Detailed information for compound 327607

Basic information

Technical information
  • TDR Targets ID: 327607
  • Name: 2,4-dioxo-4-(3-phenoxyphenyl)butanoic acid
  • MW: 284.263 | Formula: C16H12O5
  • H donors: 1 H acceptors: 4 LogP: 2.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)Oc1ccccc1)CC(=O)C(=O)O
  • InChi: 1S/C16H12O5/c17-14(10-15(18)16(19)20)11-5-4-8-13(9-11)21-12-6-2-1-3-7-12/h1-9H,10H2,(H,19,20)
  • InChiKey: RSLTYLKWAOZHJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4-diketo-4-(3-phenoxyphenyl)butyric acid
  • 2,4-dioxo-4-[3-(phenoxy)phenyl]butanoic acid
  • 2,4-diketo-4-[3-(phenoxy)phenyl]butyric acid
  • AIDS-184668
  • AIDS184668
  • Benzenebutanoic acid, a,g-dioxo-3-phenoxy-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens excision repair cross-complementation group 5 Starlite/ChEMBL References
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein, conserved Get druggable targets OG5_128675 All targets in OG5_128675
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva DNA repair protein rad2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi XPG N-terminal domain containing protein Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to RAD13, excision repair protein Get druggable targets OG5_128675 All targets in OG5_128675
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus DNA repair protein complementing XP G cells Get druggable targets OG5_128675 All targets in OG5_128675
Cryptosporidium hominis RAD2 Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis Rad2 endonuclease, putative Get druggable targets OG5_128675 All targets in OG5_128675
Toxoplasma gondii XPG N-terminal domain-containing protein Get druggable targets OG5_128675 All targets in OG5_128675
Entamoeba histolytica DNA-repair protein, putative Get druggable targets OG5_128675 All targets in OG5_128675
Candida albicans similar to RAD13, excision repair protein Get druggable targets OG5_128675 All targets in OG5_128675
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family Get druggable targets OG5_128675 All targets in OG5_128675
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum RAD2 endonuclease, putative Get druggable targets OG5_128675 All targets in OG5_128675
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_128675 All targets in OG5_128675
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum DNA-repair protein rad13, putative Get druggable targets OG5_128675 All targets in OG5_128675
Cryptosporidium parvum XPG, DNA excision repair protein, flap endonuclease Get druggable targets OG5_128675 All targets in OG5_128675
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis DNA repair protein complementing XP G cells Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Plasmodium yoelii XPG I-region, putative Get druggable targets OG5_128675 All targets in OG5_128675
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei DNA repair protein RAD2, putative Get druggable targets OG5_128675 All targets in OG5_128675
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128675 All targets in OG5_128675
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis serotonin receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.6786 0.6786
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0044 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.6786 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis somatostatin receptor 0.004 0.6786 0.3383
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide receptor A26 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptides capa receptor 0.004 0.6786 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide s receptor 0.004 0.6786 0.3383
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.6786 1
Schistosoma mansoni hypothetical protein 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.6786 0.3383
Echinococcus multilocularis fmrfamide receptor 0.004 0.6786 0.3383
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.6786 0.6786
Brugia malayi hypothetical protein 0.004 0.6786 1
Schistosoma mansoni amine GPCR 0.004 0.6786 0.6786
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.6786 0.6786
Echinococcus granulosus g-protein coupled receptor 0.004 0.6786 0.3383
Echinococcus granulosus sex peptide receptor 0.004 0.6786 0.3383
Echinococcus multilocularis g protein coupled receptor 0.004 0.6786 0.3383
Entamoeba histolytica DNA-repair protein, putative 0.0044 1 1
Echinococcus multilocularis g-protein coupled receptor 0.004 0.6786 0.3383
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.6786 0.3383
Echinococcus multilocularis fmrfamide receptor 0.004 0.6786 0.3383
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Schistosoma mansoni amine GPCR 0.004 0.6786 0.6786
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni opsin-like receptor 0.004 0.6786 0.6786
Echinococcus granulosus hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.6786 0.3383
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.6786 0.6786
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis sex peptide receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.6786 0.6786
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.6786 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.6786 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.6786 0.3383
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide receptor 0.004 0.6786 0.3383
Schistosoma mansoni hypothetical protein 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Schistosoma mansoni amine GPCR 0.004 0.6786 0.6786
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Brugia malayi neuropeptide F receptor 0.004 0.6786 1
Echinococcus granulosus serotonin receptor 0.004 0.6786 0.3383
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.6786 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Echinococcus granulosus fmrfamide receptor 0.004 0.6786 0.3383
Brugia malayi Flap endonuclease-1 0.0038 0.5143 0.3491
Brugia malayi hypothetical protein 0.004 0.6786 1
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide receptor 0.004 0.6786 0.3383
Schistosoma mansoni amine GPCR 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi putative neuropeptide receptor 0.004 0.6786 1
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.6786 0.3383
Brugia malayi hypothetical protein 0.004 0.6786 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0044 1 1
Brugia malayi RE15519p 0.004 0.6786 1
Onchocerca volvulus 0.004 0.6786 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus granulosus allatostatin A receptor 0.004 0.6786 0.3383
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.6786 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi Dopamine receptor protein 1 0.004 0.6786 1
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.6786 0.3383
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Brugia malayi hypothetical protein 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.6786 0.3383
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.6786 0.3383
Echinococcus granulosus G protein coupled receptor 139 0.004 0.6786 0.3383
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis orexin receptor type 2 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis g protein coupled receptor 0.004 0.6786 0.3383
Brugia malayi Dopamine receptor 0.004 0.6786 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi ORL1-like opioid receptor 0.004 0.6786 1
Brugia malayi G-protein coupled receptor 0.004 0.6786 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.6786 0.3383
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0038 0.5143 0.5
Loa Loa (eye worm) TYRA-2 protein 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide Y receptor 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptides capa receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Brugia malayi neuropeptide F receptor 0.004 0.6786 1
Schistosoma mansoni myosin xvIII 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi sulfakinin receptor protein 0.004 0.6786 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.6786 0.6786
Echinococcus multilocularis g protein coupled receptor 0.004 0.6786 0.3383
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.6786 0.3383
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.6786 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide s receptor 0.004 0.6786 0.3383
Brugia malayi hypothetical protein 0.004 0.6786 1
Schistosoma mansoni histamine h1 receptor 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.6786 0.6786
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.6786 0.3383
Plasmodium falciparum DNA repair protein RAD2, putative 0.0044 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.6786 0.6786
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.0044 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.6786 0.5
Brugia malayi hypothetical protein 0.004 0.6786 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.6786 0.3383
Brugia malayi GnHR receptor homolog 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.6786 0.6786
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.6786 0.3383
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.6786 0.3383
Schistosoma mansoni biogenic amine receptor 0.004 0.6786 0.6786
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.6786 0.3383
Schistosoma mansoni neuropeptide receptor 0.004 0.6786 0.6786
Schistosoma mansoni biogenic amine receptor 0.004 0.6786 0.6786
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.6786 0.6786
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.6786 0.6786
Echinococcus multilocularis serotonin receptor 0.004 0.6786 0.3383
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.6786 0.3383
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.6786 0.3383
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.6786 0.3383
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.6786 0.3383
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.6786 0.3383
Brugia malayi larval opioid receptor 0.004 0.6786 1
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus granulosus neuropeptide receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi G-protein coupled receptor 0.004 0.6786 1
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.6786 0.3383
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0038 0.5143 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.6786 0.3383
Echinococcus granulosus somatostatin receptor 0.004 0.6786 0.3383
Schistosoma mansoni opsin-like receptor 0.004 0.6786 0.6786
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.6786 0.3383
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi Serotonin receptor 0.004 0.6786 1
Brugia malayi hypothetical protein 0.004 0.6786 1
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0044 1 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0038 0.5143 0.5
Echinococcus granulosus g protein coupled receptor 0.004 0.6786 0.3383
Schistosoma mansoni neuropeptide receptor 0.004 0.6786 0.6786
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi Dopamine receptor protein 2 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Onchocerca volvulus 0.004 0.6786 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.6786 0.6786
Schistosoma mansoni neuropeptide receptor 0.004 0.6786 0.6786
Echinococcus granulosus g protein coupled receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.6786 0.3383
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.6786 0.6786
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Plasmodium vivax DNA repair protein RAD2, putative 0.0044 1 1
Brugia malayi follicle stimulating hormone receptor 0.004 0.6786 1
Echinococcus granulosus neuropeptide Y receptor 0.004 0.6786 0.3383
Brugia malayi Serotonin receptor 0.004 0.6786 1
Onchocerca volvulus 0.004 0.6786 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni opsin-like receptor 0.004 0.6786 0.6786
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.6786 0.6786
Brugia malayi hypothetical protein 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.6786 0.3383
Echinococcus multilocularis allatostatin A receptor 0.004 0.6786 0.3383
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.6786 0.3383
Brugia malayi AKH receptor 0.004 0.6786 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide receptor 0.004 0.6786 0.3383
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.6786 1
Onchocerca volvulus 0.004 0.6786 0.5
Giardia lamblia Flap structure-specific endonuclease 0.0038 0.5143 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.6786 0.6786
Echinococcus granulosus g protein coupled receptor 0.004 0.6786 0.3383
Brugia malayi Melatonin receptor type 1A 0.004 0.6786 1
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.6786 0.6786
Schistosoma mansoni neuropeptide receptor 0.004 0.6786 0.6786
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.6786 0.3383
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.6786 1
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.6786 0.3383
Schistosoma mansoni biogenic amine receptor 0.004 0.6786 0.6786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Onchocerca volvulus 0.004 0.6786 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.6786 0.3383
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.6786 0.3383
Schistosoma mansoni hypothetical protein 0.004 0.6786 0.6786
Onchocerca volvulus 0.004 0.6786 0.5
Schistosoma mansoni amine GPCR 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Brugia malayi G protein-coupled receptor 0.004 0.6786 1
Brugia malayi hypothetical protein 0.004 0.6786 1
Schistosoma mansoni hypothetical protein 0.004 0.6786 0.6786
Brugia malayi hypothetical protein 0.004 0.6786 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383
Trichomonas vaginalis flap endonuclease-1, putative 0.0044 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.6786 0.6786
Echinococcus granulosus orexin receptor type 2 0.004 0.6786 0.3383
Schistosoma mansoni adenoreceptor 0.004 0.6786 0.6786
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.6786 0.3383
Loa Loa (eye worm) hypothetical protein 0.004 0.6786 0.3383

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.44 uM Concentration required for 50% inhibition of Xeroderma pigmentosum G ChEMBL. 15341951
IC50 (binding) = 5.44 uM Concentration required for 50% inhibition of Xeroderma pigmentosum G ChEMBL. 15341951
IC50 (binding) = 7.31 uM Concentration required for 50% inhibition of Flap endonuclease-1 ChEMBL. 15341951
IC50 (binding) = 7.31 uM Concentration required for 50% inhibition of Flap endonuclease-1 ChEMBL. 15341951

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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