Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | purine nucleoside transporter | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 456 aa | 396 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.1096 | 0.2542 | 1 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.0222 | 0.0222 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0185 | 0.0222 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | carboxylesterase | 0.1096 | 0.2542 | 0.2542 |
Brugia malayi | hypothetical protein | 0.0185 | 0.0222 | 0.0871 |
Echinococcus multilocularis | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1096 | 0.2542 | 0.2542 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1096 | 0.2542 | 0.2373 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0185 | 0.0222 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | hormone sensitive lipase | 0.4024 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1096 | 0.2542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4024 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.0222 | 0.0222 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.0222 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.0222 | 0.5 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.1096 | 0.2542 | 0.2542 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0185 | 0.0222 | 0.0222 |
Echinococcus granulosus | carboxylesterase 5A | 0.1096 | 0.2542 | 0.2542 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0185 | 0.0222 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0185 | 0.0222 | 0.0222 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.1096 | 0.2542 | 0.2542 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0185 | 0.0222 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Echinococcus granulosus | neuroligin | 0.0185 | 0.0222 | 0.0222 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 422 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Ki (binding) | = 422 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.