549
Onchocerca volvulus 0.0727 0.3465 1
Schistosoma mansoni cathepsin F (C01 family) 0.0727 0.3465 0.3465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0165 0.0727 0.2099
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0062 0.0178
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Plasmodium falciparum serine repeat antigen 1 0.0165 0.0727 0.2099
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0165 0.0727 0.0727
Schistosoma mansoni hypothetical protein 0.0136 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0042 0.0129 0.0175
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0165 0.0727 0.0727
Brugia malayi hypothetical protein 0.0236 0.1072 0.1595
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0558 0.2641 1
Schistosoma mansoni Smad4 0.0056 0.0196 0.0196
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0182 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0393 0.1837 0.5284
Echinococcus granulosus histone lysine methyltransferase setb 0.0108 0.0447 0.0447
Onchocerca volvulus 0.0057 0.0201 0.0456
Echinococcus granulosus lamin dm0 0.0057 0.0201 0.0201
Echinococcus multilocularis tumor protein p63 0.1662 0.8025 0.8025
Brugia malayi RNA binding protein 0.0189 0.0845 0.1257
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0037 0.0037
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0192 0.0859 0.3004
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0061 0.0219 0.0828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0174
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0182 0.0706
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0157 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Leishmania major hypothetical protein, conserved 0.0035 0.0094 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0727 0.2099
Echinococcus granulosus cathepsin l cysteine peptidase 0.0727 0.3465 0.3465
Echinococcus multilocularis tar DNA binding protein 0.0189 0.0845 0.0845
Schistosoma mansoni ferritin 0.0061 0.0219 0.0219
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0361 0.0361
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0105 0.0105
Schistosoma mansoni ferritin 0.0061 0.0219 0.0219
Brugia malayi mothers against decapentaplegic homolog 3 0.0025 0.0045 0.0066
Plasmodium vivax vivapain-3 0.0393 0.1837 0.5302
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0165 0.0727 0.2817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0393 0.1837 0.5302
Loa Loa (eye worm) hypothetical protein 0.0228 0.1032 0.152
Entamoeba histolytica cysteine proteinase, putative 0.0393 0.1837 0.5284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Brugia malayi Importin beta-1 subunit 0.0029 0.0062 0.0092
Schistosoma mansoni zinc finger protein 0.002 0.0022 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0056 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0063 0.0228 0.0228
Trypanosoma cruzi cysteine proteinase, putative 0.0393 0.1837 0.2733
Echinococcus granulosus cathepsin L cysteine proteinase 0.0727 0.3465 0.3465
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Toxoplasma gondii cathepsin B 0.0545 0.2581 0.745
Brugia malayi Smad1 0.0056 0.0196 0.0291
Brugia malayi MH2 domain containing protein 0.0824 0.3941 0.5862
Loa Loa (eye worm) transcription factor SMAD2 0.0824 0.3941 0.5854
Trypanosoma cruzi major cysteine proteinase, putative 0.0165 0.0727 0.1082
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0165 0.0727 0.0727
Trichomonas vaginalis ran, putative 0.0021 0.0025 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0094 0.0271
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0009 0.0009
Plasmodium vivax vivapain-2 0.0727 0.3465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0165 0.0727 0.2099
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0165 0.0727 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0153 0.0442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0165 0.0727 0.0727
Loa Loa (eye worm) MH1 domain-containing protein 0.0056 0.0196 0.0274
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.2355 0.6784
Echinococcus multilocularis cathepsin L 0.0393 0.1837 0.1837
Loa Loa (eye worm) RNA binding protein 0.0189 0.0845 0.1242
Loa Loa (eye worm) Smad1 0.0056 0.0196 0.0274
Trichomonas vaginalis esterase, putative 0.0035 0.0094 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0727 0.3465 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.0393 0.1837 0.2733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0281
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0435 0.2549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Plasmodium falciparum thioredoxin reductase 0.0046 0.0147 0.0424
Giardia lamblia Cathepsin L-like protease 0.0165 0.0727 0.2817
Giardia lamblia Cathepsin B precursor 0.0165 0.0727 0.2817
Plasmodium falciparum cysteine proteinase falcipain 3 0.0727 0.3465 1
Echinococcus multilocularis cathepsin L 0.0165 0.0727 0.0727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0165 0.0727 0.1082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0727 0.3465 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0558 0.2641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0727 0.3465 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0499 0.2355 0.3503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0165 0.0727 0.2099
Schistosoma mansoni cathepsin C 0.0165 0.0727 0.0727
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0182 0.0182
Plasmodium vivax SET domain protein, putative 0.009 0.0361 0.1041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0035 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0845 0.0845
Toxoplasma gondii exonuclease III APE 0.0019 0.0013 0.0038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0009 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0153 0.021
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 0.005
Onchocerca volvulus 0.0035 0.0094 0.0144
Brugia malayi MH1 domain containing protein 0.0056 0.0196 0.0291
Echinococcus multilocularis cathepsin L cysteine protease 0.0727 0.3465 0.3465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0047 0.0135
Brugia malayi MH1 domain containing protein 0.0056 0.0196 0.0291
Brugia malayi MAP kinase sur-1 0.0053 0.0182 0.0271
Brugia malayi Probable ClpP-like protease 0.0558 0.2641 0.3929
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0094 0.0549
Leishmania major cathepsin L-like protease 0.0727 0.3465 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0435 0.2549
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1395 0.6723 0.6723
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0182 0.0526
Entamoeba histolytica cysteine protease, putative 0.0393 0.1837 0.5284
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0583 0.0867
Echinococcus granulosus lamin 0.0057 0.0201 0.0201
Echinococcus granulosus peptidase Clp S14 family 0.0366 0.1705 0.1705
Entamoeba histolytica cysteine proteinase, putative 0.0727 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0196 0.0274
Toxoplasma gondii thioredoxin reductase 0.0046 0.0147 0.0424
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0435 0.2549
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0393 0.1837 0.1837
Brugia malayi Papain family cysteine protease containing protein 0.0393 0.1837 0.2733

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) 0 Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 16.6 % Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 16.6 % Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 23.2 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 23.2 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 32.9 % Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 32.9 % Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 72.1 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 72.1 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 90.9 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 90.9 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 97.4 % Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 97.4 % Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml ChEMBL. 16455249
Cytocidal activity (functional) = 99.15 % In vitro cytocidal activity of the compound against Trichomonas vaginalis at a dose of 100 ug/ml after 24 hours ChEMBL. 16005626
Cytocidal activity (functional) = 99.1500000000001 % In vitro cytocidal activity of the compound against Trichomonas vaginalis at a dose of 100 ug/ml after 24 hours ChEMBL. 16005626
Cytocidal activity (functional) = 99.83 % In vitro cytocidal activity of the compound against Trichomonas vaginalis at a dose of 100 ug/ml after 48 hours ChEMBL. 16005626
Cytocidal activity (functional) = 99.83 % In vitro cytocidal activity of the compound against Trichomonas vaginalis at a dose of 100 ug/ml after 48 hours ChEMBL. 16005626
Cytostatic activity (functional) = 0 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 1 ug/ml after 48 hours ChEMBL. 16005626
Cytostatic activity (functional) = 0 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 1 ug/ml after 48 hours ChEMBL. 16005626
Cytostatic activity (functional) = 8.76 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 1 ug/ml after 24 hours ChEMBL. 16005626
Cytostatic activity (functional) = 8.76 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 1 ug/ml after 24 hours ChEMBL. 16005626
Cytostatic activity (functional) = 30.56 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 10 ug/ml after 48 hours ChEMBL. 16005626
Cytostatic activity (functional) = 30.56 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 10 ug/ml after 48 hours ChEMBL. 16005626
Cytostatic activity (functional) = 79.28 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 10 ug/ml after 24 hours ChEMBL. 16005626
Cytostatic activity (functional) = 79.28 % In vitro cytostatic activity of the compound against Trichomonas vaginalis at a dose of 10 ug/ml after 24 hours ChEMBL. 16005626
GI (functional) = 73 % Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 10 ug/ml after 24 hrs by resazurin redox dye based fluorimetric microtiter method ChEMBL. 25771033

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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