Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | References |
Homo sapiens | excision repair cross-complementation group 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.7682 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0044 | 1 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0038 | 0.7682 | 0.7682 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Giardia lamblia | Flap structure-specific endonuclease | 0.0038 | 0.7682 | 0.5 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0037 | 0.7262 | 0.9453 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus granulosus | flap endonuclease 1 | 0.0038 | 0.7682 | 0.7682 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.7682 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | flap endonuclease 1 | 0.0038 | 0.7682 | 0.7682 |
Schistosoma mansoni | flap endonuclease-1 | 0.0032 | 0.5228 | 0.5228 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.7682 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Entamoeba histolytica | DNA-repair protein, putative | 0.0044 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0038 | 0.7682 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.034 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.034 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.23 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
IC50 (binding) | = 0.23 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.