TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.866 | Formula: C22H19ClN4
H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1nc(nc(c1)c1c[nH]c2c1cccc2)N1CCCC1
InChi: 1S/C22H19ClN4/c23-16-9-7-15(8-10-16)20-13-21(26-22(25-20)27-11-3-4-12-27)18-14-24-19-6-2-1-5-17(18)19/h1-2,5-10,13-14,24H,3-4,11-12H2
InChiKey: ZXJJNDGELJZYAQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin F-like cysteine proteinase	0.0055	0.0081	0.0081
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0055	0.0081	0.0451
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0081	0.0081
Brugia malayi	Cathepsin L-like precursor	0.0128	0.0887	0.0887
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.1309
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.0681
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.0618	0.0618
Echinococcus granulosus	calpain 5	0.011	0.0696	0.0696
Echinococcus granulosus	cathepsin l1	0.0128	0.0887	0.0887
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0049	0.0017	0.0017
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.1437	0.1422
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0696	0.0681
Entamoeba histolytica	cysteine protease, putative	0.0177	0.1437	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0055	0.0081	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2725	0.2725
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0104	0.0631	0.1791
Echinococcus granulosus	cathepsin l1	0.0177	0.1437	0.1437
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Echinococcus multilocularis	calpain	0.011	0.0696	0.0696
Entamoeba histolytica	cysteine proteinase, putative	0.0104	0.0631	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0081	0.0081
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0946	1	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0887	0.0887
Loa Loa (eye worm)	calpain family protein 1	0.0215	0.1866	0.1866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Schistosoma mansoni	Mername-AA248 (C02 family)	0.011	0.0696	0.0696
Onchocerca volvulus		0.0177	0.1437	0.9578
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0081	0.0081
Schistosoma mansoni	cathepsin C	0.0055	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0887	0.0887
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0104	0.0631	0.0631
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0259	0.2356	0.2356
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0055	0.0081	0.0451
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0055	0.0081	0.0451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0177	0.1437	0.4419
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0331	0.3149	0.3137
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0696	0.1309
Trypanosoma cruzi	cruzipain precursor, putative	0.0177	0.1437	0.1422
Echinococcus multilocularis	cysteine protease	0.0177	0.1437	0.1437
Trypanosoma cruzi	cysteine proteinase, putative	0.0104	0.0631	0.0615
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0055	0.0081	0.0081
Onchocerca volvulus		0.0177	0.1437	0.9578
Onchocerca volvulus		0.0128	0.0887	0.5695
Plasmodium vivax	vivapain-1	0.0104	0.0631	0.4322
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0128	0.0887	0.0887
Echinococcus multilocularis	cathepsin b	0.0946	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.0887	0.2627
Toxoplasma gondii	cathepsin B	0.0331	0.3149	1
Plasmodium vivax	unspecified product	0.0104	0.0631	0.4322
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0946	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0055	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0331	0.3149	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Toxoplasma gondii	cathepsin CPL	0.0177	0.1437	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0077	0.0327	0.1814
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.115	0.115
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.2125	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0177	0.1437	0.1437
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.1309
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.0081	0.0081
Echinococcus multilocularis	cysteine protease	0.0177	0.1437	0.1437
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0696	0.1309
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.1437	0.1422
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0946	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Onchocerca volvulus		0.0182	0.1496	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Onchocerca volvulus		0.0177	0.1437	0.9578
Loa Loa (eye worm)	cathepsin B	0.0331	0.3149	0.3149
Trypanosoma cruzi	kinesin, putative	0.0077	0.0327	0.031
Echinococcus granulosus	calpain A	0.0306	0.2873	0.2873
Brugia malayi	cathepsin L-like precursor	0.0128	0.0887	0.0887
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0306	0.2873	0.2873
Echinococcus multilocularis	cathepsin L cysteine protease	0.0177	0.1437	0.1437
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.0081	0.0064
Entamoeba histolytica	cysteine proteinase 2	0.0104	0.0631	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0946	1	1
Echinococcus granulosus	cysteine protease	0.0104	0.0631	0.0631
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0946	1	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0055	0.0081	0.0451
Brugia malayi	calpain family protein 1	0.0293	0.2725	0.2725
Brugia malayi	fibroinase precursor	0.0055	0.0081	0.0081
Plasmodium vivax	calpain, putative	0.011	0.0696	0.4786
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0177	0.1437	0.1437
Brugia malayi	cathepsin F-like cysteine proteinase	0.0049	0.0017	0.0017
Schistosoma mansoni	cathepsin s	0.0049	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0842	0.8836	0.8836
Trypanosoma cruzi	kinesin, putative	0.0077	0.0327	0.031
Echinococcus multilocularis	calpain family protein 1, d	0.0215	0.1866	0.1866
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0055	0.0081	0.0081
Entamoeba histolytica	cysteine proteinase, putative	0.0177	0.1437	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Loa Loa (eye worm)	cysteine protease	0.0177	0.1437	0.1437
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0946	1	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0055	0.0081	0.0081
Entamoeba histolytica	protein kinase, putative	0.0077	0.0327	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0177	0.1437	0.4419
Plasmodium vivax	serine-repeat antigen (SERA)	0.0055	0.0081	0.0451
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.1309
Echinococcus multilocularis	cathepsin L	0.0055	0.0081	0.0081
Schistosoma mansoni	calpain-7 (C02 family)	0.011	0.0696	0.0696
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Plasmodium vivax	unspecified product	0.0055	0.0081	0.0451
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0081	0.0081
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0055	0.0081	0.0451
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Entamoeba histolytica	cysteine proteinase, putative	0.0104	0.0631	0.4054
Echinococcus multilocularis	calpain 5	0.011	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0618	0.0618
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0104	0.0631	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0293	0.2725	0.2725
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0081	0.0081
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0331	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.0887	0.2627
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0128	0.0887	0.0871
Schistosoma mansoni	calpain-7 (C02 family)	0.011	0.0696	0.0696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Onchocerca volvulus	Cathepsin L homolog	0.0177	0.1437	0.9578
Brugia malayi	calpain 7	0.011	0.0696	0.0696
Entamoeba histolytica	cysteine proteinase 1, putative	0.0104	0.0631	0.4054
Echinococcus granulosus	cathepsin L	0.0055	0.0081	0.0081
Echinococcus multilocularis	cathepsin L	0.0104	0.0631	0.0631
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0177	0.1437	0.1437
Loa Loa (eye worm)	calpain	0.011	0.0696	0.0696
Brugia malayi	calpain 5	0.0077	0.0327	0.0327
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Onchocerca volvulus		0.0177	0.1437	0.9578
Giardia lamblia	Cathepsin B precursor	0.0331	0.3149	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0104	0.0631	0.0615
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0696	0.0681
Onchocerca volvulus		0.0177	0.1437	0.9578
Entamoeba histolytica	cysteine proteinase, putative	0.0104	0.0631	0.4054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.115	0.115
Echinococcus granulosus	calpain	0.011	0.0696	0.0696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Entamoeba histolytica	cysteine proteinase, putative	0.0177	0.1437	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.0081	0.0081
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0055	0.0081	0.0081
Loa Loa (eye worm)	ctsf protein	0.0177	0.1437	0.1437
Brugia malayi	Papain family cysteine protease containing protein	0.0177	0.1437	0.1437
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0055	0.0081	0.0451
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.0681
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0017	0.0017
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0177	0.1437	0.1437
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0177	0.1437	0.1437
Brugia malayi	calpain family protein 1	0.0293	0.2725	0.2725
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0696	0.1309
Plasmodium vivax	vivapain-2	0.0177	0.1437	1
Brugia malayi	Cathepsin L-like precursor	0.0128	0.0887	0.0887
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0055	0.0081	0.0451
Leishmania major	cysteine peptidase A (CPA)	0.0177	0.1437	0.3932
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Onchocerca volvulus		0.0177	0.1437	0.9578
Onchocerca volvulus	Cathepsin F homolog	0.0177	0.1437	0.9578
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0696	0.0681
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0017	0.0017
Onchocerca volvulus	Cathepsin L homolog	0.0177	0.1437	0.9578
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	calpain 5	0.0077	0.0327	0.0327
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0055	0.0081	0.0451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.0696	0.1309
Echinococcus multilocularis	cathepsin b	0.0946	1	1
Brugia malayi	cathepsin L precursor	0.0055	0.0081	0.0081
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.1309
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0055	0.0081	0.0081
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0055	0.0081	0.0081
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0055	0.0081	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.1437	0.3932
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Brugia malayi	Papain family cysteine protease containing protein	0.0104	0.0631	0.0631
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0177	0.1437	1
Schistosoma mansoni	calpain C (C02 family)	0.011	0.0696	0.0696
Entamoeba histolytica	cysteine proteinase, putative	0.0104	0.0631	0.4054
Schistosoma mansoni	hypothetical protein	0.0103	0.0618	0.0618
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0177	0.1437	0.1437
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0081	0.0081
Plasmodium vivax	serine-repeat antigen (SERA)	0.0055	0.0081	0.0451
Echinococcus granulosus	cathepsin b	0.0946	1	1
Plasmodium vivax	vivapain-3	0.0104	0.0631	0.4322
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0696	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Echinococcus granulosus	cathepsin L cysteine protease	0.0104	0.0631	0.0631
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0306	0.2873	0.2873
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Echinococcus granulosus	calpain 7 C02 family	0.011	0.0696	0.0696
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0306	0.2873	0.2873
Schistosoma mansoni	cathepsin F (C01 family)	0.0128	0.0887	0.0887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0081	0.0081
Echinococcus granulosus	calpain A	0.011	0.0696	0.0696
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.0887	0.5946
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.0681
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Echinococcus granulosus	cathepsin L	0.0104	0.0631	0.0631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0887	0.0887
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Giardia lamblia	Cathepsin B precursor	0.0331	0.3149	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0331	0.3149	1
Schistosoma mansoni	calpain (C02 family)	0.011	0.0696	0.0696
Leishmania major	cathepsin L-like protease	0.0177	0.1437	0.3932
Schistosoma mansoni	cathepsin F (C01 family)	0.0177	0.1437	0.1437
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.0081	0.0064
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0081	0.0081
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0055	0.0081	0.0081
Echinococcus multilocularis	calpain 7 (C02 family)	0.011	0.0696	0.0696
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.115	0.115
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Brugia malayi	Papain family cysteine protease containing protein	0.0104	0.0631	0.0631
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0696	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1437	0.1437
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.011	0.0696	0.0681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0104	0.0631	0.1076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Schistosoma mansoni	cathepsin F (C01 family)	0.0177	0.1437	0.1437
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0177	0.1437	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0104	0.0631	0.0615
Echinococcus multilocularis	hypothetical protein	0.011	0.0696	0.0696
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0055	0.0081	0.0451
Echinococcus multilocularis	calpain A	0.0306	0.2873	0.2873
Echinococcus granulosus	cathepsin b	0.0946	1	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0017	0.0017
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0696	0.0681
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.1437	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0215	0.1866	0.1866
Echinococcus multilocularis	cathepsin L cysteine protease	0.0177	0.1437	0.1437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	calpain family protein 1	0.0293	0.2725	0.2725
Plasmodium vivax	vivapain-2	0.0177	0.1437	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0104	0.0631	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0177	0.1437	0.1437
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0696	0.0681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0104	0.0631	0.1076
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0104	0.0631	0.0631
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0104	0.0631	0.0631
Giardia lamblia	Cathepsin B precursor	0.0331	0.3149	1
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0151	0.115	0.115
Trypanosoma cruzi	cysteine proteinase, putative	0.0104	0.0631	0.0615
Onchocerca volvulus		0.0177	0.1437	0.9578
Trypanosoma brucei	antigen, putative	0.011	0.0696	0.1309
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0177	0.1437	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0331	0.3149	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.1437	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1496	0.1496
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0306	0.2873	0.2873
Entamoeba histolytica	cysteine protease, putative	0.0104	0.0631	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0104	0.0631	0.0615
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.1437	0.4419
Loa Loa (eye worm)	fibroinase	0.0177	0.1437	0.1437

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 10 ug ml-1	In vitro minimum inhibitory concentration against Plasmodium falciparum NF-54 strain development during 40 hours incubation	ChEMBL.	15925306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 333425