TDR Targets

Basic information

Technical information

TDR Targets ID: 328751
Name: [1-[(2-chloropyrimidin-4-yl)oxymethyl]cyclobu tyl]methyl N-[(3S)-1,2-dioxo-1-[[(1R)-1-pheny lethyl]amino]heptan-3-yl]carbamate
MW: 517.017 | Formula: C26H33ClN4O5
H donors: 2 H acceptors: 5 LogP: 5.28 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CCCC[C@@H](C(=O)C(=O)N[C@@H](c1ccccc1)C)NC(=O)OCC1(CCC1)COc1ccnc(n1)Cl
InChi: 1S/C26H33ClN4O5/c1-3-4-11-20(22(32)23(33)29-18(2)19-9-6-5-7-10-19)30-25(34)36-17-26(13-8-14-26)16-35-21-12-15-28-24(27)31-21/h5-7,9-10,12,15,18,20H,3-4,8,11,13-14,16-17H2,1-2H3,(H,29,33)(H,30,34)/t18-,20+/m1/s1
InChiKey: XYVHJUXIUAARMN-QUCCMNQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[1-[(2-chloropyrimidin-4-yl)oxymethyl]cyclobutyl]methyl N-[(1S)-1-[2-oxo-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamate
N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]carbamic acid [1-[(2-chloro-4-pyrimidinyl)oxymethyl]cyclobutyl]methyl ester
N-[(1S)-1-[2-keto-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamic acid [1-[(2-chloropyrimidin-4-yl)oxymethyl]cyclobutyl]methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	fibroinase precursor	0.0025	0.0066	0.0066
Trypanosoma cruzi	cyclin, putative	0.028	1	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Entamoeba histolytica	cyclin family protein	0.0165	0.5513	0.5483
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0066	0.0066
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0066	0.0066
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.139	0.1332
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0115	0.3585	0.3585
Echinococcus multilocularis	cyclin dependent kinase 1	0.0202	0.6951	0.6931
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0145	0.4717	0.4423
Plasmodium vivax	vivapain-1	0.0048	0.0969	0.1394
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0066	0.0066
Giardia lamblia	G2/mitotic-specific cyclin B	0.028	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2292	0.2292
Giardia lamblia	Kinase, CMGC CDK	0.0202	0.6951	0.6931
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0527	0.0527
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Echinococcus multilocularis	G1:S specific cyclin D1	0.004	0.0646	0.0583
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0202	0.6951	0.6931
Leishmania major	cysteine peptidase A (CPA)	0.0082	0.2292	0.1864
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.0066	0.0095
Echinococcus multilocularis	cyclin dependent kinase 5	0.0202	0.6951	0.6931
Echinococcus multilocularis	cathepsin L	0.0048	0.0969	0.0908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0025	0.0066	0.0066
Trichomonas vaginalis	esterase, putative	0.0037	0.0527	0.0464
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0066	0.0066
Echinococcus granulosus	cyclin G2	0.004	0.0646	0.0583
Trichomonas vaginalis	cyclins, putative	0.004	0.0646	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Plasmodium vivax	unspecified product	0.0048	0.0969	0.1394
Brugia malayi	Cathepsin L-like precursor	0.0059	0.139	0.139
Schistosoma mansoni	hypothetical protein	0.004	0.0646	0.0646
Schistosoma mansoni	lipoxygenase	0.0117	0.3663	0.3663
Plasmodium vivax	protein kinase Crk2	0.0202	0.6951	1
Echinococcus granulosus	cathepsin b	0.0145	0.4717	0.4682
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Onchocerca volvulus		0.0082	0.2292	0.2241
Trichomonas vaginalis	cyclin D, putative	0.0165	0.5513	0.5483
Brugia malayi	Cyclin, N-terminal domain containing protein	0.028	1	1
Trichomonas vaginalis	cyclins, putative	0.0155	0.5133	0.51
Entamoeba histolytica	cysteine proteinase, putative	0.0082	0.2292	0.2241
Loa Loa (eye worm)	hypothetical protein	0.0059	0.139	0.139
Schistosoma mansoni	cyclin B3	0.0165	0.5513	0.5513
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0082	0.2292	0.3233
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0082	0.2292	0.2241
Toxoplasma gondii	cathepsin CPL	0.0082	0.2292	0.3233
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Giardia lamblia	Cathepsin B precursor	0.0145	0.4717	0.4682
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2292	0.2292
Loa Loa (eye worm)	hypothetical protein	0.028	1	1
Leishmania major	cyclin	0.028	1	1
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Entamoeba histolytica	cell division protein kinase 2, putative	0.0202	0.6951	0.6931
Loa Loa (eye worm)	MH2 domain-containing protein	0.024	0.8441	0.8441
Loa Loa (eye worm)	ctsf protein	0.0082	0.2292	0.2292
Brugia malayi	hypothetical protein	0.004	0.0646	0.0646
Trichomonas vaginalis	cyclin B, putative	0.004	0.0646	0.0583
Schistosoma mansoni	cyclin l	0.004	0.0646	0.0646
Plasmodium vivax	vivapain-2	0.0082	0.2292	0.3298
Trypanosoma cruzi	cysteine protease, putative	0.0048	0.0969	0.0969
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0082	0.2292	0.3233
Schistosoma mansoni	cathepsin S (C01 family)	0.0025	0.0066	0.0066
Trypanosoma brucei	cdc2-related kinase 1	0.0202	0.6951	0.6781
Echinococcus multilocularis	cyclin t1	0.004	0.0646	0.0583
Onchocerca volvulus		0.028	1	1
Echinococcus granulosus	cyclin y	0.004	0.0646	0.0583
Echinococcus granulosus	cyclin A3 4	0.004	0.0646	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Schistosoma mansoni	cathepsin F (C01 family)	0.0082	0.2292	0.2292
Entamoeba histolytica	hypothetical protein	0.004	0.0646	0.0583
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.3663	0.362
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0202	0.6951	0.6951
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0527	0.0527
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Giardia lamblia	Cyclin B-like protein	0.004	0.0646	0.0583
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.0066	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0048	0.0969	0.1311
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0527	0.0464
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0025	0.0066	0.0066
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0969	0.0908
Entamoeba histolytica	cyclin, putative	0.0165	0.5513	0.5483
Echinococcus granulosus	cyclins	0.0165	0.5513	0.5483
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0527	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0082	0.2292	0.2241
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0145	0.4717	0.4682
Trichomonas vaginalis	cyclin A, putative	0.004	0.0646	0.0583
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Schistosoma mansoni	cyclin d	0.004	0.0646	0.0646
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0969	0.0969
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0066	0.0066
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0969	0.0969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0969	0.0466
Echinococcus granulosus	cathepsin b	0.0145	0.4717	0.4682
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0527	0.0464
Brugia malayi	beta-lactamase family protein	0.0037	0.0527	0.0527
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0066	0.0066
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0527	0.0527
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0165	0.5513	0.5513
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0066	0.0066
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Onchocerca volvulus		0.004	0.0646	0.0583
Brugia malayi	cyclin fold protein 1 variant b	0.004	0.0646	0.0646
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.139	0.1332
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.4717	0.4717
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0527	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0145	0.4717	0.4717
Echinococcus granulosus	cyclin	0.004	0.0646	0.0583
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.0066	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0646	0.0583
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0527	0.5
Echinococcus granulosus	G1:S specific cyclin D1	0.004	0.0646	0.0583
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.004	0.0646	0.0583
Entamoeba histolytica	cyclin, domain containing protein	0.004	0.0646	0.0583
Brugia malayi	cathepsin L-like precursor	0.0059	0.139	0.139
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Schistosoma mansoni	cyclin k	0.004	0.0646	0.0646
Trypanosoma cruzi	cdc2-related kinase 3	0.0202	0.6951	0.6951
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0082	0.2292	0.2292
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0082	0.2292	0.2292
Plasmodium falciparum	cyclin 1	0.004	0.0646	0.0841
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0145	0.4717	0.4717
Echinococcus multilocularis	cyclin y	0.004	0.0646	0.0583
Echinococcus granulosus	cathepsin l1	0.0082	0.2292	0.2241
Trypanosoma cruzi	cyclin 9, putative	0.004	0.0646	0.0646
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Loa Loa (eye worm)	cysteine protease	0.0082	0.2292	0.2292
Schistosoma mansoni	cyclin B	0.028	1	1
Plasmodium vivax	unspecified product	0.0025	0.0066	0.0095
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2292	0.2292
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0048	0.0969	0.0969
Onchocerca volvulus	Cathepsin F homolog	0.0082	0.2292	0.2241
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0082	0.2292	0.2241
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Trichomonas vaginalis	cyclin D, putative	0.0165	0.5513	0.5483
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0527	0.0527
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.004	0.0646	0.0929
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.004	0.0646	0.0841
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0066	0.0066
Giardia lamblia	Hypothetical protein	0.004	0.0646	0.0583
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0066	0.0066
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Entamoeba histolytica	cysteine proteinase, putative	0.0082	0.2292	0.2241
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.5513	0.5483
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.0969	0.0466
Echinococcus granulosus	cathepsin L	0.0048	0.0969	0.0908
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0025	0.0066	0.0095
Giardia lamblia	Hypothetical protein	0.0165	0.5513	0.5483
Echinococcus multilocularis	cyclin B	0.028	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2292	0.2292
Loa Loa (eye worm)	cathepsin B	0.0145	0.4717	0.4717
Echinococcus multilocularis	cyclin	0.004	0.0646	0.0583
Brugia malayi	cathepsin L precursor	0.0025	0.0066	0.0066
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0969	0.0908
Echinococcus granulosus	Cyclin L1	0.004	0.0646	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Schistosoma mansoni	cathepsin F (C01 family)	0.0082	0.2292	0.2292
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Echinococcus granulosus	cyclin k	0.004	0.0646	0.0583
Schistosoma mansoni	lipoxygenase	0.0082	0.2289	0.2289
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0048	0.0969	0.0969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.139	0.1332
Trichomonas vaginalis	cyclins, putative	0.028	1	1
Loa Loa (eye worm)	fibroinase	0.0082	0.2292	0.2292
Trypanosoma cruzi	mitotic cyclin, putative	0.004	0.0646	0.0646
Echinococcus multilocularis	cysteine protease	0.0082	0.2292	0.2241
Plasmodium vivax	vivapain-3	0.0048	0.0969	0.1394
Giardia lamblia	Hypothetical protein	0.004	0.0646	0.0583
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.004	0.0646	0.0646
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0048	0.0969	0.0969
Trypanosoma cruzi	cysteine proteinase, putative	0.0048	0.0969	0.0969
Brugia malayi	cell division control protein 2 homolog	0.0202	0.6951	0.6951
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Trichomonas vaginalis	cyclin B, putative	0.028	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0527	0.0527
Onchocerca volvulus		0.0082	0.2292	0.2241
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Loa Loa (eye worm)	cyclin C	0.004	0.0646	0.0646
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Schistosoma mansoni	serine/threonine protein kinase	0.0202	0.6951	0.6951
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Trichomonas vaginalis	cyclin B3, putative	0.004	0.0646	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Echinococcus granulosus	cyclin dependent kinase 1	0.0202	0.6951	0.6931
Schistosoma mansoni	Cyclin fold protein	0.004	0.0646	0.0646
Echinococcus multilocularis	cyclin A3 4	0.004	0.0646	0.0583
Schistosoma mansoni	serine/threonine protein kinase	0.0202	0.6951	0.6951
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0969	0.0908
Entamoeba histolytica	cyclin, domain containing protein	0.004	0.0646	0.0583
Plasmodium falciparum	protein kinase 5	0.0202	0.6951	1
Echinococcus granulosus	cyclin B	0.028	1	1
Schistosoma mansoni	hypothetical protein	0.004	0.0646	0.0646
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0202	0.6951	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Trichomonas vaginalis	cyclin B, putative	0.028	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.4717	0.4717
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0025	0.0066	0.0066
Giardia lamblia	Cathepsin B precursor	0.0145	0.4717	0.4682
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.004	0.0646	0.0583
Trypanosoma cruzi	cyclin, putative	0.028	1	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0202	0.6951	0.6951
Echinococcus granulosus	cyclin t1	0.004	0.0646	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0969	0.0969
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.0066	0.0095
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0527	0.0464
Onchocerca volvulus	Cyclin L homolog	0.004	0.0646	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0646	0.0583
Trichomonas vaginalis	cyclins, putative	0.028	1	1
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Entamoeba histolytica	cell division protein kinase 2, putative	0.0202	0.6951	0.6931
Loa Loa (eye worm)	transcription factor SMAD2	0.024	0.8441	0.8441
Onchocerca volvulus		0.0082	0.2292	0.2241
Echinococcus multilocularis	Cyclin L1	0.004	0.0646	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0969	0.0908
Entamoeba histolytica	cysteine proteinase 2	0.0048	0.0969	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Trichomonas vaginalis	cyclin B, putative	0.028	1	1
Giardia lamblia	Cyclin A	0.0165	0.5513	0.5483
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0527	0.0464
Brugia malayi	Cathepsin L-like precursor	0.0059	0.139	0.139
Loa Loa (eye worm)	hypothetical protein	0.0059	0.139	0.139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Echinococcus multilocularis	cyclin G2	0.004	0.0646	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Echinococcus granulosus	cyclin dependent kinase	0.0202	0.6951	0.6931
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.139	0.139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trypanosoma brucei	mitotic cyclin 6	0.028	1	1
Brugia malayi	Protein kinase domain containing protein	0.0202	0.6951	0.6951
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.004	0.0646	0.0841
Onchocerca volvulus		0.0082	0.2292	0.2241
Entamoeba histolytica	cyclin, putative	0.028	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0066	0.0066
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0066	0.0066
Toxoplasma gondii	cathepsin B	0.0145	0.4717	0.6755
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.004	0.0646	0.0583
Trichomonas vaginalis	cyclin B3, putative	0.004	0.0646	0.0583
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.139	0.139
Plasmodium falciparum	cyclin	0.0165	0.5513	0.7911
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Echinococcus multilocularis	cyclin k	0.004	0.0646	0.0583
Echinococcus multilocularis	cyclin B3 1	0.0165	0.5513	0.5483
Onchocerca volvulus	Cyclin L homolog	0.004	0.0646	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Trichomonas vaginalis	cyclins, putative	0.004	0.0646	0.0583
Trichomonas vaginalis	cyclin B, putative	0.004	0.0646	0.0583
Trichomonas vaginalis	cyclin B, putative	0.0165	0.5513	0.5483
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0066	0.0066
Plasmodium vivax	cyclin 4, putative	0.004	0.0646	0.0929
Echinococcus granulosus	cathepsin L cysteine protease	0.0048	0.0969	0.0908
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Echinococcus granulosus	cyclin y	0.004	0.0646	0.0583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Mycobacterium ulcerans	lipase LipD	0.0037	0.0527	0.5
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0025	0.0066	0.0066
Brugia malayi	cathepsin L-like cysteine proteinase	0.0025	0.0066	0.0066
Entamoeba histolytica	cysteine proteinase 1, putative	0.0048	0.0969	0.0908
Trichomonas vaginalis	cyclins, putative	0.028	1	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0527	0.0527
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0646	0.0583
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.004	0.0646	0.0125
Echinococcus granulosus	cathepsin l1	0.0059	0.139	0.1332
Leishmania major	mitotic cyclin, putative	0.004	0.0646	0.0125
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.3663	0.362
Echinococcus granulosus	cyclins	0.0165	0.5513	0.5483
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.004	0.0646	0.0583
Trypanosoma brucei	cyclin 3	0.004	0.0646	0.0125
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0082	0.2292	0.2241
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Echinococcus multilocularis	cyclin y	0.004	0.0646	0.0583
Onchocerca volvulus	Protein CNPPD1 homolog	0.004	0.0646	0.0583
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0527	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.4717	0.4717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0527	0.0527
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.8229	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0025	0.0066	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0198	0.6812	0.6812
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0066	0.0066
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0165	0.5513	0.5483
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0025	0.0066	0.0095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.4717	0.4717
Schistosoma mansoni	cyclin G	0.004	0.0646	0.0646
Schistosoma mansoni	cyclins	0.0165	0.5513	0.5513
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trypanosoma cruzi	cysteine proteinase, putative	0.0048	0.0969	0.0969
Echinococcus multilocularis	cathepsin b	0.0145	0.4717	0.4682
Loa Loa (eye worm)	CYL-1 protein	0.004	0.0646	0.0646
Echinococcus multilocularis	cyclin dependent kinase 1	0.0202	0.6951	0.6931
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0646	0.0583
Brugia malayi	cathepsin B-like cysteine proteinase	0.0145	0.4717	0.4717
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Echinococcus granulosus	cyclin b3	0.0165	0.5513	0.5483
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0165	0.5513	0.5483
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0082	0.2292	0.2241
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.004	0.0646	0.0646
Schistosoma mansoni	cathepsin B (C01 family)	0.0025	0.0066	0.0066
Onchocerca volvulus		0.0059	0.139	0.1332
Brugia malayi	Cyclin C	0.004	0.0646	0.0646
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0066	0.0066
Echinococcus granulosus	cyclins	0.0165	0.5513	0.5483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Giardia lamblia	Cyclin fold protein 1, putative	0.004	0.0646	0.0583
Toxoplasma gondii	ABC1 family protein	0.0037	0.0527	0.0669
Echinococcus multilocularis	cathepsin L cysteine protease	0.0082	0.2292	0.2241
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0145	0.4717	0.4423
Entamoeba histolytica	cysteine protease, putative	0.0082	0.2292	0.2241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Echinococcus granulosus	cyclins	0.0165	0.5513	0.5483
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.028	1	1
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0202	0.6951	0.6951
Entamoeba histolytica	cyclin family protein	0.0165	0.5513	0.5483
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Toxoplasma gondii	hypothetical protein	0.0125	0.3965	0.5662
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0969	0.0908
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0025	0.0066	0.0095
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.4717	0.4717
Trichomonas vaginalis	CMGC family protein kinase	0.0202	0.6951	0.6931
Schistosoma mansoni	cyclin G2	0.004	0.0646	0.0646
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0969	0.0908
Leishmania major	cyclin 9, putative	0.004	0.0646	0.0125
Brugia malayi	Papain family cysteine protease containing protein	0.0082	0.2292	0.2292
Brugia malayi	beta-lactamase family protein	0.0037	0.0527	0.0527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Echinococcus multilocularis	cathepsin L cysteine protease	0.0082	0.2292	0.2241
Echinococcus granulosus	cyclins	0.0165	0.5513	0.5483
Trypanosoma cruzi	cyclin 6, putative	0.028	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Echinococcus granulosus	cyclin G2	0.004	0.0646	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Plasmodium vivax	vivapain-2	0.0082	0.2292	0.3298
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0527	0.5
Echinococcus multilocularis	cysteine protease	0.0082	0.2292	0.2241
Trichomonas vaginalis	cyclin A, putative	0.028	1	1
Brugia malayi	hypothetical protein	0.004	0.0646	0.0646
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Loa Loa (eye worm)	hypothetical protein	0.028	1	1
Onchocerca volvulus		0.0037	0.0527	0.0464
Trypanosoma cruzi	cdc2-related kinase 1	0.0202	0.6951	0.6951
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.4717	0.4717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0082	0.2292	0.2241
Echinococcus granulosus	cyclin dependent kinase 5	0.0202	0.6951	0.6931
Schistosoma mansoni	g1/s-specific cyclin C	0.004	0.0646	0.0646
Trichomonas vaginalis	cyclins, putative	0.0165	0.5513	0.5483
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2292	0.2292
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0025	0.0066	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0066	0.0066
Trichomonas vaginalis	cyclin D, putative	0.004	0.0646	0.0583
Brugia malayi	MH2 domain containing protein	0.024	0.8441	0.8441
Trichomonas vaginalis	cyclins, putative	0.028	1	1
Echinococcus granulosus	cysteine protease	0.0048	0.0969	0.0908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Echinococcus multilocularis	cyclin b3	0.0165	0.5513	0.5483
Giardia lamblia	Kinase, CMGC CDK	0.0202	0.6951	0.6931
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0527	0.0758
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0527	0.5
Echinococcus granulosus	cyclins	0.004	0.0646	0.0583
Echinococcus multilocularis	cathepsin b	0.0145	0.4717	0.4682
Brugia malayi	Cyclin, N-terminal domain containing protein	0.004	0.0646	0.0646
Toxoplasma gondii	hypothetical protein	0.004	0.0646	0.0841
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Plasmodium vivax	cyclin homologue, putative	0.004	0.0646	0.0929
Onchocerca volvulus		0.0082	0.2292	0.2241
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.139	0.139
Echinococcus multilocularis	cyclin dependent kinase	0.0202	0.6951	0.6931
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0527	0.0464
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0646	0.0929
Echinococcus granulosus	cyclin B3 1	0.0165	0.5513	0.5483
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0527	0.0464
Trichomonas vaginalis	CMGC family protein kinase	0.0202	0.6951	0.6931
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0025	0.0066	0.0095
Giardia lamblia	Cathepsin B precursor	0.0145	0.4717	0.4682
Trypanosoma cruzi	cdc2-related kinase 1	0.0202	0.6951	0.6951
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0969	0.0908
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.004	0.0646	0.0841
Toxoplasma gondii	cyclin dependent kinase binding protein	0.004	0.0646	0.0841
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Leishmania major	mitotic cyclin, putative	0.004	0.0646	0.0125
Echinococcus multilocularis	cyclin G2	0.004	0.0646	0.0583
Loa Loa (eye worm)	cyclin domain-containing protein	0.0165	0.5513	0.5513
Loa Loa (eye worm)	hypothetical protein	0.004	0.0646	0.0646
Trypanosoma cruzi	mitotic cyclin, putative	0.004	0.0646	0.0646
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0025	0.0066	0.0095
Loa Loa (eye worm)	cyclin domain-containing protein	0.004	0.0646	0.0646
Onchocerca volvulus		0.0037	0.0527	0.0464
Onchocerca volvulus		0.0082	0.2292	0.2241
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0082	0.2292	0.3233
Toxoplasma gondii	cyclin 4, putative	0.004	0.0646	0.0841
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0066	0.0066
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0202	0.6951	0.6781
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0527	0.0527
Onchocerca volvulus	Cathepsin L homolog	0.0082	0.2292	0.2241
Onchocerca volvulus		0.0082	0.2292	0.2241
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0025	0.0066	0.0095
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Trypanosoma cruzi	cruzipain precursor, putative	0.0082	0.2292	0.2292
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0202	0.6951	0.6781
Trichomonas vaginalis	cyclin B3, putative	0.0165	0.5513	0.5483
Trichomonas vaginalis	CMGC family protein kinase	0.0202	0.6951	0.6931
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2292	0.2241
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0048	0.0969	0.0969
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.004	0.0646	0.0841
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2292	0.2241
Entamoeba histolytica	cyclin C, putative	0.004	0.0646	0.0583
Schistosoma mansoni	cathepsin C	0.0025	0.0066	0.0066
Trypanosoma brucei	cdc2-related kinase 3	0.0202	0.6951	0.6781
Loa Loa (eye worm)	hypothetical protein	0.004	0.0646	0.0646
Leishmania major	cathepsin L-like protease	0.0082	0.2292	0.1864
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0202	0.6951	0.6951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0527	0.5
Onchocerca volvulus		0.0037	0.0527	0.0464
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0066	0.0066
Trypanosoma brucei	mitotic cyclin	0.004	0.0646	0.0125
Trypanosoma brucei	cyclin 9	0.004	0.0646	0.0125
Brugia malayi	beta-lactamase	0.0037	0.0527	0.0527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2292	0.1864
Onchocerca volvulus	Cathepsin L homolog	0.0082	0.2292	0.2241
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0646	0.0646
Trypanosoma cruzi	CYC2-like cyclin, putative	0.028	1	1
Trichomonas vaginalis	cyclin B, putative	0.028	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.139	0.139
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2292	0.2292
Echinococcus multilocularis	cyclins	0.0165	0.5513	0.5483

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 85 nM	Inhibitory potency against human Cathepsin K	ChEMBL.	15456249
IC50 (binding)	= 85 nM	Inhibitory potency against human Cathepsin K	ChEMBL.	15456249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 10152540

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 328751