Detailed information for compound 324802

Basic information

Technical information
  • TDR Targets ID: 324802
  • Name: 3-prop-2-enylsulfinylsulfanylprop-1-ene
  • MW: 162.273 | Formula: C6H10OS2
  • H donors: 0 H acceptors: 1 LogP: 2.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCS[S+](CC=C)[O-]
  • InChi: 1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2
  • InChiKey: JDLKFOPOAOFWQN-UHFFFAOYSA-N  


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Synonyms

  • 3-allylsulfinylsulfanylprop-1-ene
  • 3-(allylsulfinylthio)-1-propene
  • 3-(allylsulfinylthio)prop-1-ene
  • allicin
  • 539-86-6
  • 2-Propene-1-sulfinic acid, thio-, S-allyl ester
  • 2-Propene-1-sulfinothioic acid, S-2-propenyl ester (9CI)
  • 4-04-00-00007 (Beilstein Handbook Reference)
  • Allylthiosulphinic acid allyl ester
  • BRN 1752823
  • Diallyl thiosulfinate
  • Diallyldisulfid-S-oxid
  • EINECS 208-727-7
  • S-Allyl acrylo-1-sulphinothioate
  • Thio-2-propene-1-sulfinic acid S-allyl ester
  • AIDS-097132
  • 2-Propene-1-sulfinothioic acid S-2-propenyl ester
  • C07600
  • CHEBI:28411
  • AIDS097132
  • NSC707388
  • DADSO
  • S-allyl prop-2-ene-1-sulfinothioate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Mus musculus transient receptor potential cation channel, subfamily A, member 1 Starlite/ChEMBL References
Plasmodium falciparum circumsporozoite (CS) protein Curated by TDR Targets References
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Starlite/ChEMBL References
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like References
Homo sapiens telomerase reverse transcriptase Starlite/ChEMBL No references
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens transient receptor potential cation channel, subfamily A, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum circumsporozoite (CS) protein Get druggable targets OG5_159725 All targets in OG5_159725
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Telomerase reverse transcriptase Get druggable targets OG5_131652 All targets in OG5_131652
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi circumsporozoite (CS) protein Get druggable targets OG5_159725 All targets in OG5_159725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni transient receptor potential cation channel subfamily A member Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax circumsporozoite (CS) protein Get druggable targets OG5_159725 All targets in OG5_159725
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans telomerase reverse transcriptase Get druggable targets OG5_131652 All targets in OG5_131652
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii circumsporozoite protein Get druggable targets OG5_159725 All targets in OG5_159725
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis conserved hypothetical protein Get druggable targets OG5_131652 All targets in OG5_131652
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Telomerase reverse transcriptase homolog Get druggable targets OG5_131652 All targets in OG5_131652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax unspecified product Get druggable targets OG5_159725 All targets in OG5_159725
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_131652 All targets in OG5_131652
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei circumsporozoite (CS) protein Get druggable targets OG5_159725 All targets in OG5_159725
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans telomerase reverse transcriptase Get druggable targets OG5_131652 All targets in OG5_131652
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04984 transient receptor potential cation channel, subfamily A, member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia Cathepsin L precursor cysteine peptidase, Clan CA, family C1, Cathepsin L-like 450 aa 428 aa 21.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi excitatory GABA receptor EXP-1A 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Echinococcus multilocularis cathepsin b 0.0178 0.1244 0.3316
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Onchocerca volvulus 0.0187 0.1341 0.3774
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0187 0.1341 0.2144
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0187 0.1341 0.3588
Loa Loa (eye worm) acetylcholine receptor protein 0.0077 0.0108 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0187 0.1341 0.2144
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1331 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0131 0.0715 0.5375
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0187 0.1341 0.1291
Schistosoma mansoni neurotransmitter gated ion channel 0.0077 0.0108 0.0172
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0103 0.0398 0.299
Echinococcus granulosus biogenic amine 5HT receptor 0.0272 0.2293 0.625
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Brugia malayi hypothetical protein 0.0077 0.0108 0.005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Echinococcus multilocularis cathepsin b 0.0178 0.1244 0.3316
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Schistosoma mansoni nAChR subunit 0.0077 0.0108 0.0172
Brugia malayi Cation transporter family protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0438
Loa Loa (eye worm) hypothetical protein 0.0272 0.2293 0.3665
Toxoplasma gondii RNA-directed DNA polymerase 0.0103 0.0398 1
Echinococcus granulosus ankyrin repeat protein 0.0384 0.3547 0.9755
Onchocerca volvulus 0.0187 0.1341 0.3774
Leishmania major cathepsin L-like protease 0.0186 0.1331 1
Schistosoma mansoni nAChR subunit 0.0077 0.0108 0.0172
Plasmodium vivax unspecified product 0.0354 0.3213 0.9809
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0187 0.1341 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Brugia malayi hypothetical protein 0.0077 0.0108 0.005
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Echinococcus granulosus glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0384 0.3547 0.5668
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0482 0.0426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0072 0.0058 1
Trypanosoma brucei telomerase reverse transcriptase 0.0103 0.0398 0.299
Echinococcus granulosus nAChR subunit 0.0187 0.1341 0.3588
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0187 0.1341 0.3588
Plasmodium vivax circumsporozoite (CS) protein 0.036 0.3274 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0187 0.1341 0.2144
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0187 0.1341 0.3588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0178 0.1244 0.1988
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0187 0.1341 0.1291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0077 0.0108 0.005
Echinococcus multilocularis ankyrin repeat protein 0.0384 0.3547 0.9755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0187 0.1341 0.3588
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Onchocerca volvulus 0.011 0.0482 0.1245
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Toxoplasma gondii cathepsin CPL 0.0072 0.0058 0.1466
Echinococcus granulosus glycine receptor subunit beta 0.0187 0.1341 0.3588
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1331 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0187 0.1341 0.1291
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Echinococcus multilocularis transient receptor potential cation channel 0.0392 0.3634 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Brugia malayi Cation transporter family protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0482 0.0426
Loa Loa (eye worm) fibroinase 0.0072 0.0058 0.0093
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0077 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0187 0.1341 0.3588
Echinococcus multilocularis serotonin receptor 0.0272 0.2293 0.625
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0178 0.1244 0.9349
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0187 0.1341 0.2144
Echinococcus granulosus glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0187 0.1341 0.3588
Onchocerca volvulus 0.0187 0.1341 0.3774
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0058 0.0093
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0058 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0072 0.0058 1
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1331 1
Brugia malayi hypothetical protein 0.0077 0.0108 0.005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0178 0.1244 0.1988
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.011 0.0482 0.077
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0077 0.0108 0.0138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0178 0.1244 0.1988
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) GABA receptor subunit 0.011 0.0482 0.077
Loa Loa (eye worm) hypothetical protein 0.0626 0.6257 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0077 0.0108 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Onchocerca volvulus Putative nachr subunit 0.0187 0.1341 0.3774
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0376 0.3458 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0187 0.1341 0.2144
Schistosoma mansoni neurotransmitter gated ion channel 0.011 0.0482 0.077
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0626 0.6257 1
Plasmodium falciparum telomerase reverse transcriptase 0.0103 0.0398 0.1056
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Schistosoma mansoni neurotransmitter gated ion channel 0.0077 0.0108 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0187 0.1341 0.1291
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0187 0.1341 0.3588
Echinococcus multilocularis nAChR subunit 0.0187 0.1341 0.3588
Echinococcus granulosus glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Loa Loa (eye worm) hypothetical protein 0.0272 0.2293 0.3665
Schistosoma mansoni acetylcholine receptor-related 0.0077 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Brugia malayi Cation transporter family protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0077 0.0108 0.005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0077 0.0108 0.005
Brugia malayi Telomerase reverse transcriptase 0.0273 0.2308 0.2263
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0187 0.1341 0.3588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) ctsf protein 0.0072 0.0058 0.0093
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Onchocerca volvulus 0.0187 0.1341 0.3774
Echinococcus multilocularis nAChR subunit 0.011 0.0482 0.1184
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0187 0.1341 0.1291
Echinococcus granulosus cathepsin b 0.0178 0.1244 0.3316
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0187 0.1341 0.2144
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0187 0.1341 0.2144
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.011 0.0482 0.0426
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0103 0.0398 0.299
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0438
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Echinococcus granulosus glycine receptor subunit beta 0.0187 0.1341 0.3588
Echinococcus granulosus transient receptor potential cation channel 0.0392 0.3634 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0178 0.1244 0.1193
Onchocerca volvulus 0.0077 0.0108 0.0146
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0187 0.1341 0.3588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0077 0.0108 0.0138
Leishmania major telomerase reverse transcriptase, putative 0.0103 0.0398 0.299
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0164 0.1081 0.8125
Echinococcus multilocularis glycine receptor subunit beta 0.0187 0.1341 0.3588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0072 0.0058 0.0093
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0077 0.0108 0.005
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0187 0.1341 0.3588
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0187 0.1341 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Echinococcus multilocularis serotonin receptor 0.0272 0.2293 0.625
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0077 0.0108 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0077 0.0108 0.0138
Onchocerca volvulus 0.0077 0.0108 0.0146
Schistosoma mansoni nAChR subunit 0.0187 0.1341 0.2144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Plasmodium falciparum circumsporozoite (CS) protein 0.036 0.3274 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0187 0.1341 0.3588
Onchocerca volvulus 0.0187 0.1341 0.3774
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0058 0.0093
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Brugia malayi hypothetical protein 0.0077 0.0108 0.005
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0077 0.0108 0.0138
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.011 0.0482 0.077
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0187 0.1341 0.3588
Plasmodium vivax telomerase reverse transcriptase, putative 0.0103 0.0398 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) cysteine protease 0.0072 0.0058 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Leishmania major cathepsin L-like protease 0.0186 0.1331 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0187 0.1341 0.3588
Loa Loa (eye worm) hypothetical protein 0.011 0.0482 0.077
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0187 0.1341 0.1291
Leishmania major cathepsin L-like protease 0.0186 0.1331 1
Giardia lamblia Telomerase catalytic subunit 0.0103 0.0398 1
Onchocerca volvulus 0.011 0.0482 0.1245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0272 0.2293 0.3665
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.1331 1
Entamoeba histolytica hypothetical protein 0.011 0.0482 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0178 0.1244 0.1988
Echinococcus granulosus cathepsin b 0.0178 0.1244 0.3316
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0438
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.011 0.0482 0.0426
Brugia malayi hypothetical protein 0.0077 0.0108 0.005
Loa Loa (eye worm) ACC-1 protein 0.0187 0.1341 0.2144
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0187 0.1341 0.3588
Onchocerca volvulus 0.0187 0.1341 0.3774
Loa Loa (eye worm) hypothetical protein 0.0626 0.6257 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0077 0.0108 0.0172
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0626 0.6257 0.6235
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0178 0.1244 0.1988
Echinococcus multilocularis glycine receptor subunit beta 0.0187 0.1341 0.3588
Echinococcus granulosus nAChR subunit 0.011 0.0482 0.1184
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0187 0.1341 0.3588
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0077 0.0108 0.005
Loa Loa (eye worm) hypothetical protein 0.0072 0.0058 0.0093
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0187 0.1341 0.1291
Leishmania major cysteine peptidase A (CPA) 0.0072 0.0058 0.0438
Loa Loa (eye worm) ACC-1 protein 0.0187 0.1341 0.2144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.1341 0.1291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0187 0.1341 0.2144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0438
Onchocerca volvulus 0.0077 0.0108 0.0146
Loa Loa (eye worm) hypothetical protein 0.0187 0.1341 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1331 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0187 0.1341 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0058 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0187 0.1341 0.3588
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0077 0.0108 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0058 1
Loa Loa (eye worm) LGC-31 protein 0.0187 0.1341 0.2144

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.099 uM Agonist activity at TRPV1 ChEMBL. 16408004
Activity (functional) = 10 uM Agonist activity at TRPA1 ChEMBL. 16408004
Decrease (functional) = 20.5 % Percent decrease in weight of serum cholesterol after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225
Decrease (functional) = 27.6 % Percent decrease in weight of cholesterol in liver wet tissue after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225
Decrease (binding) = 27.6 % Percent decrease in HMG-CoA reductase activity in rat ChEMBL. 15454225
Decrease (binding) = 27.6 % Percent decrease in HMG-CoA reductase activity in rat ChEMBL. 15454225
Decrease (functional) = 39.6 % Percent decrease in weight of triglyceride in liver wet tissue after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225
EC50 (binding) = 1.32 uM Activation of mouse TRPA1 channel ChEMBL. 20356305
EC50 (binding) = 1.91 uM Activation of human TRPA1 channel ChEMBL. 20356305
EC50 (binding) = 51.22 uM Activation of rat TRPV1 channel ChEMBL. 20356305
IC50 (binding) = 0.5 uM Inhibition of telomerase in human SGC7901 cells by TRAP-PCR-ELISA ChEMBL. No reference
IC50 (functional) = 5.21 uM Antiparasitic activity against Plasmodium falciparum ChEMBL. 20692829
IC50 (functional) = 5.5 uM Antiproliferative activity against human HL60 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
IC50 (functional) = 6.8 uM Antimalarial activity against liver stages of Plasmodium berghei infected in human HepG2 cells assessed as growth inhibition of hepatic parasite before invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 3 days by RT-PCR analysis ChEMBL. 22122518
IC50 (functional) = 13.8 uM Antiparasitic activity against Trypanosoma brucei brucei ChEMBL. 20692829
IC50 (functional) = 16.8 uM Antiproliferative activity against human NCI-N87 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
IC50 (functional) = 19.7 uM Antiproliferative activity against human U937 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
IC50 (functional) = 35.3 uM Antiproliferative activity against human Daudi cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
IC50 (functional) = 39.4 uM Antimalarial activity against liver stages of Plasmodium berghei assessed as human HepG2 cells assessed as inhibition of hepatic parasite growth after invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 2 days by RT-PCR analysis ChEMBL. 22122518
IC50 (functional) = 40 uM Antimalarial activity against liver stages of Plasmodium yoelii 17XNL expressing GFP infected in human HepG2 cells transfected with CD81 assessed as growth inhibition of hepatic parasite after 40 hrs by flow cytometry ChEMBL. 22122518
IC50 (functional) = 83.8 uM Antiproliferative activity against multidrug-resistant human HT-29 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
IC50 (functional) = 103.5 uM Antiproliferative activity against human HeLa cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay ChEMBL. 18467007
Inhibition (binding) Inhibition of cathepsin B at 20 uM ChEMBL. 20692829
Inhibition (binding) Inhibition of Trypanosoma brucei rhodesiense rhodesain at 20 uM ChEMBL. 20692829
Inhibition (binding) Inhibition of cathepsin L at 20 uM ChEMBL. 20692829
Inhibition (binding) = 77 % Inhibition of human ENaC alpha-beta-gamma expressed in Xenopus laevis oocytes assessed as effect on transmembrane currents at 100 uM by two-electrode voltage-clamp technique ChEMBL. 22668601
Ki (binding) = 5.31 uM Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 20692829
Ki (binding) = 8.6 uM Inhibition of cathepsin B ChEMBL. 20692829
Ki (binding) = 9.3 uM Inhibition of cathepsin L ChEMBL. 20692829
Ratio (binding) = 2.07 Ratio of HMG-CoA reductase to mevalinate ChEMBL. 15454225
Weight (functional) = 3.59 mg dl-1 Weight of cholesterol in liver wet tissue after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225
Weight (functional) = 9.44 mg dl-1 Weight of triglyceride in liver wet tissue after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225
Weight (functional) = 50.25 mg dl-1 Weight of serum cholesterol after treatment with compound at 20 mg/kg dose for seven days ChEMBL. 15454225

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium berghei ChEMBL23 22122518
Plasmodium falciparum ChEMBL23 20692829
Trypanosoma brucei gambiense 20692829
Homo sapiens ChEMBL23 18467007

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium berghei 3547  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 15630135 16641443
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium yoelii yoelii 3547  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 15630135 16641443

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

11 literature references were collected for this gene.

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