Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.0977 | 0.4501 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0045 | 0.0105 | 0.0105 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0219 | 0.247 | 0.247 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0404 | 0.4994 | 0.4994 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0056 | 0.0253 | 0.0253 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0384 | 0.4717 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0195 | 0.0176 |
Onchocerca volvulus | 0.0188 | 0.2053 | 0.3509 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1317 | 0.2189 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.0684 | 0.1206 |
Schistosoma mansoni | high-affinity choline transporter | 0.0404 | 0.4994 | 0.4994 |
Schistosoma mansoni | sodium/solute symporter | 0.0045 | 0.0105 | 0.0105 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0056 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0143 | 0.0083 |
Brugia malayi | mbt repeat family protein | 0.0056 | 0.0253 | 0.0445 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0195 | 0.0195 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0442 | 0.0442 |
Brugia malayi | GH02984p | 0.0404 | 0.4994 | 0.8804 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0045 | 0.0105 | 0.0041 |
Echinococcus multilocularis | solute carrier family 5 | 0.0045 | 0.0105 | 0.0105 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0195 | 0.0343 |
Schistosoma mansoni | uracil phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0212 | 0.2379 | 0.5004 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.038 | 0.4659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0105 | 0.0015 |
Brugia malayi | PAS domain containing protein | 0.0071 | 0.046 | 0.0811 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0104 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0173 | 0.0137 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0109 | 0.0977 | 0.1906 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0044 | 0.0097 | 0.0097 |
Echinococcus multilocularis | adenine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0045 | 0.0105 | 0.0105 |
Echinococcus granulosus | solute carrier family 5 | 0.0045 | 0.0105 | 0.0105 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0109 | 0.0977 | 0.193 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0253 | 0.0253 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0219 | 0.247 | 0.247 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0773 | 1 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0134 | 0.1317 | 0.2322 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0044 | 0.0097 | 0.017 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0056 | 0.0253 | 0.0253 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0195 | 0.0195 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Onchocerca volvulus | 0.0053 | 0.0218 | 0.0218 | |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.5672 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0153 | 0.1575 | 0.1575 |
Brugia malayi | hypothetical protein | 0.0454 | 0.5672 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0045 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | runx1 | 0.0057 | 0.0273 | 0.0316 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0281 | 0.3314 | 0.7053 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0056 | 0.0253 | 0.0253 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0144 | 0.1455 | 0.2977 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0195 | 0.0195 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0212 | 0.2379 | 0.4941 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0205 | 0.2286 | 0.2286 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | inositol transporter | 0.0045 | 0.0105 | 0.0105 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.038 | 0.4659 | 1 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0044 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0357 | 0.0467 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0063 | 0.0357 | 0.0357 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1325 | 0.2203 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0045 | 0.0105 | 0.0105 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Brugia malayi | Sodium:solute symporter family protein | 0.0045 | 0.0105 | 0.0184 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0144 | 0.1455 | 0.2977 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0195 | 0.0195 |
Echinococcus granulosus | adenine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Brugia malayi | bHLH-PAS transcription factor | 0.0052 | 0.021 | 0.037 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0773 | 1 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0044 | 0.0097 | 0.0097 |
Schistosoma mansoni | lozenge | 0.0057 | 0.0273 | 0.0273 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Brugia malayi | mbt repeat family protein | 0.0056 | 0.0253 | 0.0445 |
Onchocerca volvulus | 0.0454 | 0.5672 | 1 | |
Onchocerca volvulus | 0.0152 | 0.1567 | 0.2637 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4994 | 0.8784 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0056 | 0.0253 | 0.028 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0195 | 0.0195 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0045 | 0.0105 | 0.0014 | |
Leishmania major | xanthine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0045 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0056 | 0.0253 | 0.028 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0281 | 0.3314 | 0.7053 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0188 | 0.2053 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0109 | 0.0977 | 0.193 |
Echinococcus multilocularis | Protein lozenge | 0.0057 | 0.0273 | 0.0273 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0109 | 0.0977 | 0.193 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0253 | 0.028 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.0499 | 0.0499 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0056 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0105 | 0.0014 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0153 | 0.1575 | 0.1575 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0384 | 0.4717 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0063 | 0.0357 | 0.0629 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0195 | 0.0195 |
Onchocerca volvulus | 0.0056 | 0.0253 | 0.028 | |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0404 | 0.4994 | 0.4994 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1567 | 0.2637 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0045 | 0.0105 | 0.0105 |
Brugia malayi | Adenine phosphoribosyltransferase | 0.0044 | 0.0097 | 0.017 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0281 | 0.3314 | 0.7053 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0063 | 0.0357 | 0.0357 |
Echinococcus granulosus | single minded 2 | 0.0052 | 0.021 | 0.021 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0442 | 0.0442 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0384 | 0.4717 | 1 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | single-minded | 0.0071 | 0.046 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.5672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0617 | 0.0933 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0067 | 0.0067 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0045 | 0.0105 | 0.0105 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0052 | 0.021 | 0.021 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0063 | 0.0357 | 0.0357 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.038 | 0.4659 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0109 | 0.0977 | 0.193 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0063 | 0.0357 | 0.0357 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0109 | 0.0977 | 0.193 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0188 | 0.2053 | 0.4288 |
Loa Loa (eye worm) | MBCTL1 | 0.0063 | 0.0357 | 0.0467 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0188 | 0.2053 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0253 | 0.0253 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0188 | 0.2053 | 0.2053 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0063 | 0.0357 | 0.0357 |
Schistosoma mansoni | inositol transporter | 0.0045 | 0.0105 | 0.0105 |
Mycobacterium ulcerans | putative regulatory protein | 0.0052 | 0.021 | 0.0249 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0195 | 0.0195 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0188 | 0.2053 | 0.3619 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MEC (functional) | = 0.5 ug ml-1 | Minimum effective concentration required to induce interferon (IFN) production in human peripheral blood mononuclear cells (hPBMC) | ChEMBL. | 15887957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.