Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3424 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3424 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3424 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0825 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0825 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.3424 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3424 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Binding affinity for human recombinant dopamine receptor D5; ND = Not determined | ChEMBL. | 15293986 |
Ki (binding) | 0 nM | Binding affinity for human recombinant dopamine receptor D5; ND = Not determined | ChEMBL. | 15293986 |
Ki (binding) | = 1651 nM | Binding affinity for human recombinant dopamine receptor D1 | ChEMBL. | 15293986 |
Ki (binding) | = 1651 nM | Binding affinity for human recombinant dopamine receptor D1 | ChEMBL. | 15293986 |
Ki (binding) | = 2408 nM | Binding affinity for human recombinant dopamine receptor D3 | ChEMBL. | 15293986 |
Ki (binding) | = 2408 nM | Binding affinity for human recombinant dopamine receptor D3 | ChEMBL. | 15293986 |
Ki (binding) | = 5317 nM | Binding affinity for human recombinant dopamine receptor D2L | ChEMBL. | 15293986 |
Ki (binding) | = 5317 nM | Binding affinity for human recombinant dopamine receptor D2L | ChEMBL. | 15293986 |
Ki (binding) | > 10000 nM | Binding affinity for human recombinant dopamine receptor D4.4 | ChEMBL. | 15293986 |
Ki (binding) | > 10000 nM | Binding affinity for human recombinant dopamine receptor D4.4 | ChEMBL. | 15293986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.