Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2169 | 0.7277 | 0.7277 |
Onchocerca volvulus | 0.0064 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.0249 | 0.0249 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2957 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2957 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.0249 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0136 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.2957 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 0 | 0.5 | |
Onchocerca volvulus | 0.0064 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.2169 | 0.7277 | 0.7277 |
Echinococcus granulosus | carboxylesterase 5A | 0.0136 | 0.0249 | 0.0249 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.0249 | 0.0249 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0136 | 0.0249 | 0.0249 |
Schistosoma mansoni | tyrosine kinase | 0.2119 | 0.7105 | 0.7105 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0249 | 0.0249 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.2169 | 0.7277 | 0.7277 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0249 | 0.0249 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.0249 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.0249 | 0.0249 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2957 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.0249 | 0.0249 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2957 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0136 | 0.0249 | 0.0249 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0136 | 0.0249 | 0.0249 |
Onchocerca volvulus | 0.0064 | 0 | 0.5 | |
Onchocerca volvulus | 0.0064 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.4 uM | Inhibition of [3H]-thymidine uptake in L1210 cells | ChEMBL. | 15369395 |
IC50 (functional) | = 1.4 uM | Inhibition of [3H]-thymidine uptake in L1210 cells | ChEMBL. | 15369395 |
Inhibition (functional) | = 52 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 1 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 52 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 1 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 77 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 10 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 77 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 10 uM | ChEMBL. | 15369395 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15369395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.