Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hormone sensitive lipase | 0.2543 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0104 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0616 | 0.2097 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0616 | 0.2097 | 0.2097 |
Onchocerca volvulus | 0.0104 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0104 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.2097 | 0.2097 |
Onchocerca volvulus | 0.0104 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2543 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0104 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.2097 | 0.2097 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0104 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2543 | 1 | 1 |
Onchocerca volvulus | 0.0104 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0616 | 0.2097 | 0.2097 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0616 | 0.2097 | 0.2097 |
Onchocerca volvulus | 0.0104 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2543 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0616 | 0.2097 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0616 | 0.2097 | 0.2097 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0616 | 0.2097 | 0.2097 |
Loa Loa (eye worm) | carboxylesterase | 0.0616 | 0.2097 | 0.2097 |
Onchocerca volvulus | 0.0104 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0616 | 0.2097 | 0.2097 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0104 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0616 | 0.2097 | 0.2097 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2543 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0616 | 0.2097 | 0.2097 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 37 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 37 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 475 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 475 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
Selectivity (binding) | = 13 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 13 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.