Detailed information for compound 335060

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 652.769 | Formula: C34H52O12
  • H donors: 2 H acceptors: 6 LogP: 2.83 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCC(=O)O[C@@H]1[C@@H](OC(=O)/C(=C\C)/C)C(=C2[C@H]1[C@@](C)(OC(=O)C)C[C@@H]([C@]1([C@H]2O[C@H]([C@@]1(C)O)OCC)O)OC(=O)CCC)C
  • InChi: 1S/C34H52O12/c1-10-14-15-17-24(37)43-28-26-25(20(6)27(28)44-30(38)19(5)12-3)29-34(40,33(9,39)31(45-29)41-13-4)22(42-23(36)16-11-2)18-32(26,8)46-21(7)35/h12,22,26-29,31,39-40H,10-11,13-18H2,1-9H3/b19-12-/t22-,26+,27-,28-,29-,31+,32-,33+,34+/m0/s1
  • InChiKey: ZCNJJXBLADLETA-HOBZHRSSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.153 0.3677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0669 0.1313
Schistosoma mansoni hypothetical protein 0.0065 0.0751 0.1474
Brugia malayi Calcitonin receptor-like protein seb-1 0.0031 0.0253 0.0322
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0054 0.058 0.0589
Brugia malayi Thioredoxin reductase 0.0047 0.0477 0.0609
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1367 0.2683
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1367 0.3119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Loa Loa (eye worm) hypothetical protein 0.0065 0.0751 0.0958
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1367 0.1745
Mycobacterium tuberculosis Probable reductase 0.0106 0.1355 0.325
Schistosoma mansoni hypothetical protein 0.0065 0.0751 0.1474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0125 0.0127
Echinococcus multilocularis geminin 0.0106 0.1359 0.138
Echinococcus multilocularis peregrin 0.002 0.0084 0.0085
Echinococcus granulosus metabotropic glutamate receptor 2 0.0054 0.058 0.058
Echinococcus granulosus Ankyrin 0.0014 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0065 0.075 0.0956
Loa Loa (eye worm) protein-tyrosine phosphatase 0.036 0.5095 0.6502
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0079 0.0951 0.0965
Loa Loa (eye worm) hypothetical protein 0.0479 0.6841 0.873
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0199 0.0202
Schistosoma mansoni metabotropic glutamate receptor 0.0031 0.0251 0.0492
Giardia lamblia PHD finger protein 15 0.002 0.0084 0.2924
Plasmodium vivax hypothetical protein, conserved 0.002 0.0084 0.1228
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0125 0.0713
Loa Loa (eye worm) hypothetical protein 0.0079 0.0951 0.1213
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1367 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0125 0.2131
Brugia malayi beta-lactamase 0.0023 0.0125 0.0159
Leishmania major hypothetical protein, conserved 0.0023 0.0125 0.0186
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0199 0.0199
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.036 0.5095 0.5095
Schistosoma mansoni jumonji domain containing protein 0.0052 0.0553 0.1085
Echinococcus granulosus lysine specific demethylase 5A 0.0024 0.0146 0.0146
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0125 0.0234
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.153 0.3526
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0859 0.0872
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0029 0.5
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0293 0.4109 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Loa Loa (eye worm) hypothetical protein 0.0065 0.0751 0.0958
Mycobacterium ulcerans beta-lactamase 0.0023 0.0125 0.0234
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1367 0.328
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0125 0.0234
Brugia malayi phosphofructokinase 0.0107 0.1367 0.1744
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0125 0.0234
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.5158 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0084 0.1228
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0477 0.0484
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0217 0.4201
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0125 0.0186
Onchocerca volvulus 0.0065 0.0751 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0477 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.006 0.0669 0.0669
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1367 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1367 0.1388
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0125 0.0245
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.036 0.5095 0.5174
Schistosoma mansoni hypothetical protein 0.002 0.0084 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0125 0.0713
Echinococcus granulosus metabotropic glutamate receptor 5 0.0079 0.0951 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0669 0.1313
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0033 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Echinococcus granulosus peregrin 0.002 0.0084 0.0084
Brugia malayi Death domain containing protein 0.0014 0.000000012083 0.000000015415
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.153 0.3677
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0084 0.1228
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0146 0.0286
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0146 0.0286
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0125 0.0713
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0125 0.0159
Toxoplasma gondii ABC1 family protein 0.0023 0.0125 0.2131
Brugia malayi hypothetical protein 0.012 0.1556 0.1985
Mycobacterium ulcerans isocitrate lyase Icl 0.0293 0.4109 1
Schistosoma mansoni hypothetical protein 0.0106 0.1359 0.2667
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.021
Loa Loa (eye worm) hypothetical protein 0.0065 0.0751 0.0958
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1355 0.325
Brugia malayi beta-lactamase family protein 0.0023 0.0125 0.0159
Brugia malayi hypothetical protein 0.0065 0.0751 0.0958
Brugia malayi Metabotropic glutamate receptor precursor. 0.0064 0.0733 0.0935
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0217 0.1406
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0146 0.0148
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0217 1
Loa Loa (eye worm) glutamate receptor 0.0025 0.0162 0.0207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0031 0.0253 0.0322
Brugia malayi 6-phosphofructokinase 0.0107 0.1367 0.1744
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.006 0.0669 0.0853
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0125 0.0186
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000000012083 0.000000023714
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0477 0.0477
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1367 0.2683
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0125 0.0713
Onchocerca volvulus 0.0023 0.0125 0.1659
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0293 0.4109 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.5158 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0546 0.7836 1
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0125 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1367 1
Brugia malayi jmjC domain containing protein 0.0024 0.0146 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.153 0.3677
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1367 0.2609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.006 0.0669 0.0669
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0217 0.4201
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.075 0.075
Onchocerca volvulus Alhambra homolog 0.002 0.0084 0.112
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1367 0.1745
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0029 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0146 0.0186
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0591 0.8496 0.8628
Mycobacterium ulcerans lipase LipD 0.0023 0.0125 0.0234
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0084 0.0107
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1367 0.1745
Schistosoma mansoni metabotropic glutamate receptor 0.0054 0.058 0.1139
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0125 0.0234
Echinococcus multilocularis Ankyrin 0.0014 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0021 0.0107 0.0136
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0217 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0002 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Plasmodium falciparum thioredoxin reductase 0.0047 0.0477 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1367 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0217 0.0748
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0033 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1355 0.325
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0217 0.4201
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0084 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0125 0.0125
Brugia malayi Protein-tyrosine phosphatase containing protein 0.036 0.5095 0.65
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0217 0.1406
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0033 0.0042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.075 0.0761
Schistosoma mansoni hypothetical protein 0.0023 0.0124 0.0244
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1367 0.2609
Echinococcus granulosus MAM 0.0065 0.0751 0.0751
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0477 0.0609
Mycobacterium leprae Isocitrate lyase 0.0137 0.1815 0.4244
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0144 0.1919 0.4632
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1367 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0477 0.1098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.006 0.0669 0.0679
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0084 0.0165
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1367 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1367 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0124 0.0124
Mycobacterium ulcerans isocitrate lyase AceAb 0.0293 0.4109 1
Onchocerca volvulus 0.0065 0.0751 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1367 0.328
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0058 0.0645 0.0822
Brugia malayi Protein kinase domain containing protein 0.0546 0.7839 1
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0124 0.0244
Brugia malayi Serotonin receptor 0.0465 0.6648 0.8481
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1367 0.1367
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0396 0.0505
Echinococcus multilocularis MAM 0.0065 0.0751 0.0762
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0125 0.0713
Plasmodium vivax glutathione reductase, putative 0.0047 0.0477 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0125 0.0234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.006 0.0669 0.0854
Trichomonas vaginalis esterase, putative 0.0023 0.0125 0.0713
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0293 0.4109 1
Echinococcus granulosus geminin 0.0106 0.1359 0.1359
Echinococcus multilocularis conserved hypothetical protein 0.0683 0.9848 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Brugia malayi hypothetical protein 0.0023 0.0124 0.0159
Brugia malayi PHD-finger family protein 0.002 0.0084 0.0107
Brugia malayi metabotropic glutamate receptor type 2 0.0031 0.0251 0.032
Brugia malayi glutathione reductase 0.0047 0.0477 0.0609
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1355 0.325
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0217 0.4201
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0125 0.0234
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0217 0.4201
Toxoplasma gondii thioredoxin reductase 0.0047 0.0477 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0029 0.5
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1355 0.3088
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0031 0.0253 0.0322
Plasmodium falciparum phd finger protein, putative 0.002 0.0084 0.1228
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0125 0.0159
Brugia malayi Uncoordinated protein 44 0.0014 0.000000012083 0.000000015415
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1367 0.2609
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000000012083 0.00000001227
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0217 0.4201
Mycobacterium tuberculosis Conserved protein 0.0023 0.0125 0.0234
Mycobacterium tuberculosis Conserved protein 0.0023 0.0125 0.0234
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0073 0.0862 0.1692
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0125 0.0245
Loa Loa (eye worm) hypothetical protein 0.0186 0.2534 0.3234
Loa Loa (eye worm) hypothetical protein 0.0312 0.439 0.5603
Brugia malayi Bromodomain containing protein 0.002 0.0084 0.0107
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0057
Plasmodium falciparum glutathione reductase 0.0047 0.0477 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0217 0.4201
Mycobacterium tuberculosis Conserved protein 0.0023 0.0125 0.0234
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000000012083 0.000000012083
Loa Loa (eye worm) hypothetical protein 0.0364 0.5158 0.6582
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0217 0.1406
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0217 1
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0125 0.0234
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0125 0.0234
Onchocerca volvulus 0.0023 0.0125 0.1659
Loa Loa (eye worm) glutamate receptor 0.0064 0.0733 0.0936
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.006 0.0669 0.0679
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0477 0.0873
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0859 0.0859
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0477 1
Leishmania major trypanothione reductase 0.0047 0.0477 0.0873
Onchocerca volvulus 0.0023 0.0125 0.1659
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0125 0.0234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0136
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.5158 1
Brugia malayi beta-lactamase family protein 0.0023 0.0125 0.0159
Schistosoma mansoni hypothetical protein 0.0106 0.1359 0.2667
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1355 0.325
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1367 1
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0084 0.0084
Brugia malayi 6-phosphofructokinase 0.0107 0.1367 0.1744
Trypanosoma brucei trypanothione reductase 0.0047 0.0477 0.0873
Loa Loa (eye worm) beta-lactamase 0.0023 0.0125 0.0159
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.036 0.5095 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0125 0.0234
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0374
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0293 0.4109 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.5158 0.658
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0029 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0669 0.1313
Brugia malayi Protein kinase domain containing protein 0.0014 0.000000012083 0.000000015415
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0124 0.0126
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1355 0.325

Activities

Activity type Activity value Assay description Source Reference
RIC50 (binding) = 0.52 Inhibitory potency against sarco- endoplasmic reticulum calcium-ATPase in relative to thapsigargin ChEMBL. 15828839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.