Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0445 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0145 | 0.2202 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0445 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0445 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0445 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0445 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0145 | 0.2202 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3745 | 0.1978 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.4815 | 0.4815 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2202 | 0.2202 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0145 | 0.2202 | 0.2202 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0445 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Brugia malayi | adenosine monophosphate deaminase | 0.0145 | 0.2202 | 0.2202 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3745 | 0.1978 |
Leishmania major | adenine aminohydrolase | 0.0445 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.4815 | 0.4815 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0445 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0445 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.