Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Macaca mulatta | Transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.1378 | 0.1378 |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0485 | 0.1378 | 0.1378 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0219 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0485 | 0.1378 | 0.1378 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2152 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0485 | 0.1378 | 0.1378 |
Loa Loa (eye worm) | hypothetical protein | 0.2152 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0485 | 0.1378 | 0.1378 |
Echinococcus granulosus | acetylcholinesterase | 0.0485 | 0.1378 | 0.1378 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2152 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0485 | 0.1378 | 0.1378 |
Loa Loa (eye worm) | carboxylesterase | 0.0485 | 0.1378 | 0.1378 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0485 | 0.1378 | 0.1378 |
Brugia malayi | Carboxylesterase family protein | 0.0485 | 0.1378 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0485 | 0.1378 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0485 | 0.1378 | 0.1378 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.1378 | 0.1378 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 220 nM | Inhibition of [3H]-WIN- 35,428 binding to human dopamine transporter (hDAT) | ChEMBL. | 15546718 |
IC50 (binding) | = 220 nM | Displacement of [3H]WIN 35428 from DAT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | = 220 nM | Inhibition of [3H]-WIN- 35,428 binding to human dopamine transporter (hDAT) | ChEMBL. | 15546718 |
IC50 (binding) | = 220 nM | Displacement of [3H]WIN 35428 from DAT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | = 28 uM | Inhibition of [3H]-citalopram binding to human serotonin transporter (hSERT) | ChEMBL. | 15546718 |
IC50 (binding) | = 28 uM | Inhibition of [3H]-citalopram binding to human serotonin transporter (hSERT) | ChEMBL. | 15546718 |
IC50 (binding) | > 30 uM | Displacement of [3H]citalopram from SERT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | > 30 uM | Displacement of [3H]citalopram from SERT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
Ratio (binding) | = 130 | Ratio of serotonin and dopamine transporter inhibition | ChEMBL. | 15546718 |
Ratio IC50 (binding) | > 127 | Selectivity for rhesus monkey DAT over rhesus monkey SERT | ChEMBL. | 17070057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.