Detailed information for compound 319813

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 198.199 | Formula: C7H6N2O3S
  • H donors: 2 H acceptors: 3 LogP: 0.52 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1csc2c1c(=O)n(c(=O)[nH]2)O
  • InChi: 1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)
  • InChiKey: VCPLNXWOFQOPTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens excision repair cross-complementation group 5 Starlite/ChEMBL References
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi XPG N-terminal domain containing protein Get druggable targets OG5_128675 All targets in OG5_128675
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum DNA-repair protein rad13, putative Get druggable targets OG5_128675 All targets in OG5_128675
Cryptosporidium parvum XPG, DNA excision repair protein, flap endonuclease Get druggable targets OG5_128675 All targets in OG5_128675
Toxoplasma gondii XPG N-terminal domain-containing protein Get druggable targets OG5_128675 All targets in OG5_128675
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum RAD2 endonuclease, putative Get druggable targets OG5_128675 All targets in OG5_128675
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_128675 All targets in OG5_128675
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to RAD13, excision repair protein Get druggable targets OG5_128675 All targets in OG5_128675
Entamoeba histolytica DNA-repair protein, putative Get druggable targets OG5_128675 All targets in OG5_128675
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128675 All targets in OG5_128675
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis RAD2 Get druggable targets OG5_128675 All targets in OG5_128675
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family Get druggable targets OG5_128675 All targets in OG5_128675
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva hypothetical protein, conserved Get druggable targets OG5_128675 All targets in OG5_128675
Echinococcus multilocularis DNA repair protein complementing XP G cells Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium vivax DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Babesia bovis Rad2 endonuclease, putative Get druggable targets OG5_128675 All targets in OG5_128675
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii XPG I-region, putative Get druggable targets OG5_128675 All targets in OG5_128675
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus DNA repair protein complementing XP G cells Get druggable targets OG5_128675 All targets in OG5_128675
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to RAD13, excision repair protein Get druggable targets OG5_128675 All targets in OG5_128675
Theileria parva DNA repair protein rad2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0052 1 1
Schistosoma mansoni amine GPCR 0.0052 1 1
Echinococcus granulosus neuropeptide s receptor 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0052 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0052 1 1
Brugia malayi sulfakinin receptor protein 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Brugia malayi G protein-coupled receptor 0.0052 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 1 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0038 0.3009 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Echinococcus multilocularis g protein coupled receptor 0.0052 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0052 1 1
Echinococcus granulosus sex peptide receptor 0.0052 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Brugia malayi Dopamine receptor protein 2 0.0052 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Echinococcus multilocularis fmrfamide receptor 0.0052 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 1 1
Brugia malayi larval opioid receptor 0.0052 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0052 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0052 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0052 1 1
Echinococcus multilocularis neuropeptide receptor 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0044 0.5851 1
Brugia malayi hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus multilocularis allatostatin A receptor 0.0052 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis g protein coupled receptor 0.0052 1 1
Brugia malayi follicle stimulating hormone receptor 0.0052 1 1
Schistosoma mansoni biogenic amine receptor 0.0052 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Schistosoma mansoni opsin-like receptor 0.0052 1 1
Plasmodium vivax DNA repair protein RAD2, putative 0.0044 0.5851 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0052 1 1
Echinococcus multilocularis serotonin receptor 0.0052 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi Serotonin receptor 0.0052 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 1 1
Echinococcus granulosus somatostatin receptor 0.0052 1 1
Schistosoma mansoni hypothetical protein 0.0052 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 1 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi Serotonin receptor 0.0052 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 1 1
Echinococcus granulosus serotonin receptor 0.0052 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 1 1
Brugia malayi G-protein coupled receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni opsin-like receptor 0.0052 1 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0038 0.3009 0.5
Echinococcus granulosus allatostatin A receptor 0.0052 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0052 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 1 1
Schistosoma mansoni hypothetical protein 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus granulosus hypothetical protein 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Brugia malayi AKH receptor 0.0052 1 1
Brugia malayi neuropeptide F receptor 0.0052 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0052 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi G-protein coupled receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi Melatonin receptor type 1A 0.0052 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0052 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 1 1
Brugia malayi putative neuropeptide receptor 0.0052 1 1
Echinococcus multilocularis sex peptide receptor 0.0052 1 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0038 0.3009 0.5
Echinococcus multilocularis neuropeptide receptor 0.0052 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 1 1
Brugia malayi RE15519p 0.0052 1 1
Echinococcus granulosus g-protein coupled receptor 0.0052 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Schistosoma mansoni adenoreceptor 0.0052 1 1
Schistosoma mansoni hypothetical protein 0.0052 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0052 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 1 1
Echinococcus granulosus neuropeptide receptor 0.0052 1 1
Schistosoma mansoni histamine h1 receptor 0.0052 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi GnHR receptor homolog 0.0052 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis orexin receptor type 2 0.0052 1 1
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0044 0.5851 0.5851
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Plasmodium falciparum DNA repair protein RAD2, putative 0.0044 0.5851 1
Brugia malayi hypothetical protein 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0052 1 1
Brugia malayi hypothetical protein 0.0052 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 1 1
Schistosoma mansoni biogenic amine receptor 0.0052 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0052 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0052 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0052 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0052 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 1 1
Echinococcus granulosus neuropeptide receptor 0.0052 1 1
Brugia malayi Flap endonuclease-1 0.0038 0.3009 0.0687
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0052 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 1 1
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0044 0.5851 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Brugia malayi Dopamine receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 1 1
Schistosoma mansoni amine GPCR 0.0052 1 1
Echinococcus multilocularis fmrfamide receptor 0.0052 1 1
Schistosoma mansoni hypothetical protein 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Echinococcus multilocularis somatostatin receptor 0.0052 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Schistosoma mansoni amine GPCR 0.0052 1 1
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0044 0.5851 0.4065
Schistosoma mansoni opsin-like receptor 0.0052 1 1
Brugia malayi ORL1-like opioid receptor 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Schistosoma mansoni myosin xvIII 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni amine GPCR 0.0052 1 1
Brugia malayi neuropeptide F receptor 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Onchocerca volvulus 0.0052 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0044 0.5851 0.4065
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Echinococcus multilocularis g protein coupled receptor 0.0052 1 1
Echinococcus granulosus orexin receptor type 2 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni biogenic amine receptor 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.5851 0.4065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 1 1
Echinococcus multilocularis serotonin receptor 0.0052 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 1 1
Giardia lamblia Flap structure-specific endonuclease 0.0038 0.3009 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 1 1
Brugia malayi Dopamine receptor protein 1 0.0052 1 1
Echinococcus granulosus fmrfamide receptor 0.0052 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 1 1
Entamoeba histolytica DNA-repair protein, putative 0.0044 0.5851 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.014 nM Inhibitory concentration against the Flap endonuclease-1 ChEMBL. 15603939
IC50 (binding) = 0.014 nM Inhibitory concentration against the Flap endonuclease-1 ChEMBL. 15603939
IC50 (binding) = 0.145 nM Inhibitory concentration against the xeroderma pigmentosum G ChEMBL. 15603939
IC50 (binding) = 0.145 nM Inhibitory concentration against the xeroderma pigmentosum G ChEMBL. 15603939

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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