Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | excision repair cross-complementation group 5 | Starlite/ChEMBL | References |
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative dimethyladenosine transferase | 0.0033 | 0.1336 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0044 | 1 | 1 |
Schistosoma mansoni | dimethyladenosine transferase | 0.0033 | 0.1336 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Treponema pallidum | dimethyladenosine transferase | 0.0033 | 0.1336 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0038 | 0.5143 | 0.4394 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0038 | 0.5143 | 0.4394 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0044 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dimethyladenosine transferase | 0.0033 | 0.1336 | 0.5 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0038 | 0.5143 | 0.4394 |
Mycobacterium ulcerans | dimethyladenosine transferase | 0.0033 | 0.1336 | 0.5 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5143 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5143 | 1 |
Mycobacterium tuberculosis | Probable 23S rRNA methyltransferase Erm(37) | 0.0033 | 0.1336 | 0.5 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0044 | 1 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0044 | 1 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0038 | 0.5143 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0038 | 0.5143 | 0.4394 |
Schistosoma mansoni | dimethyladenosine transferase | 0.0033 | 0.1336 | 0.1336 |
Chlamydia trachomatis | rRNA small subunit methyltransferase A | 0.0033 | 0.1336 | 0.5 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0038 | 0.5143 | 0.4394 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0037 | 0.4262 | 0.7685 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0044 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0038 | 0.5143 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0038 | 0.5143 | 0.4394 |
Brugia malayi | Flap endonuclease-1 | 0.0038 | 0.5143 | 1 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0044 | 1 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0038 | 0.5143 | 0.4394 |
Plasmodium falciparum | flap endonuclease 1 | 0.0038 | 0.5143 | 0.4394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.85 uM | Concentration required for 50% inhibition of Xeroderma pigmentosum G | ChEMBL. | 15341951 |
IC50 (binding) | = 1.85 uM | Concentration required for 50% inhibition of Xeroderma pigmentosum G | ChEMBL. | 15341951 |
IC50 (binding) | = 12.2 uM | Concentration required for 50% inhibition of Flap endonuclease-1 | ChEMBL. | 15341951 |
IC50 (binding) | = 12.2 uM | Concentration required for 50% inhibition of Flap endonuclease-1 | ChEMBL. | 15341951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.