Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hormone sensitive lipase | 0.3812 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0754 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3812 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3812 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0754 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3812 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3812 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 15 % | Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips at 100 uM in presence of 1 uM ODQ | ChEMBL. | 16686532 |
Activity (functional) | = 15 % | Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips at 100 uM in presence of 1 uM ODQ | ChEMBL. | 16686532 |
EC50 (functional) | = 15 uM | Vasodilating activity of the compound was determined in rat aorta strip in presence of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) at 100 uM | ChEMBL. | 15546710 |
EC50 (functional) | = 40 uM | Vasodilating activity of the compound was determined in rat aorta strip in absence of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) | ChEMBL. | 15546710 |
EC50 (functional) | = 40 uM | Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips | ChEMBL. | 16686532 |
EC50 (functional) | = 40 uM | Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips | ChEMBL. | 16686532 |
IC50 (functional) | = 2 uM | Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes | ChEMBL. | 15546710 |
IC50 (functional) | = 2 uM | Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane | ChEMBL. | 16686532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.