Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.1213 | 0.4344 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0885 | 0.2817 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1213 | 0.4344 | 0.4344 |
Echinococcus multilocularis | thymidylate synthase | 0.0336 | 0.0266 | 0.0266 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1213 | 0.4344 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.243 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0885 | 0.2817 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1213 | 0.4344 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0885 | 0.2817 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.243 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1213 | 0.4344 | 0.4344 |
Brugia malayi | thymidylate synthase | 0.0336 | 0.0266 | 0.0613 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0336 | 0.0266 | 0.0266 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1213 | 0.4344 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1213 | 0.4344 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0885 | 0.2817 | 0.5 |
Onchocerca volvulus | 0.0336 | 0.0266 | 0.5 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0336 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.243 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0336 | 0.0266 | 0.0266 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0885 | 0.2817 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.243 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1213 | 0.4344 | 0.4344 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.243 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1213 | 0.4344 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0885 | 0.2817 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1213 | 0.4344 | 0.4344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 148 % | Inhibition of PrPC polymerization by PrP-res at 100 uM | ChEMBL. | 15481988 |
Control (functional) | = 148 % | Inhibition of PrPC polymerization by PrP-res at 100 uM | ChEMBL. | 15481988 |
Inhibition (functional) | -ve 0 | Inhibition of PrP-res formation in SMB (Scrapie mouse brain) cells at 10 uM | ChEMBL. | 15481988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.