Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | References |
Homo sapiens | excision repair cross-complementation group 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Giardia lamblia | Flap structure-specific endonuclease | 0.0038 | 0.6997 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0038 | 0.6997 | 0.6997 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0044 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.6997 | 0.5 |
Schistosoma mansoni | flap endonuclease-1 | 0.0032 | 0.3816 | 0.3816 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0038 | 0.6997 | 0.6997 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.6997 | 0.5 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.6997 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0038 | 0.6997 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | XPG N-terminal domain containing protein | 0.0037 | 0.6452 | 0.9221 |
Echinococcus granulosus | flap endonuclease 1 | 0.0038 | 0.6997 | 0.6997 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.011 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.011 nM | Inhibitory concentration against the Flap endonuclease-1 | ChEMBL. | 15603939 |
IC50 (binding) | = 0.292 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
IC50 (binding) | = 0.292 nM | Inhibitory concentration against the xeroderma pigmentosum G | ChEMBL. | 15603939 |
Viable cells (functional) | = 4 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 200 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 4 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 200 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 5 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 200 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 5 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 150 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 5 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 200 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 5 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 150 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 6 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 150 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 6 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 150 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 11 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 110 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 11 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of 110 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 18 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 110 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 18 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of 110 uM MMS | ChEMBL. | 15603939 |
Viable cells (functional) | = 87 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of DMSO | ChEMBL. | 15603939 |
Viable cells (functional) | = 87 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 3 uM in the presence of DMSO | ChEMBL. | 15603939 |
Viable cells (functional) | = 96 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of DMSO | ChEMBL. | 15603939 |
Viable cells (functional) | = 96 % | Percent of viable cells by survival assay (colony forming) in T24 bladder carcinoma cells at 1 uM in the presence of DMSO | ChEMBL. | 15603939 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.