Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus MW2 | Methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 561 aa | 25.1 % |
Onchocerca volvulus | Methionyl-tRNA synthetase | 657 aa | 662 aa | 23.4 % | |
Brugia malayi | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 665 aa | 22.6 % |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 560 aa | 25.2 % |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | Methionyl-tRNA synthetase | 657 aa | 699 aa | 26.5 % |
Dictyostelium discoideum | methionine-tRNA ligase | Methionyl-tRNA synthetase | 657 aa | 698 aa | 25.6 % |
Treponema pallidum | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 755 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0033 | 0.511 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.2919 | 0.5 | |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0033 | 0.511 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0033 | 0.511 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0033 | 0.511 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0026 | 0.2371 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0033 | 0.511 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0021 | 0.04 | 0.0782 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0033 | 0.511 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0033 | 0.511 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0033 | 0.511 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0033 | 0.511 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0019 | 0 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0033 | 0.511 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0033 | 0.511 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0033 | 0.511 | 0.5 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0026 | 0.2371 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0033 | 0.511 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0033 | 0.511 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0033 | 0.511 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0033 | 0.511 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
IC50 (binding) | = 100 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.