Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | excision repair cross-complementation group 5 | Starlite/ChEMBL | References |
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0044 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0044 | 1 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5467 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0044 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0038 | 0.5467 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0038 | 0.5467 | 0.5467 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | flap endonuclease 1 | 0.0038 | 0.5467 | 0.5467 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | XPG N-terminal domain containing protein | 0.0037 | 0.4645 | 0.8496 |
Brugia malayi | Flap endonuclease-1 | 0.0038 | 0.5467 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5467 | 0.5 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0038 | 0.5467 | 0.5467 |
Schistosoma mansoni | flap endonuclease-1 | 0.0032 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5467 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.57 uM | Concentration required for 50% inhibition of Flap endonuclease-1 | ChEMBL. | 15341951 |
IC50 (binding) | = 0.57 uM | Concentration required for 50% inhibition of Flap endonuclease-1 | ChEMBL. | 15341951 |
IC50 (binding) | = 0.9 uM | Concentration required for 50% inhibition of Xeroderma pigmentosum G | ChEMBL. | 15341951 |
IC50 (binding) | = 0.9 uM | Concentration required for 50% inhibition of Xeroderma pigmentosum G | ChEMBL. | 15341951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.