Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0056 | 0.658 | 0.658 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0056 | 0.658 | 0.658 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.8949 | 0.8949 |
Brugia malayi | GSG2 | 0.0072 | 0.8949 | 0.8949 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0078 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0072 | 0.8949 | 0.8949 |
Echinococcus granulosus | dual specificity | 0.0056 | 0.658 | 0.658 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0072 | 0.9085 | 0.9085 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0078 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0078 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 1 | 1 |
Echinococcus granulosus | dual specificity | 0.0078 | 1 | 1 |
Plasmodium falciparum | MO15-related protein kinase | 0.0013 | 0 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0056 | 0.658 | 0.658 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0078 | 1 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0056 | 0.658 | 0.658 |
Echinococcus multilocularis | dual specificity | 0.0056 | 0.658 | 0.658 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0056 | 0.658 | 0.658 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9864 | 0.9864 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0072 | 0.8949 | 0.8949 |
Entamoeba histolytica | protein kinase, putative | 0.0056 | 0.658 | 0.658 |
Echinococcus multilocularis | dual specificity | 0.0078 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.658 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.8949 | 0.8949 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9864 | 0.9864 |
Loa Loa (eye worm) | haspin protein kinase | 0.0072 | 0.8949 | 0.8949 |
Loa Loa (eye worm) | haspin protein kinase | 0.0072 | 0.8949 | 0.8949 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0056 | 0.658 | 0.658 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0056 | 0.658 | 0.658 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0078 | 1 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0056 | 0.658 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0056 | 0.658 | 0.658 |
Echinococcus multilocularis | dual specificity | 0.0056 | 0.658 | 0.658 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0078 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0072 | 0.8949 | 0.8949 |
Entamoeba histolytica | protein kinase, putative | 0.0078 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0072 | 0.8949 | 0.8949 |
Echinococcus granulosus | dual specificity | 0.0056 | 0.658 | 0.658 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0056 | 0.658 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0078 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0072 | 0.8949 | 0.8949 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.658 | 0.658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.8 nM | Binding affinity against delta opioid receptor in mouse hot plate test | ChEMBL. | 15482911 |
Ki (binding) | = 1.9 nM | Binding affinity against mu opioid receptor in mouse hot plate test | ChEMBL. | 15482911 |
Ki (binding) | = 1.9 nM | Binding affinity against mu opioid receptor in mouse hot plate test | ChEMBL. | 15482911 |
Ratio (binding) | = 2.4 | Ratio of binding affinity against mu to that of delta opioid receptor | ChEMBL. | 15482911 |
Ratio (binding) | = 2.4 | Ratio of binding affinity against mu to that of delta opioid receptor | ChEMBL. | 15482911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.