Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0287 | 0.5523 | 0.6348 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0391 | 0.8 | 0.5 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0301 | 0.0887 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0301 | 0.0499 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0391 | 0.8 | 1 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 0.5 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0197 | 0.3389 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0301 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0301 | 0.0887 |
Echinococcus multilocularis | Protein lozenge | 0.006 | 0.0139 | 0.0409 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0387 | 0.7898 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0066 | 0.0301 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0287 | 0.5523 | 0.6348 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0217 | 0.3872 | 0.375 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0301 | 0.0887 |
Loa Loa (eye worm) | NHE-3 | 0.0066 | 0.0301 | 0.0164 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0151 | 0.2297 | 0.1387 |
Onchocerca volvulus | 0.0197 | 0.3389 | 0.3185 | |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0387 | 0.7898 | 1 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 0.5 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0301 | 0.0887 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 0.5 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0066 | 0.0301 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0301 | 0.0164 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0197 | 0.3389 | 0.3066 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0197 | 0.3389 | 0.3185 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0066 | 0.0301 | 0.0164 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0301 | 0.0887 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0066 | 0.0301 | 0.0887 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0197 | 0.3389 | 0.5 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0391 | 0.8 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0066 | 0.0301 | 0.0887 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0066 | 0.0301 | 0.0887 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0217 | 0.3872 | 0.3809 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0197 | 0.3389 | 1 |
Onchocerca volvulus | 0.0475 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0301 | 0.0164 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0066 | 0.0301 | 0.0164 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0197 | 0.3389 | 0.5 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0387 | 0.7898 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0301 | 0.0887 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0287 | 0.5523 | 0.6348 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0151 | 0.2297 | 0.1387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.7 uM | Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells | ChEMBL. | 15828827 |
IC50 (binding) | = 1.7 uM | Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells | ChEMBL. | 15828827 |
RPP (functional) | = 17 % | In vitro cardioprotective effect of the compound was determined in isolated ischemic rat heart model as recovery of rate pressure product (RPP) at 10 uM | ChEMBL. | 15828827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.