Detailed information for compound 319008

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.837 | Formula: C18H20ClN5O
  • H donors: 1 H acceptors: 2 LogP: 3.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)nc([nH]2)N1CCN(C[C@H]1C)c1ncccc1Cl
  • InChi: 1S/C18H20ClN5O/c1-12-11-23(17-14(19)4-3-7-20-17)8-9-24(12)18-21-15-6-5-13(25-2)10-16(15)22-18/h3-7,10,12H,8-9,11H2,1-2H3,(H,21,22)/t12-/m1/s1
  • InChiKey: QMCSRFHZOUUSFJ-GFCCVEGCSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine repeat antigen 7 0.0132 0.0706 0.2283
Echinococcus granulosus cathepsin L 0.0299 0.1661 0.1661
Onchocerca volvulus 0.0545 0.3061 0.3054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0377 0.2106 0.2106
Echinococcus multilocularis cysteine protease 0.0545 0.3061 0.3061
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0034 0.0034
Plasmodium vivax vivapain-2 0.0545 0.3061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Trypanosoma brucei calpain-like protein, putative 0.002 0.0071 0.0067
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.3061 0.3061
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0067 0.0187
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0067 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0212 0.0212
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.0156
Brugia malayi cathepsin F-like cysteine proteinase 0.0167 0.0909 0.0909
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.3061 0.3361
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.0706 0.0767
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0282 0.1563 0.509
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0042
Plasmodium vivax vivapain-3 0.0299 0.1661 0.5411
Echinococcus granulosus cathepsin L cysteine proteinase 0.0545 0.3061 0.3061
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.4496 0.4496
Giardia lamblia Cathepsin B precursor 0.0515 0.2893 1
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0329 0.0329
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0545 0.3061 0.3061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Entamoeba histolytica protein kinase, putative 0.0014 0.0036 0.0086
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0132 0.0706 0.2283
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0695 0.3917 0.4305
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Schistosoma mansoni cathepsin s 0.0167 0.0909 0.0909
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0042
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0545 0.3061 0.3061
Plasmodium vivax unspecified product 0.0167 0.0909 0.2948
Echinococcus granulosus calpain 0.002 0.0071 0.0071
Giardia lamblia Cathepsin B precursor 0.0132 0.0706 0.2415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0071 0.0067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0105 0.0105
Trichomonas vaginalis ran, putative 0.0021 0.0072 0.0204
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0067
Toxoplasma gondii cathepsin CPC1 0.0132 0.0706 0.0767
Echinococcus granulosus cathepsin L 0.0132 0.0706 0.0706
Schistosoma mansoni cathepsin B (C01 family) 0.0132 0.0706 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.1563 0.509
Onchocerca volvulus 0.0545 0.3061 0.3054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0545 0.3061 1
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0706 0.0706
Brugia malayi prolyl oligopeptidase family protein 0.0282 0.1563 0.1563
Echinococcus granulosus acylamino acid releasing enzyme 0.0282 0.1563 0.1563
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0621 0.0621
Plasmodium vivax importin-beta 2, putative 0.0028 0.0114 0.0342
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1762 1 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0114 0.0114
Onchocerca volvulus 0.0377 0.2106 0.2098
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Loa Loa (eye worm) hypothetical protein 0.0377 0.2106 0.2106
Schistosoma mansoni DNA ligase IV 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Entamoeba histolytica hypothetical protein 0.0023 0.0084 0.0243
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0034 0.0034
Giardia lamblia Alanyl dipeptidyl peptidase 0.0282 0.1563 0.5386
Trypanosoma cruzi cysteine proteinase, putative 0.0299 0.1661 0.1819
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.0059 0.0291 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0212 0.0212
Schistosoma mansoni calpain C (C02 family) 0.002 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0212 0.0212
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0067 0.0063
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0706 0.2283
Brugia malayi Cathepsin L-like precursor 0.0377 0.2106 0.2106
Echinococcus multilocularis cathepsin L 0.0132 0.0706 0.0706
Entamoeba histolytica cysteine protease, putative 0.0545 0.3061 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0167 0.0909 0.0909
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0299 0.1661 0.1819
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0706 0.0706
Echinococcus granulosus lamin 0.0026 0.0105 0.0105
Giardia lamblia Cathepsin B precursor 0.0515 0.2893 1
Onchocerca volvulus 0.0545 0.3061 0.3054
Leishmania major importin beta-1 subunit, putative 0.0023 0.0084 0.0053
Echinococcus multilocularis cathepsin b 0.1372 0.7777 0.7777
Echinococcus multilocularis cathepsin b 0.1372 0.7777 0.7777
Brugia malayi Papain family cysteine protease containing protein 0.0299 0.1661 0.1661
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0034 0.0034
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0132 0.0706 0.2283
Toxoplasma gondii cathepsin CPC2 0.0132 0.0706 0.0767
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.002 0.0067 0.0187
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Plasmodium falciparum serine repeat antigen 8 0.0132 0.0706 0.2283
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0329 0.0329
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0695 0.3917 0.3917
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0706 0.0706
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Echinococcus multilocularis lamin dm0 0.0026 0.0105 0.0105
Onchocerca volvulus 0.0034 0.0146 0.0137
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Trypanosoma cruzi cruzipain precursor, putative 0.0545 0.3061 0.3361
Loa Loa (eye worm) hypothetical protein 0.1372 0.7777 0.7777
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0167 0.0909 0.0909
Brugia malayi intermediate filament protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0695 0.3917 0.4305
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.3061 0.3361
Trypanosoma cruzi oligopeptidase b 0.0714 0.4024 0.4422
Schistosoma mansoni P2X receptor subunit 0.0066 0.0329 0.0329
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0071 0.0071
Giardia lamblia Cathepsin B precursor 0.0132 0.0706 0.2415
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0706 0.2283
Loa Loa (eye worm) hypothetical protein 0.0413 0.2309 0.2309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Onchocerca volvulus 0.0026 0.0105 0.0095
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0114 0.0115
Plasmodium falciparum serine repeat antigen 3 0.0132 0.0706 0.2283
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Echinococcus granulosus cathepsin l1 0.0377 0.2106 0.2106
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0067 0.0187
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0329 0.0329
Schistosoma mansoni ran 0.0021 0.0072 0.0072
Schistosoma mansoni lamin 0.0026 0.0105 0.0105
Brugia malayi hypothetical protein 0.001 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0072 0.0204
Brugia malayi cathepsin L-like precursor 0.0377 0.2106 0.2106
Echinococcus granulosus cathepsin l cysteine peptidase 0.0545 0.3061 0.3061
Brugia malayi prolyl oligopeptidase family protein 0.1601 0.9087 0.9087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0042 0.0042
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0714 0.4024 0.4422
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0329 0.0329
Schistosoma mansoni P2X receptor subunit 0.0066 0.0329 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0132 0.0706 0.2283
Onchocerca volvulus Cathepsin F homolog 0.0545 0.3061 0.3054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0212 0.0212
Giardia lamblia Hypothetical protein 0.0132 0.0706 0.2415
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0243
Plasmodium vivax vivapain-2 0.0545 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Onchocerca volvulus 0.0545 0.3061 0.3054
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0706 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0276 0.0276
Schistosoma mansoni cathepsin C 0.0132 0.0706 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0156 0.0156
Onchocerca volvulus Cathepsin L homolog 0.0545 0.3061 0.3054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0299 0.1661 0.1661
Schistosoma mansoni calpain (C02 family) 0.002 0.0071 0.0071
Plasmodium falciparum serine repeat antigen 4 0.0132 0.0706 0.2283
Toxoplasma gondii prolyl endopeptidase 0.1601 0.9087 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.3061 0.3061
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.223 0.223
Echinococcus granulosus cathepsin L cysteine protease 0.0299 0.1661 0.1661
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0072 0.0072
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1319 0.7479 1
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0053 0.0053
Echinococcus multilocularis lamin 0.0026 0.0105 0.0105
Onchocerca volvulus 0.002 0.0067 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0212 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0299 0.1661 0.1819
Brugia malayi calpain 7 0.002 0.0071 0.0071
Brugia malayi calpain family protein 1 0.0054 0.0263 0.0263
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0072 0.0204
Plasmodium falciparum importin beta, putative 0.0028 0.0114 0.0342
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0714 0.4024 0.4406
Plasmodium vivax unspecified product 0.0132 0.0706 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0167 0.0909 0.0909
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0282 0.1563 0.509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0212 0.0212
Toxoplasma gondii cathepsin B 0.0515 0.2893 0.3176
Echinococcus multilocularis replication factor c subunit 1 0.001 0.001 0.001
Brugia malayi prolyl oligopeptidase family protein 0.0282 0.1563 0.1563
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0714 0.4024 0.4422
Echinococcus multilocularis prolyl endopeptidase 0.1601 0.9087 0.9087
Onchocerca volvulus Cathepsin L homolog 0.0545 0.3061 0.3054
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0706 0.2283
Trypanosoma cruzi hypothetical protein, conserved 0.0282 0.1563 0.1711
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.00000051037
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1601 0.9087 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Schistosoma mansoni ran 0.0021 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.004 0.0181 0.0181
Toxoplasma gondii ATPase, AAA family protein 0.001 0.001 0.00000017154
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0071 0.0071
Onchocerca volvulus 0.0026 0.0105 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.2106 0.6871
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0053 0.0053
Echinococcus granulosus calpain A 0.0056 0.0276 0.0276
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Trypanosoma brucei kinesin, putative 0.0014 0.0036 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.3061 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0714 0.4024 1
Brugia malayi RNA, U transporter 1 0.0079 0.0408 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0377 0.2106 0.2309
Plasmodium falciparum peptidase, putative 0.0282 0.1563 0.509
Plasmodium falciparum serine repeat antigen 1 0.0132 0.0706 0.2283
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0072 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Brugia malayi cathepsin B-like cysteine proteinase 0.1372 0.7777 0.7777
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0034 0.0034
Schistosoma mansoni importin beta-1 0.0028 0.0114 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0132 0.0706 0.2283
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0714 0.4024 0.4422
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0706 0.0706
Schistosoma mansoni hypothetical protein 0.0166 0.09 0.09
Trypanosoma brucei prolyl endopeptidase 0.1601 0.9087 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0105 0.0105
Echinococcus multilocularis cathepsin L 0.0299 0.1661 0.1661
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0273 0.0273
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.1601 0.9087 0.9087
Plasmodium falciparum cysteine proteinase falcipain 1 0.0299 0.1661 0.5411
Brugia malayi fibroinase precursor 0.0132 0.0706 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0706 0.2283
Plasmodium vivax calpain, putative 0.002 0.0071 0.02
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0072 0.0068
Trypanosoma cruzi oligopeptidase b 0.0714 0.4024 0.4422
Schistosoma mansoni cathepsin S (C01 family) 0.0132 0.0706 0.0706
Giardia lamblia Serine peptidase, putative 0.002 0.0067 0.0198
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0545 0.3061 0.3061
Trypanosoma brucei calpain-like protein, putative 0.002 0.0071 0.0067
Echinococcus granulosus prolyl endopeptidase 0.1601 0.9087 0.9087
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0706 0.2283
Brugia malayi Cathepsin L-like cysteine proteinase 0.0377 0.2106 0.2106
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0706 0.2283
Echinococcus granulosus cpg binding protein 0.0059 0.0291 0.0291
Echinococcus multilocularis calpain A 0.0056 0.0276 0.0276
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0706 0.2283
Trypanosoma cruzi hypothetical protein, conserved 0.0282 0.1563 0.1711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0067
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1762 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0027 0.0027
Onchocerca volvulus 0.0056 0.0273 0.0264
Giardia lamblia Cathepsin B precursor 0.0132 0.0706 0.2415
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0132 0.0706 0.0706
Chlamydia trachomatis DNA ligase 0.001 0.001 0.5
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Brugia malayi Importin beta-1 subunit 0.0028 0.0114 0.0114
Brugia malayi hypothetical protein 0.001 0.001 0.001
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0366 0.2043 0.2043
Onchocerca volvulus 0.0545 0.3061 0.3054
Loa Loa (eye worm) prolyl oligopeptidase 0.0282 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Plasmodium falciparum serine repeat antigen 2 0.0132 0.0706 0.2283
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0706 0.0706
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0299 0.1661 0.1819
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0042 0.0042
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0282 0.1563 0.1711
Trypanosoma cruzi cysteine proteinase, putative 0.0299 0.1661 0.1819
Loa Loa (eye worm) calpain family protein 1 0.004 0.0181 0.0181
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0132 0.0706 0.0706
Plasmodium falciparum serine repeat antigen 5 0.0132 0.0706 0.2283
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0132 0.0706 0.2283
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0071 0.0071
Echinococcus multilocularis geminin 0.0166 0.09 0.09
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Entamoeba histolytica cysteine proteinase, putative 0.0299 0.1661 0.5411
Trypanosoma cruzi cysteine protease, putative 0.0299 0.1661 0.1819
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.3061 0.3061
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Echinococcus granulosus cathepsin b 0.1372 0.7777 0.7777
Brugia malayi Papain family cysteine protease containing protein 0.0299 0.1661 0.1661
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0545 0.3061 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Brugia malayi Cathepsin L-like precursor 0.0377 0.2106 0.2106
Entamoeba histolytica prolyl oligopeptidase family protein 0.0282 0.1563 0.509
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0143 0.0143
Onchocerca volvulus Cathepsin L homolog 0.0132 0.0706 0.0697
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0042
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Echinococcus granulosus nibrin 0.001 0.001 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0706 0.2283
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Brugia malayi prolyl oligopeptidase family protein 0.0695 0.3917 0.3917
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0621 0.0621
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0042 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0377 0.2106 0.2106
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.3061 0.3061
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0366 0.2043 0.2043
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0114
Echinococcus granulosus cathepsin l1 0.0545 0.3061 0.3061
Brugia malayi hypothetical protein 0.0035 0.0156 0.0156
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Entamoeba histolytica calpain large subunit domain III containing protein 0.0014 0.0036 0.0086
Trypanosoma brucei cysteine peptidase C (CPC) 0.0515 0.2893 0.3176
Echinococcus granulosus replication factor c subunit 1 0.001 0.001 0.001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0515 0.2893 0.3176
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0706 0.0706
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0706 0.0706
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0067 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0282 0.1563 0.509
Giardia lamblia Cysteine protease 0.0132 0.0706 0.2415
Giardia lamblia Cathepsin B precursor 0.0132 0.0706 0.2415
Onchocerca volvulus 0.0132 0.0706 0.0697
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Echinococcus granulosus calpain 7 C02 family 0.002 0.0071 0.0071
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0263 0.0263
Toxoplasma gondii hypothetical protein 0.0282 0.1563 0.1711
Giardia lamblia Cathepsin B precursor 0.0132 0.0706 0.2415
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0706 0.2415
Giardia lamblia Cysteine protease 0.0132 0.0706 0.2415
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0084 0.0243
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0282 0.1563 0.1711
Plasmodium falciparum serine repeat antigen 9 0.0132 0.0706 0.2283
Giardia lamblia Encystation-specific protease 0.0132 0.0706 0.2415
Entamoeba histolytica prolyl oligopeptidase family protein 0.0282 0.1563 0.509
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0695 0.3917 0.4288
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Loa Loa (eye worm) hypothetical protein 0.0167 0.0909 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0132 0.0706 0.2283
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1762 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.023 0.023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1656 0.1656
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.001 0.00000051037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0299 0.1661 0.1661
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0156 0.0156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 0.7777 0.7777
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0706 0.0706
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1372 0.7777 0.8557
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0695 0.3917 0.4305
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.048
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Trypanosoma brucei prolyl oligopeptidase, putative 0.0714 0.4024 0.4422
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0545 0.3061 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0558 0.0604
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0695 0.3917 0.4305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0706 0.2415
Echinococcus multilocularis acylamino acid releasing enzyme 0.0282 0.1563 0.1563
Entamoeba histolytica cysteine proteinase 2 0.0299 0.1661 0.5411
Schistosoma mansoni P2X receptor subunit 0.0066 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0048 0.0228 0.0228
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0132 0.0706 0.2283
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0067 0.0067
Echinococcus granulosus dnaJ subfamily B 0.0399 0.223 0.223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0706 0.2283
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0114 0.0115
Schistosoma mansoni hypothetical protein 0.0033 0.0143 0.0143
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0072 0.0216
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0706 0.2283
Echinococcus granulosus calpain 5 0.002 0.0071 0.0071
Brugia malayi topoisomerase 0.001 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0299 0.1661 0.5411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Loa Loa (eye worm) fibroinase 0.0545 0.3061 0.3061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0706 0.0706
Brugia malayi hypothetical protein 0.0413 0.2309 0.2309
Entamoeba histolytica cysteine proteinase, putative 0.0299 0.1661 0.5411
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0276 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.3061 0.3361
Schistosoma mansoni intermediate filament proteins 0.0026 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) ctsf protein 0.0545 0.3061 0.3061
Schistosoma mansoni hypothetical protein 0.0399 0.223 0.223
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.023 0.023
Loa Loa (eye worm) prolyl oligopeptidase 0.1762 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0027
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0132 0.0706 0.2283
Entamoeba histolytica cysteine proteinase, putative 0.0377 0.2106 0.6871
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0706 0.0706
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0143
Entamoeba histolytica cysteine proteinase, putative 0.0299 0.1661 0.5411
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0282 0.1563 0.1563
Trypanosoma brucei calpain-like protein, putative 0.002 0.0071 0.0067
Schistosoma mansoni cpg binding protein 0.0059 0.0291 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Trypanosoma cruzi kinesin, putative 0.0014 0.0036 0.0029
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0132 0.0706 0.0706
Brugia malayi calpain family protein 1 0.0054 0.0263 0.0263
Schistosoma mansoni cpg binding protein 0.0056 0.0273 0.0273
Toxoplasma gondii preprocathepsin c precursor, putative 0.0132 0.0706 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0132 0.0706 0.2283
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Leishmania major GTP-binding protein, putative 0.0021 0.0072 0.004
Leishmania major oligopeptidase b 0.0714 0.4024 0.4406
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.3061 0.3061
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0067 0.0187
Entamoeba histolytica cysteine proteinase 1, putative 0.0299 0.1661 0.5411
Echinococcus multilocularis calpain 0.002 0.0071 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0299 0.1661 0.5411
Onchocerca volvulus 0.0545 0.3061 0.3054
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Trypanosoma cruzi prolyl endopeptidase 0.1601 0.9087 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.00000051037
Giardia lamblia Cathepsin L-like protease 0.0132 0.0706 0.2415
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0706 0.0706
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.3061 0.3361
Echinococcus granulosus cysteine protease 0.0299 0.1661 0.1661
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 0.7777 0.7777
Brugia malayi MH2 domain containing protein 0.0117 0.0621 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0299 0.1661 0.5411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0329 0.0329
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0053 0.0053
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0706 0.2283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Schistosoma mansoni cpg binding protein 0.0059 0.0291 0.0291
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.3061 0.3061
Schistosoma mansoni cathepsin F (C01 family) 0.0377 0.2106 0.2106
Brugia malayi calpain 5 0.0014 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0282 0.1563 0.1563
Echinococcus granulosus intermediate filament protein 0.0026 0.0105 0.0105
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0067 0.0067
Trypanosoma cruzi cruzipain precursor, putative 0.0167 0.0909 0.0991
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Giardia lamblia Cysteine protease 0.0132 0.0706 0.2415
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.063 0.063
Echinococcus multilocularis calpain 5 0.002 0.0071 0.0071
Echinococcus granulosus lamin dm0 0.0026 0.0105 0.0105
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0282 0.1563 0.1563
Schistosoma mansoni topbp1 0.001 0.001 0.001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0299 0.1661 0.1661
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0706 0.0706
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0706 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0067 0.0187
Brugia malayi cathepsin L-like cysteine proteinase 0.0132 0.0706 0.0706
Plasmodium vivax vivapain-1 0.0299 0.1661 0.5411
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0132 0.0706 0.2283
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0132 0.0706 0.2283
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.0706 0.0767
Echinococcus granulosus GPCR family 2 0.0015 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0515 0.2893 0.945
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.3061 1
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.0909 0.0991
Echinococcus granulosus importin subunit beta 1 0.0028 0.0114 0.0114
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0282 0.1563 0.509
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.3061 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0282 0.1563 0.1563
Trypanosoma cruzi cysteine peptidase, putative 0.0299 0.1661 0.1819
Schistosoma mansoni P2X receptor subunit 0.0066 0.0329 0.0329
Loa Loa (eye worm) cathepsin B 0.0515 0.2893 0.2893
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0329 0.0329
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0243
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0039
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0276 0.0276
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.023 0.023
Toxoplasma gondii cathepsin CPL 0.0545 0.3061 0.3361
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1372 0.7777 0.7777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.2106 0.6871
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0102 0.0102
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0132 0.0706 0.2283
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0706 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Giardia lamblia Cathepsin L-like protease 0.0132 0.0706 0.2415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1601 0.9087 0.9087
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Giardia lamblia Thymus-specific serine protease precursor 0.002 0.0067 0.0198
Giardia lamblia Cathepsin B precursor 0.0515 0.2893 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0515 0.2893 0.2893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0545 0.3061 0.3061
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0072 0.0204
Echinococcus multilocularis cysteine protease 0.0545 0.3061 0.3061
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0071 0.0067
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0067 0.0067
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0132 0.0706 0.0706
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0114 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0132 0.0706 0.2283
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0695 0.3917 0.4305
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.002 0.0067 0.0063
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0181 0.0181
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1762 1 1
Trichomonas vaginalis helicase, putative 0.0013 0.0027 0.0056
Echinococcus multilocularis snurportin 1 0.0298 0.1656 0.1656
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Brugia malayi DKFZp564C0469 protein 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0282 0.1563 0.509
Echinococcus granulosus Dipeptidyl peptidase 9 0.0695 0.3917 0.3917
Loa Loa (eye worm) hypothetical protein 0.0034 0.0146 0.0146
Trypanosoma brucei oligopeptidase b 0.0714 0.4024 0.4422
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0084 0.0082
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0132 0.0706 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.0706 0.2283
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0067 0.0187
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0132 0.0706 0.2415
Brugia malayi CXXC zinc finger family protein 0.0056 0.0273 0.0273
Giardia lamblia Hypothetical protein 0.0132 0.0706 0.2415
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0034 0.0034
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0695 0.3917 0.3917
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0072 0.0068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0706 0.0706
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Onchocerca volvulus Prolyl endopeptidase homolog 0.1601 0.9087 0.9086
Echinococcus multilocularis musashi 0.0026 0.0105 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.3061 0.3361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 0.7777 0.7777
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Onchocerca volvulus 0.0545 0.3061 0.3054
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Loa Loa (eye worm) calpain 5 0.0014 0.0036 0.0036
Giardia lamblia Cysteine protease 0.0132 0.0706 0.2415
Echinococcus granulosus cathepsin b 0.1372 0.7777 0.7777
Echinococcus granulosus calpain A 0.002 0.0071 0.0071
Entamoeba histolytica hypothetical protein, conserved 0.0282 0.1563 0.509
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0071 0.0067
Brugia malayi Cathepsin L-like precursor 0.0167 0.0909 0.0909
Echinococcus multilocularis GPCR, family 2 0.0015 0.0042 0.0042
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Schistosoma mansoni hypothetical protein 0.0298 0.1656 0.1656
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.001 0.001
Loa Loa (eye worm) calpain 0.002 0.0071 0.0071
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0132 0.0706 0.0706
Loa Loa (eye worm) cysteine protease 0.0545 0.3061 0.3061
Plasmodium vivax hypothetical protein, conserved 0.0282 0.1563 0.509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3061 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0706 0.2415
Entamoeba histolytica hypothetical protein 0.0132 0.0706 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0706 0.2283
Echinococcus multilocularis nibrin 0.001 0.001 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0042 0.0042
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0035 0.0035
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0366 0.2043 0.2043
Echinococcus granulosus geminin 0.0166 0.09 0.09
Brugia malayi Cathepsin L-like precursor 0.0545 0.3061 0.3061
Schistosoma mansoni hypothetical protein 0.0166 0.09 0.09
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Leishmania major cathepsin L-like protease 0.0545 0.3061 0.3342
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0067 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0042 0.0042
Brugia malayi cathepsin F-like cysteine proteinase 0.0132 0.0706 0.0706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0212 0.0212
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0167 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Treponema pallidum DNA ligase (lig) 0.001 0.001 0.5
Plasmodium falciparum serine repeat antigen 6 0.0132 0.0706 0.2283
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.001 0.00000051037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0071 0.0067
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.048
Schistosoma mansoni topbp1 0.001 0.001 0.001
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0276 0.0276
Plasmodium vivax unspecified product 0.0299 0.1661 0.5411
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0056
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0132 0.0706 0.2283
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0714 0.4024 1
Toxoplasma gondii serine carboxypeptidase s28 protein 0.002 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.001
Schistosoma mansoni lamin 0.0026 0.0105 0.0105
Entamoeba histolytica cysteine protease, putative 0.0299 0.1661 0.5411
Echinococcus granulosus snurportin 1 0.0298 0.1656 0.1656
Trypanosoma cruzi kinesin, putative 0.0014 0.0036 0.0029
Trypanosoma brucei antigen, putative 0.002 0.0071 0.0067
Echinococcus multilocularis hypothetical protein 0.002 0.0071 0.0071
Giardia lamblia Alanyl dipeptidyl peptidase 0.0282 0.1563 0.5386
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Giardia lamblia Cathepsin L precursor 0.0132 0.0706 0.2415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.3061 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0706 0.2283
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0515 0.2893 0.3157
Brugia malayi cathepsin L precursor 0.0132 0.0706 0.0706
Leishmania major cysteine peptidase A (CPA) 0.0545 0.3061 0.3342
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0067 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0212 0.0212
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1601 0.9087 0.9087

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 665 nM Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1 ChEMBL. 15664844
IC50 (functional) = 665 nM Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1 ChEMBL. 15664844

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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