Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3901 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1195 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.3901 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1195 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3901 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3901 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3901 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | NA 0 nM | Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human metabotropic glutamate receptor 2 incubated at 30 degree C for 1 hr; NA = not active at 10 uM | ChEMBL. | 16005222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.