Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0185 | 0.0258 | 0.0258 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.1 | 0.8364 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0307 | 0.147 | 0.147 |
Echinococcus multilocularis | caspase | 0.0302 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | matrixin family protein | 0.017 | 0.0106 | 0.0106 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0208 | 0.0488 | 0.0488 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.1165 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.1165 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0367 | 0.2068 | 0.2068 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.1165 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0367 | 0.2068 | 0.2068 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.1 | 0.8364 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0302 | 0.1422 | 0.1422 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0208 | 0.0488 | 0.0488 |
Onchocerca volvulus | 0.0208 | 0.0488 | 0.1946 | |
Echinococcus granulosus | caspase | 0.0302 | 0.1422 | 0.1422 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0302 | 0.1422 | 0.1422 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0367 | 0.2068 | 0.2068 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.1 | 0.8364 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.1 | 0.8364 | 0.5 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.036 | 0.1995 | 0.2334 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Brugia malayi | Matrixin family protein | 0.0185 | 0.0258 | 0.0258 |
Brugia malayi | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.1 | 0.8364 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.1165 | 1 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0367 | 0.2068 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0278 | 0.1184 | 0.1184 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0302 | 0.1422 | 0.1422 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.1165 | 1 | 1 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0302 | 0.1422 | 0.1422 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.1165 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0367 | 0.2068 | 0.2068 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.1165 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.1165 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0278 | 0.1184 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.2068 | 0.2068 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.1165 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP | = 2.896 | The octanol/water partition coefficient expressed in logarithmic form | ChEMBL. | 15990300 |
GI50 (functional) | NA 0 uM | Concentration required for 50% reduction of cellular net growth of HL60 human leukemia cells; na=no activity | ChEMBL. | 15990300 |
GI50 (functional) | NA 0 uM | Concentration required for 50% reduction of cellular net growth of MCF-7 human breast cancer cells | ChEMBL. | 15990300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.