Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | References |
Homo sapiens | excision repair cross-complementation group 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Flap structure-specific endonuclease | 0.0038 | 0.8145 | 1 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0044 | 1 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.8145 | 1 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0032 | 0.6181 | 0.6181 |
Brugia malayi | Flap endonuclease-1 | 0.0038 | 0.8145 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.8145 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0038 | 0.8145 | 0.8145 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0044 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0044 | 1 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.8145 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0038 | 0.8145 | 0.8145 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0038 | 0.8145 | 0.8145 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0044 | 1 | 1 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0037 | 0.7809 | 0.9587 |
Echinococcus granulosus | flap endonuclease 1 | 0.0038 | 0.8145 | 0.8145 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0038 | 0.8145 | 0.8145 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0038 | 0.8145 | 0.8145 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0038 | 0.8145 | 0.8145 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0044 | 1 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0038 | 0.8145 | 0.8145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.01 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.023 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
IC50 (binding) | = 0.023 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.