Detailed information for compound 330212

Basic information

Technical information
  • TDR Targets ID: 330212
  • Name: 1-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin- 1-yl]-4-pyrrolidin-1-ylbutane-1,4-dione
  • MW: 321.415 | Formula: C17H27N3O3
  • H donors: 0 H acceptors: 3 LogP: 0.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@H]1C(=O)N1CCCC1)CCC(=O)N1CCCC1
  • InChi: 1S/C17H27N3O3/c21-15(18-9-1-2-10-18)7-8-16(22)20-13-5-6-14(20)17(23)19-11-3-4-12-19/h14H,1-13H2/t14-/m0/s1
  • InChiKey: HEZUHUXMRNTFNC-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-pyrrolidin-1-yl-butane-1,4-dione
  • 1-[(2S)-2-[oxo(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]-4-(1-pyrrolidinyl)butane-1,4-dione
  • 1-pyrrolidin-1-yl-4-[(2S)-2-pyrrolidin-1-ylcarbonylpyrrolidin-1-yl]butane-1,4-dione
  • 1-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidino]-4-pyrrolidino-butane-1,4-dione
  • 1-[(2S)-2-(oxo-1-pyrrolidinylmethyl)-1-pyrrolidinyl]-4-1-pyrrolidinylbutane-1,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Prolyl endopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.4 %
Dictyostelium discoideum oligopeptidase B Prolyl endopeptidase   710 aa 735 aa 23.7 %
Leishmania mexicana oligopeptidase b,serine peptidase, clan SC, family S9A-like protein Prolyl endopeptidase   710 aa 720 aa 24.7 %
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Trypanosoma congolense oligopeptidase b Prolyl endopeptidase   710 aa 589 aa 27.8 %
Leishmania braziliensis oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 608 aa 26.0 %
Onchocerca volvulus Prolyl endopeptidase   710 aa 722 aa 47.6 %
Trypanosoma brucei oligopeptidase b Prolyl endopeptidase   710 aa 630 aa 26.3 %
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) Prolyl endopeptidase   710 aa 741 aa 25.6 %
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB Prolyl endopeptidase   710 aa 714 aa 26.5 %
Leishmania infantum oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 743 aa 24.4 %
Leishmania major oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.9 %
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Trypanosoma brucei gambiense oligopeptidase B, putative Prolyl endopeptidase   710 aa 629 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cathepsin CPC2 0.0334 0.1665 0.1665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0334 0.1665 0.1634
Loa Loa (eye worm) hypothetical protein 0.1635 1 1
Schistosoma mansoni cathepsin s 0.0528 0.2906 0.2879
Echinococcus granulosus cathepsin l cysteine peptidase 0.1635 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0084 0.0065 0.0065
Plasmodium vivax unspecified product 0.0861 0.5044 0.5041
Echinococcus multilocularis cathepsin L 0.0334 0.1665 0.1634
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Plasmodium falciparum serine repeat antigen 3 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Echinococcus granulosus cathepsin L 0.0334 0.1665 0.1634
Trypanosoma cruzi cysteine proteinase, putative 0.0861 0.5044 0.5025
Onchocerca volvulus 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) calcium channel 0.0401 0.2097 0.2097
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0334 0.1665 0.1659
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Brugia malayi Cathepsin L-like cysteine proteinase 0.1108 0.6621 0.6608
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1108 0.6621 0.6608
Loa Loa (eye worm) hypothetical protein 0.0158 0.054 0.054
Leishmania major cathepsin L-like protease 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0727 0.4185 0.4163
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.008 0.0038 0.5
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0334 0.1665 0.1659
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Onchocerca volvulus Cathepsin L homolog 0.1635 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.1635 1 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.008 0.0038 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0727 0.4185 0.3023
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0334 0.1665 0.1659
Plasmodium vivax vivapain-2 0.1635 1 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0158 0.054 0.0504
Echinococcus granulosus cathepsin L cysteine protease 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1108 0.6621 0.5946
Trypanosoma brucei prolyl endopeptidase 0.0158 0.054 0.0504
Plasmodium falciparum serine repeat antigen 2 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Leishmania major cathepsin L-like protease 0.1635 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0334 0.1665 0.1659
Trypanosoma cruzi major cysteine proteinase, putative 0.0334 0.1665 0.1634
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Brugia malayi Papain family cysteine protease containing protein 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0334 0.1665 0.1659
Plasmodium vivax vivapain-1 0.0861 0.5044 0.5041
Trypanosoma cruzi cysteine proteinase, putative 0.0861 0.5044 0.5025
Echinococcus multilocularis cathepsin L cysteine protease 0.1635 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.054 0.0504
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0401 0.2097 0.2067
Onchocerca volvulus Cathepsin L homolog 0.1635 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0334 0.1665 0.1665
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1606 0.9812 0.9812
Loa Loa (eye worm) cathepsin B 0.0727 0.4185 0.4185
Echinococcus multilocularis cathepsin L cysteine protease 0.1635 1 1
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Echinococcus multilocularis cathepsin b 0.1606 0.9812 0.9812
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0334 0.1665 0.1659
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0861 0.5044 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0334 0.1665 0.1659
Entamoeba histolytica cysteine proteinase, putative 0.1635 1 1
Echinococcus granulosus cathepsin l1 0.1108 0.6621 0.6608
Brugia malayi Papain family cysteine protease containing protein 0.0861 0.5044 0.5025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.1635 1 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.008 0.0038 1
Schistosoma mansoni cathepsin B (C01 family) 0.0334 0.1665 0.1634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Echinococcus multilocularis prolyl endopeptidase 0.0158 0.054 0.0504
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0727 0.4185 0.4163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0334 0.1665 0.1634
Toxoplasma gondii cathepsin CPC1 0.0334 0.1665 0.1665
Entamoeba histolytica cysteine proteinase, putative 0.1635 1 1
Plasmodium falciparum serine repeat antigen 9 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Onchocerca volvulus Cathepsin L homolog 0.0334 0.1665 0.119
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0334 0.1665 0.1659
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.054 0.0504
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0861 0.5044 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0334 0.1665 0.1634
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.054 0.0504
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1606 0.9812 0.9812
Toxoplasma gondii cathepsin CPL 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.1108 0.6621 0.6608
Loa Loa (eye worm) hypothetical protein 0.1606 0.9812 0.9812
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0401 0.2097 0.2067
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0401 0.2097 0.2067
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0244 0.109 0.1056
Plasmodium falciparum serine repeat antigen 5 0.0334 0.1665 0.1659
Leishmania major cathepsin L-like protease 0.1635 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0861 0.5044 0.5025
Toxoplasma gondii IMP dehydrogenas 0.008 0.0038 0.0038
Plasmodium vivax vivapain-3 0.0861 0.5044 0.5041
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Brugia malayi Cathepsin L-like precursor 0.0528 0.2906 0.2879
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0334 0.1665 0.1634
Schistosoma mansoni cathepsin F (C01 family) 0.1635 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0334 0.1665 0.1634
Plasmodium falciparum serine repeat antigen 4 0.0334 0.1665 0.1659
Plasmodium falciparum serine repeat antigen 1 0.0334 0.1665 0.1659
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0334 0.1665 0.1659
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Entamoeba histolytica cysteine proteinase 2 0.0861 0.5044 0.4054
Plasmodium vivax unspecified product 0.0334 0.1665 0.1659
Plasmodium falciparum serine repeat antigen 8 0.0334 0.1665 0.1659
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.0433 1
Echinococcus multilocularis sodium channel protein 0.017 0.0617 0.0582
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0401 0.2097 0.2067
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0334 0.1665 0.1634
Trypanosoma cruzi cruzipain precursor, putative 0.0528 0.2906 0.2879
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0334 0.1665 0.1634
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1635 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0244 0.109 0.1056
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.017 0.0617 0.0582
Echinococcus multilocularis cysteine protease 0.1635 1 1
Plasmodium falciparum serine repeat antigen 7 0.0334 0.1665 0.1659
Loa Loa (eye worm) cysteine protease 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Brugia malayi cathepsin L-like precursor 0.1108 0.6621 0.6608
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Loa Loa (eye worm) fibroinase 0.1635 1 1
Echinococcus granulosus cathepsin b 0.1606 0.9812 0.9812
Echinococcus granulosus cathepsin b 0.1606 0.9812 0.9812
Onchocerca volvulus 0.1635 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0334 0.1665 0.1634
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1108 0.6621 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0861 0.5044 0.5041
Echinococcus multilocularis cathepsin b 0.1606 0.9812 0.9812
Plasmodium vivax vivapain-2 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1108 0.6621 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0727 0.4185 0.4163
Schistosoma mansoni cathepsin S (C01 family) 0.0334 0.1665 0.1634
Brugia malayi Cathepsin L-like precursor 0.1108 0.6621 0.6608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0334 0.1665 0.1659
Trypanosoma cruzi prolyl endopeptidase 0.0158 0.054 0.0504
Echinococcus granulosus cathepsin l1 0.1635 1 1
Leishmania major cathepsin L-like protease 0.1635 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0401 0.2097 0.2067
Echinococcus granulosus cysteine protease 0.0861 0.5044 0.5025
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0528 0.2906 0.2879
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0401 0.2097 0.2067
Brugia malayi Cathepsin L-like precursor 0.1108 0.6621 0.6608
Onchocerca volvulus 0.1635 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0334 0.1665 0.1659
Leishmania major cathepsin L-like protease 0.1635 1 1
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0401 0.2097 0.2097
Onchocerca volvulus 0.1108 0.6621 0.6428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0401 0.2097 0.2067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0334 0.1665 0.1659
Toxoplasma gondii cathepsin B 0.0727 0.4185 0.4185
Brugia malayi cathepsin L precursor 0.0334 0.1665 0.1634
Toxoplasma gondii prolyl endopeptidase 0.0158 0.054 0.054
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0401 0.2097 0.2067
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Echinococcus granulosus cathepsin L 0.0861 0.5044 0.5025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0334 0.1665 0.1634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0334 0.1665 0.1659
Plasmodium vivax unspecified product 0.0528 0.2906 0.2901
Plasmodium vivax serine-repeat antigen (SERA) 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0861 0.5044 0.5025
Loa Loa (eye worm) ctsf protein 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0084 0.0065 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0861 0.5044 0.5025
Leishmania major cathepsin L-like protease 0.1635 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0401 0.2097 0.2067
Trypanosoma cruzi cysteine protease, putative 0.0861 0.5044 0.5025
Schistosoma mansoni voltage-gated cation channel 0.0401 0.2097 0.2067
Trypanosoma cruzi cysteine peptidase, putative 0.0861 0.5044 0.5025
Leishmania major cathepsin L-like protease 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) voltage-dependent calcium channel 0.0084 0.0065 0.0065
Plasmodium falciparum cysteine proteinase falcipain 3 0.1635 1 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.008 0.0038 0.0038
Brugia malayi cathepsin B-like cysteine proteinase 0.1606 0.9812 0.9812
Echinococcus granulosus prolyl endopeptidase 0.0158 0.054 0.0504
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1635 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0528 0.2906 0.2879
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Schistosoma mansoni cathepsin C 0.0334 0.1665 0.1634
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0401 0.2097 0.2067
Onchocerca volvulus 0.1635 1 1
Echinococcus multilocularis cysteine protease 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0065 0.0065
Echinococcus multilocularis cathepsin L 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0528 0.2906 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0401 0.2097 0.2067
Brugia malayi cathepsin L-like cysteine proteinase 0.0334 0.1665 0.1634
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Leishmania major cathepsin L-like protease 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0334 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0861 0.5044 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Echinococcus multilocularis voltage dependent calcium channel 0.0401 0.2097 0.2067
Leishmania major cysteine peptidase A (CPA) 0.1635 1 1
Plasmodium falciparum serine repeat antigen 6 0.0334 0.1665 0.1659
Trypanosoma cruzi cruzipain precursor, putative 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0334 0.1665 0.1665
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0334 0.1665 0.1665
Onchocerca volvulus 0.0334 0.1665 0.119
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.2906 0.2879
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Plasmodium vivax serine-repeat antigen (SERA) 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Onchocerca volvulus Cathepsin F homolog 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Brugia malayi Papain family cysteine protease containing protein 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Brugia malayi fibroinase precursor 0.0334 0.1665 0.1634
Trypanosoma brucei cysteine peptidase C (CPC) 0.0727 0.4185 0.4163
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0401 0.2097 0.2067

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 110 nM In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min ChEMBL. 16033257
IC50 (binding) = 110 nM In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min ChEMBL. 16033257

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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